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Benzylpenicillin Procaine (Generic Penicillin G Procaine Injection)

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Why is this medication prescribed?

Injections of penicillin G and procaine are used to treat some bacterial infections. Gonorrhea, a sexually transmitted disease, and the first stages of some dangerous infections shouldn’t be treated with penicillin G procaine injection. The pharmaceutical penicillin G procaine injection belongs to the penicillin drug class. It functions by eradicating the infection-causing germs.

Colds, the flu, or other viral diseases cannot be treated with antibiotics like penicillin G procaine injection. Antibiotic use that is not necessary raises the likelihood of developing a later infection that is resistant to antibiotic treatment.

How should this medicine be used?

In a medical setting, a doctor or nurse will use a prefilled syringe to provide penicillin G procaine injection as a suspension (liquid) into the buttocks or thigh muscles. It is typically administered once daily. The sort of illness you have and how well you respond to the medication will determine how long your treatment will last.

During the first several days of treatment with penicillin G procaine injection, you should start to feel better. Call your doctor if your symptoms don’t go away or get worse.

Even if you feel better, make sure to keep all appointments for penicillin G procaine injection on time. Your illness could not be entirely treated if you stop getting penicillin G procaine injections too soon or skip doses, and the bacteria might develop an antibiotic resistance.

After obtaining a dosage of penicillin G procaine injection, you can have a quick, acute reaction that lasts for 15 to 30 minutes. In the moments following your injection, be sure to let your doctor know if you have any of the following signs and symptoms: agitation, disorientation, depression, weakness, seizures, hearing voices or seeing things that aren’t there, violent behaviour, or dread of death.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving penicillin G procaine injection,

  • Inform your doctor and pharmacist if you have any allergies to penicillin G procaine injection, cephalosporin antibiotics like cefaclor, cefadroxil, cefazolin (Ancef, Kefzol), cefepime, cefixime, cefotaxime, cefoxitin, cefpodoxime, cefprozil, ceftazidime (Fortaz, Tazicef), ceftibuten ( If you are unsure whether a drug you are allergic to falls under one of these categories, see your doctor or pharmacist. If you have a reaction to any of the components in penicillin G procaine injection, let your doctor know right once. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention tetracycline and probenecid (Probalan) (Achromycin). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have or have ever had asthma, allergies, hay fever, hives, or renal disease, let your doctor know.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you conceive while having an injection of penicillin G procaine.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Call your doctor as soon as you can if you fail to show up for a penicillin G procaine injection visit.

What side effects can this medication cause?

Injections of procaine with penicillin G could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Bruising, bleeding, lumps, or other symptoms in the vicinity of the injection site for the medicine

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Rash
  • Hives
  • Itching
  • Breathing or swallowing challenges
  • Swelling of the lower legs, hands, feet, ankles, or face, neck, tongue, lips, eyes, or mouth
  • Hoarseness
  • Unwell throat
  • Chills
  • Fever
  • Headache
  • Joint or muscle ache
  • Weakness
  • Rapid heart rate
  • After your therapy, you may experience severe diarrhoea (watery or bloody stools) with fever and/or stomach cramps for up to 2 months or longer
  • Quick development of tingling, numbness, and muscle weakness in the lower back
  • Skin darkening in the drug injection site that is blue or black
  • Blistering, peeling, or shedding of the skin in the region of the injection site
  • Numbness in the arms or legs at the injection site of the medicine

Other negative effects from penicillin G procaine injection could occur. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Twitching
  • Seizures

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the injection of penicillin G procaine, your doctor will request a number of lab tests.

Ask your pharmacist any inquiries you may have regarding the injection of penicillin G procaine.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Duracillin A-S ®
  • Pfizerpen A-S®
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