Why is this medication prescribed?

Beremagene geperpavec-svdt is used to treat certain adults and children 6 months of age or older who have dystrophic epidermolysis bullosa (an inherited disorder that causes the skin to be fragile leading to blisters, wounds, skin infections, and scarring). Beremagene geperpavec-svdt is in a class of medications called gene therapy. It works by replacing a gene that promotes wound healing by strengthening and stabilizing the skin.

How should this medicine be used?

Beremagene geperpavec-svdt is supplied as a gel that a medical practitioner can apply to their skin at home or at a clinic. Usually, it is given directly to wounds once every seven days. Up until the wound heals fully, treatment is administered.

Your doctor might not be able to treat every wound during a single visit. Depending on the severity of your wounds, your doctor will select which ones to treat and most likely develop a plan for treating them in order of priority. It’s critical to keep treating any wound(s) every week until they heal fully. Your doctor will most likely treat more wounds once the first one has fully healed.

Do not come into touch with bandages, dressings, or treated wounds for approximately 24 hours following beremagene geperpavec-svdt treatment. Bandages, dressings, and treated wounds should not be handled or scratched. Wash the afflicted area thoroughly with water if contact occurs.

How to change your wound dressings will be explained by your doctor to you or a caregiver. As you change a wound dressing, wash your hands and put on safety gloves. You will be instructed by your physician to discard discarded wound dressings and gloves. Pay close attention to these instructions. If you have any concerns about getting rid of wound dressings, speak with your physician or pharmacist.

Request a copy of the patient’s manufacturer’s information from your pharmacist or physician.

Other uses for this medicine

Ask your doctor or pharmacist for more information if you think this medicine could be recommended for something else.

What special precautions should I follow?

Regarding special precautions for Beremagene geperpavec-svdt, it’s important to follow the guidance provided by your healthcare provider closely. Here are some general precautions that may apply:

• If you have an allergy to any of the ingredients in beremagene geperpavec-svdt gel, any other medications, or beremagene geperpavec-svdt itself, let your doctor and pharmacist know. Get an ingredient list from your pharmacist.
• Inform your physician and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal remedies you now take or intend to use.
• Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Contact your physician if you become pregnant while taking beremagene geperpavec-svdt.

Always consult with your healthcare provider for personalized guidance and recommendations regarding the use of Beremagene geperpavec-svdt and any specific precautions that may apply to your individual circumstances.

What special dietary instructions should I follow?

There are typically no specific dietary instructions associated with its use. However, maintaining a balanced and healthy diet is generally beneficial for overall health and well-being.

What should I do if I forget a dose?

Since Beremagene geperpavec-svdt is not administered on a regular dosing schedule like traditional medications, there are no specific instructions regarding missed doses. However, if you have any concerns or questions about your treatment, including the timing or administration of Beremagene geperpavec-svdt, it’s essential to contact your healthcare provider for guidance.

What side effects can this medication cause?

Beremagene geperpavec-svdt, like any medical treatment, can potentially cause side effects. However, it’s important to note that the incidence and severity of side effects may vary from person to person. The most common side effects reported in clinical trials of Beremagene geperpavec-svdt include:

• Itching
• Rash
• Redness
• Chills
• Cough
• Runny nose

It’s important for patients to discuss any concerns about potential side effects with their healthcare provider before undergoing treatment with Beremagene geperpavec-svdt. Healthcare providers will closely monitor patients for any adverse reactions and provide appropriate management as needed.

As with any medical treatment, the potential benefits of Beremagene geperpavec-svdt should be weighed against the risks, and patients should be informed about the expected outcomes and possible side effects before making treatment decisions.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Beremagene geperpavec-svdt is typically stored and handled by healthcare professionals in a hospital or specialized facility.
• Proper storage conditions for the medication are maintained according to the manufacturer’s guidelines to ensure its stability and efficacy.
• Disposal of any unused portions or materials associated with the administration of Beremagene geperpavec-svdt is typically managed by healthcare facilities following established protocols for the disposal of biological materials and medical waste.

In case of emergency/overdose

• In the event of an emergency or suspected overdose related to Beremagene geperpavec-svdt, immediate medical attention should be sought.
• Healthcare providers are trained to manage emergencies and adverse reactions associated with medical procedures and treatments, including gene therapy.
• Patients should contact their healthcare provider or seek emergency medical assistance if they experience any unexpected or severe symptoms following treatment with Beremagene geperpavec-svdt.

What other information should I know?

• Patients and caregivers should receive thorough education and counseling from healthcare providers regarding the purpose, administration procedure, potential benefits, and risks associated with Beremagene geperpavec-svdt.
• Regular follow-up appointments with healthcare providers are important for monitoring treatment response, assessing any side effects or complications, and addressing any questions or concerns.
• Genetic counseling may be recommended for patients and their families to provide information and support regarding the underlying genetic condition and the implications of treatment.
• Patients should inform their healthcare providers about any medications, or medical conditions they have before undergoing treatment with Beremagene geperpavec-svdt to ensure safe and appropriate care.

As always, patients should follow the guidance and instructions provided by their healthcare providers regarding the use of Beremagene geperpavec-svdt and any specific considerations that apply to their individual circumstances.