WARNING

Baricitinib is a medication used to treat rheumatoid arthritis and other autoimmune conditions. Like many medications, it comes with potential risks. Some of the common risks associated with taking Baricitinib include:

• Increased Risk of Infections: Baricitinib can suppress the immune system, making it harder for the body to fight off infections. This can increase the risk of developing bacterial, viral, or fungal infections.
• Serious Allergic Reactions: Some people may experience severe allergic reactions to Baricitinib, which can cause symptoms such as difficulty breathing, swelling of the face or throat, and rash.
• Liver Problems: Baricitinib can affect liver function and may lead to liver damage or abnormal liver test results. Regular monitoring of liver function is usually recommended while taking this medication.
• Blood Clotting: There may be an increased risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism, in people taking Baricitinib.
• Elevated Cholesterol Levels: Baricitinib may cause an increase in cholesterol levels, which could raise the risk of cardiovascular problems such as heart attacks or strokes.
• Gastrointestinal Perforations: In rare cases, Baricitinib has been associated with gastrointestinal perforations, which are serious and potentially life-threatening conditions where a hole forms in the stomach or intestines.

It’s important for individuals considering or taking Baricitinib to discuss these risks with their healthcare provider and to be closely monitored for any signs of adverse effects while on the medication.

Why is this medication prescribed?

Baricitinib is prescribed primarily to treat rheumatoid arthritis (RA), a chronic autoimmune disorder that causes inflammation in the joints, leading to pain, stiffness, and swelling. It is also used in the treatment of other autoimmune conditions like psoriatic arthritis and moderate to severe atopic dermatitis in certain cases.

Baricitinib works by inhibiting Janus kinase (JAK) enzymes, which play a role in the immune system’s inflammatory response. By blocking these enzymes, Baricitinib helps reduce inflammation and alleviate symptoms associated with autoimmune diseases.

How should this medicine be used?

Baricitinib is typically taken orally in tablet form. Here’s a general guideline on how it should be used:

• Dosage: The recommended dosage of Baricitinib depends on the specific condition being treated and individual factors such as age, weight, and medical history. The usual starting dose for adults with rheumatoid arthritis is 4 mg once daily. However, your healthcare provider may adjust the dosage based on your response to treatment and any side effects experienced.
• Administration: Baricitinib tablets should be taken by mouth, with or without food. Swallow the tablet whole with water; do not crush, split, or chew it.
• Timing: It’s typically recommended to take Baricitinib at the same time each day to maintain consistent levels of the medication in your body.
• Monitoring: Regular check-ups and monitoring are essential while taking Baricitinib. Your healthcare provider may periodically assess your condition, perform blood tests, and monitor for any potential side effects or complications.
• Follow Healthcare Provider’s Instructions: Always follow your healthcare provider’s instructions regarding the use of Baricitinib. Do not adjust the dosage or stop taking the medication without consulting your healthcare provider, as doing so may affect its effectiveness or lead to adverse effects.
• Adverse Effects: Be aware of potential side effects of Baricitinib, such as increased risk of infections, allergic reactions, liver problems, blood clotting, elevated cholesterol levels, and gastrointestinal perforations. If you experience any concerning symptoms while taking Baricitinib, contact your healthcare provider promptly.

It’s crucial to have open communication with your healthcare provider about your treatment with Baricitinib, including any concerns or questions you may have. They can provide personalized guidance based on your individual needs and medical history.

Other uses for this medicine

In addition to rheumatoid arthritis, baricitinib may also be prescribed for other autoimmune conditions such as psoriatic arthritis and moderate to severe atopic dermatitis in certain cases. Its use in these conditions is based on clinical judgment and individual patient factors, and it’s important to follow your healthcare provider’s guidance regarding its use for any specific condition.

What special precautions should I follow?

When taking baricitinib, it’s essential to follow some special precautions:

• Regular Monitoring: Your healthcare provider may recommend regular check-ups and monitoring while taking baricitinib to assess its effectiveness and watch for any potential side effects or complications. This may include blood tests to monitor for changes in liver function, cholesterol levels, and other parameters.
• Infections: Baricitinib can increase the risk of infections due to its immunosuppressive effects. It’s important to be vigilant for signs of infection and to promptly report any symptoms such as fever, chills, cough, sore throat, or unusual fatigue to your healthcare provider.
• Vaccinations: Before starting baricitinib treatment, discuss your vaccination history with your healthcare provider. Some vaccinations may be recommended before initiating therapy with baricitinib, as live vaccines are generally not recommended while taking this medication. Your healthcare provider can advise you on the appropriate timing for vaccinations.
• Allergic Reactions: If you have a known allergy to baricitinib or any of its components, inform your healthcare provider before starting treatment. Watch for signs of allergic reactions, such as difficulty breathing, swelling of the face or throat, rash, or itching, and seek medical attention immediately if these symptoms occur.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of baricitinib treatment with your healthcare provider. The safety of baricitinib during pregnancy and breastfeeding is not well established, and your healthcare provider can help you make an informed decision regarding its use in your specific situation.
• Other Medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with baricitinib. Certain medications, such as strong CYP3A4 inhibitors or inducers, may affect the metabolism of baricitinib and require dosage adjustments or monitoring.

