WARNING

Bamlanivimab and Etesevimab injection, used together to treat COVID-19, do carry some risks. Common side effects include nausea, dizziness, headache, and allergic reactions like rash or itching. More severe reactions, though rare, may include infusion-related reactions, which can range from mild to serious and may include difficulty breathing or low blood pressure. Additionally, there’s a risk of developing resistant variants of the virus after treatment. It’s crucial for patients to discuss potential risks with their healthcare provider before undergoing treatment with these medications.

Why is this medication prescribed?

Bamlanivimab and etesevimab injection are prescribed for the treatment of mild to moderate cases of COVID-19 in individuals who are at high risk of progressing to severe disease or hospitalization. These medications are monoclonal antibodies that work by attaching to the spike protein of the SARS-CoV-2 virus, thereby preventing it from entering human cells and replicating.

High-risk individuals who may benefit from this treatment include those who are elderly, immunocompromised, or have certain underlying medical conditions such as obesity, diabetes, or cardiovascular disease. This therapy is typically administered early in the course of the illness, ideally within the first few days of symptom onset, to reduce the risk of disease progression.

How should this medicine be used?

Bamlanivimab and Etesevimab Injection should be administered intravenously by a healthcare professional in a clinical setting. The typical dosage for adults and adolescents weighing 40 kg (88 pounds) or more is 2,400 mg (1,200 mg of bamlanivimab and 1,200 mg of etesevimab) administered together as a single infusion over a period of approximately 60 minutes.

It’s crucial to follow the healthcare provider’s instructions precisely regarding the timing and administration of the injection. The injection should ideally be given as soon as possible after a positive COVID-19 test result and within a specific timeframe from the onset of symptoms.

Patients should be monitored during and after the infusion for any potential adverse reactions. If an infusion reaction occurs, appropriate medical treatment should be administered promptly.

As with any medication, it’s important for patients to discuss potential risks and benefits with their healthcare provider before receiving Bamlanivimab and Etesevimab Injection. Additionally, patients should follow any other recommendations provided by their healthcare provider regarding COVID-19 management and precautions.

Other uses for this medicine

Bamlanivimab and Etesevimab Injection are primarily used for the treatment of COVID-19 in certain high-risk individuals who have tested positive for the virus and are at risk of developing severe symptoms. Currently, there are no other approved uses for this medication beyond its intended purpose in treating COVID-19.

What special precautions should I follow?

When receiving Bamlanivimab and Etesevimab Injection, it’s essential to follow certain precautions to ensure safety and effectiveness:

• Inform your healthcare provider: Disclose any allergies, medical conditions, or medications you are currently taking before receiving the injection. This information will help your healthcare provider assess any potential risks or interactions.
• Monitor for allergic reactions: Pay close attention to any signs of allergic reactions, such as rash, itching, swelling, or difficulty breathing, during and after the infusion. Inform your healthcare provider immediately if you experience any of these symptoms.
• Stay hydrated: Ensure adequate hydration before and after receiving the injection, as this can help minimize the risk of infusion-related reactions.
• Follow healthcare provider instructions: Adhere to the recommended timing and dosage of the injection as prescribed by your healthcare provider. Attend all scheduled appointments for monitoring and follow-up.

As always, patients should consult their healthcare provider for personalized guidance and advice regarding the use of Bamlanivimab and Etesevimab Injection and any specific precautions that may apply to their individual situation.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are no specific dietary restrictions associated with Bamlanivimab and Etesevimab Injection. However, maintaining a healthy and balanced diet can support overall health and immune function, which may aid in recovery from COVID-19.

What should I do if I forget a dose?

If you forget a dose of Bamlanivimab and Etesevimab Injection, contact your healthcare provider or clinic as soon as possible to reschedule the missed dose. It’s essential to complete the full course of treatment as prescribed for optimal effectiveness in managing COVID-19. Avoid doubling up on doses without consulting your healthcare provider first. They can provide guidance on the best course of action based on your individual circumstances.

What side effects can this medication cause?

Bamlanivimab and Etesevimab Injection, like any medication, can cause side effects. Common side effects reported with this medication include:

• Infusion-related reactions: These reactions can range from mild to severe and may include symptoms such as fever, chills, nausea, headache, dizziness, fatigue, shortness of breath, or low blood pressure.
• Allergic reactions: Some individuals may experience allergic reactions to Bamlanivimab and Etesevimab Injection, which can manifest as rash, itching, swelling (especially of the face, lips, tongue, or throat), or difficulty breathing.
• Nausea and vomiting: These gastrointestinal symptoms are relatively common with Bamlanivimab and Etesevimab Injection.
• Headache: Headaches are another reported side effect, though they are typically mild to moderate in severity.
• Fatigue: Some individuals may experience fatigue or weakness after receiving the injection.
• Dizziness: Dizziness or lightheadedness may occur in some patients.
• Rash or itching: Skin reactions, such as rash or itching, have been reported in some cases.

It’s important to note that not all individuals will experience these side effects, and some may experience side effects not listed here. Additionally, severe side effects are rare but possible. If you experience any concerning or persistent side effects after receiving Bamlanivimab and Etesevimab Injection, it’s essential to inform your healthcare provider promptly. They can provide guidance on managing side effects and determine if any further medical attention is necessary.

What should I know about storage and disposal of this medication?

Storage and disposal:

• Storage: Bamlanivimab and Etesevimab Injection should be stored by the healthcare provider in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F) in the original carton to protect it from light. Do not freeze. The medication should be used before the expiration date printed on the carton and vial label.
• Disposal: Unused portions of the medication or empty vials should be disposed of according to local regulations for hazardous waste disposal. It’s essential to follow proper disposal procedures to prevent accidental exposure or environmental contamination.

In case of emergency/overdose

In case of emergency or overdose, seek immediate medical attention by contacting your local emergency services or going to the nearest emergency room. Provide healthcare providers with as much information as possible about the medication taken, including the name and dosage of Bamlanivimab and Etesevimab Injection.

What other information should I know?

Before receiving Bamlanivimab and Etesevimab Injection, inform your healthcare provider about any allergies, medical conditions, or medications you are currently taking. Follow all instructions provided by your healthcare provider regarding the timing, dosage, and administration of the injection. Attend all scheduled appointments for monitoring and follow-up.

Additionally, continue to practice recommended preventive measures to reduce the risk of COVID-19 transmission, such as wearing masks, practicing good hand hygiene, maintaining physical distance from others, and following public health guidelines.

If you have any questions or concerns about Bamlanivimab and Etesevimab Injection or its use, don’t hesitate to discuss them with your healthcare provider. They can provide personalized guidance and address any concerns you may have.