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Benzathine Benzylpenicillin (Generic Penicillin G Benzathine Injection)

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Never administer penicillin G benzathine injection intravenously (into a vein), as this could result in significant or fatal side effects.

Why is this medication prescribed?

Injections of penicillin G benzathine are used to treat and prevent several bacterial infections. The antibiotic known as penicillins include penicillin G benzathine injection. It functions by eradicating the infection-causing germs.

Colds, the flu, and other viral diseases cannot be treated with antibiotics like penicillin G benzathine injection. Antibiotic use that is not necessary raises the likelihood of developing a later infection that is resistant to antibiotic treatment.

How should this medicine be used?

In a medical setting, a doctor or nurse will administer penicillin G benzathine injection as a suspension (liquid) into the buttocks or thigh muscles. A single dosage of penicillin G benzathine injection may be administered. Additional doses may be administered with at least a 7-day gap between them when used to treat or prevent specific dangerous infections. If you have any concerns regarding how many doses you will require or when you will receive them, speak with your doctor.

During the first several days of treatment with penicillin G benzathine injection, you should start to feel better. Call your doctor if your symptoms don’t go away or get worse.

If your doctor has told you that you will need additional doses of penicillin G benzathine injection, make sure to keep all appointments to receive your doses on schedule even if you are feeling better. If you stop using penicillin G benzathine injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving penicillin G benzathine injection,

  • If you have an allergy to cephalosporin antibiotics like cefaclor, cefadroxil, cefzolin (Ancef, Kefzol), cefditoren (Spectracef), cefpime (Maxipime), or cefixime, let your doctor and pharmacist know right away (Suprax), ceftibuten (Cedax), ceftriaxone (Rocephin), cefotaxime (Claforan), cefoxitin (Cefoxitin), cefpodoxime (Cefpodoxime), cefprozil (Cefprozil), ceftazidime (Fortaz, Tazicef), cefuroxime (Ceftin, Zinacef), and cephalexin  (Keflex); or any other medications. If you’re unsure whether a medicine to which you have an allergy falls under one of these categories, consult your doctor or pharmacist. If you have a reaction to any of the components of penicillin G benzathine injection, let your doctor know right once. For a list of the ingredients, ask your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention tetracycline and probenecid (Probalan) (Achromycin). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have or have ever had asthma, allergies, hay fever, hives, or renal disease, let your doctor know.
  • If you are breastfeeding a child or intend to become pregnant, let your doctor know. Call your doctor if you conceive while having penicillin G benzathine injection.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Call your doctor as soon as you can if you are going to be late for an injection of penicillin G benzathine.

What side effects can this medication cause?

Injections of penicillin G benzathine may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Bruising, bleeding, lumps, or other symptoms in the vicinity of the injection site for the medicine

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Rash
  • Hives
  • Itching
  • Breathing or swallowing challenges
  • Swelling of the lower legs, hands, feet, ankles, or face, neck, tongue, lips, eyes, or mouth
  • Hoarseness
  • Unwell throat
  • Chills
  • Fever
  • Headache
  • Joint or muscle ache
  • Weakness
  • Rapid heart rate
  • After your therapy, you may experience severe diarrhoea (watery or bloody stools) with fever and/or stomach cramps for up to 2 months or longer
  • Quick development of tingling, numbness, and muscle weakness in the lower back
  • Skin darkening in the drug injection site that is blue or black
  • Blistering, peeling, or shedding of the skin in the region of the injection site
  • Numbness in the leg or arm where the injection site was

Other negative effects from penicillin G benzathine injection are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Twitching
  • Seizures

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor how your body is responding to an injection of penicillin G benzathine, your doctor may request specific lab tests.

Any queries you may have regarding the injection of penicillin G should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Bicillin L-A®
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