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Why is this medication prescribed?

Avatrombopag is prescribed to people with chronic (ongoing) liver disease who are scheduled to undergo a medical or dental procedure in order to treat thrombocytopenia (a low number of platelets [type of blood cell needed for blood clotting]). This is done in order to help prevent complications related to bleeding. Additionally, it is used to treat thrombocytopenia in patients with persistent immune thrombocytopenia (ITP; a disorder that may result in unusual bleeding or bruising due to an unusually low amount of platelets in the blood) who did not respond to another form of treatment. Thrombopoietin (TPO) receptor agonists are a group of drugs that includes avatrombopag. It functions by increasing the body’s platelet production.

How should this medicine be used?

A tablet to be swallowed with food contains avatrombopag. It is typically taken once day with food for five days, beginning 10 to 13 days before the surgery, for the treatment of thrombocytopenia in persons with chronic liver disease who are scheduled to undergo a procedure. It is typically given once day with food for the duration of the prescribed period to treat thrombocytopenia in ITP patients. Avatrombopag should be taken every day at roughly the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Avatrombopag should be taken as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Your doctor will likely start you on a modest dose of avatrombopag for the treatment of thrombocytopenia in persons with ITP and may change your dose based on how you respond to the drug.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking avatrombopag,

  • If you have any allergies, including to avatrombopag, other medications, or any of the substances in avatrombopag tablets, notify your doctor right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Make careful to mention any of the following: rifampin or fluconazole (Rifadin, Rimactane, in Rifamate, in Rifater). Avatrombopag may also interact with numerous other drugs, so be sure to inform your doctor of all the drugs you are taking, even those not on this list. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have a hereditary disease that increases your risk of blood clots or if you have ever had a blood clot, let your doctor know.
  • If you are pregnant or plan to become pregnant, inform your doctor right away. Call your doctor right away if you get pregnant while taking avatrombopag.
  • Describe to your doctor if you are nursing a baby. Breastfeeding is likely to be prohibited throughout treatment and for two weeks following your last dosage, according to your doctor.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Take the missing dose as soon as you remember it if you are taking avatrombopag to treat thrombocytopenia right before a surgery. Skip the missed dose if it is almost time for the next one and carry on with your regular dosing schedule, but make sure you take the entire prescribed amount of medication (even if they are not taken 5 days in a row). To make up for a missing dose, do not take a second one.

Take the missing dose of avatrombopag as soon as you remember if you are treating chronic immune thrombocytopenia with it. Skip the missed dose if it is almost time for the next one and carry on with your regular dosing regimen. To make up for a missing dose, don’t take a second one.

What side effects can this medication cause?

There can be negative effects from avatrombopag. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Extreme fatigue
  • Headache
  • Bleeding gums or the nose
  • Joints hurt

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or symptoms:

  • Leg that is swollen, aching, red, or tender
  • Chest pain, fever, coughing, shortness of breath, or a rapid heartbeat
  • Stomach ache or discomfort
  • Swelling of the feet or hands

There may be more adverse effects from avatrombopag. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication out of the reach of children and properly closed in its original container. Store it at room temperature, away from extreme heat and moisture (not in the bathroom).

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Swelling, uncomfortable, sensitive, or red leg
  • Chest pain, a cough, shortness of breath, and a rapid heartbeat
  • Stomach ache or discomfort

What other information should I know?

Keep all of your appointments with your physician and the lab. In order to determine your avatrombopag dose and the day of the procedure, your doctor will run a number of lab tests before you begin therapy.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Doptelet®
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