By following these precautions and communicating openly with your healthcare provider, you can maximize the benefits of baricitinib treatment while minimizing the risk of potential adverse effects.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with taking Baricitinib. However, maintaining a balanced and healthy diet can support overall health and well-being.

What should I do if I forget a dose?

• Take it as soon as you remember: If you miss a dose of Baricitinib, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not double up: Do not take a double dose to make up for a missed one. Taking more than the prescribed dose of Baricitinib can increase the risk of side effects and complications.
• Notify your healthcare provider: If you frequently forget doses or have difficulty adhering to your medication schedule, notify your healthcare provider. They may provide guidance or strategies to help you remember to take your medication consistently.

What side effects can this medication cause?

Baricitinib, like any medication, can cause side effects. Common side effects may include:

• Upper respiratory tract infections: Such as the common cold or sinus infections.
• Nausea: Feeling sick to your stomach.
• Headache: Pain in the head.
• Herpes zoster infection: Also known as shingles, a viral infection causing painful rashes.
• Elevated liver enzymes: Detected through blood tests.
• Hypertension: High blood pressure.
• Increased cholesterol levels: Elevated levels of fats in the blood.
• Nasopharyngitis: Inflammation of the nose and throat.
• Anemia: A decrease in red blood cells.
• Increased risk of blood clots: Including deep vein thrombosis (DVT) and pulmonary embolism.

Less common but more serious side effects can occur, including:

• Serious infections: Due to the suppression of the immune system, leading to potentially severe bacterial, viral, or fungal infections.
• Allergic reactions: Such as difficulty breathing, swelling of the face or throat, rash, or itching.
• Liver problems: Including abnormal liver function and liver damage.
• Gastrointestinal perforations: Rare but serious conditions where a hole forms in the stomach or intestines.
• Thrombosis: Formation of blood clots in blood vessels.
• Lymphoma and other malignancies: Although rare, there may be an increased risk of certain cancers.

It’s important to be aware of these potential side effects and to promptly report any unusual symptoms or reactions to your healthcare provider. They can provide guidance on managing side effects and may adjust your treatment regimen if necessary.

What should I know about storage and disposal of this medication?

Here’s what you should know about the storage and disposal of Baricitinib:

• Storage: Store Baricitinib tablets at room temperature between 68°F to 77°F (20°C to 25°C). Keep the medication in its original container, tightly closed, and away from moisture and heat. Avoid storing it in the bathroom or kitchen where humidity can affect its stability.
• Disposal: Dispose of Baricitinib tablets properly according to local regulations or guidelines. Do not flush them down the toilet or pour them down the drain unless instructed to do so. Instead, consult your healthcare provider, pharmacist, or local waste disposal facility for instructions on safe disposal methods.

In case of emergency/overdose

• Seek medical attention: If you suspect an overdose or experience severe symptoms after taking Baricitinib, such as difficulty breathing, severe allergic reactions, or signs of liver problems, seek immediate medical attention or contact your local poison control center.
• Provide information: If possible, provide healthcare providers with information about the medication you have taken, including the name of the medication (Baricitinib), the dosage strength, and the amount ingested.

What other information should I know?

• Regular monitoring: Your healthcare provider may recommend regular monitoring while taking Baricitinib to assess its effectiveness and monitor for any potential side effects or complications. This may include periodic blood tests and check-ups.
• Follow-up appointments: Attend all scheduled follow-up appointments with your healthcare provider to evaluate your response to treatment and make any necessary adjustments to your medication regimen.
• Medication interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Baricitinib. Certain medications, such as strong CYP3A4 inhibitors or inducers, may affect the metabolism of Baricitinib and require dosage adjustments or monitoring.
• Patient support: Consider joining support groups or seeking counseling if you have concerns or questions about your condition or treatment with Baricitinib. Talking to others who are going through similar experiences can provide valuable support and information.

By following these guidelines and staying informed about your medication, you can help ensure the safe and effective use of Baricitinib in managing your condition.