Why is this medication prescribed?

Augtyro (Generic Repotrectinib) is a medication prescribed for the treatment of certain types of cancer. Specifically, it’s used to target and treat non-small cell lung cancer (NSCLC) and other tumors that have specific genetic mutations or alterations, such as ROS1 or NTRK gene fusions. Augtyro works as a tyrosine kinase inhibitor, targeting and blocking abnormal proteins that contribute to cancer cell growth and spread.

How should this medicine be used?

Here are some general guidelines for its use:

• Administration: Augtyro is usually taken orally in the form of tablets. The dosage and schedule depend on the specific condition being treated and how the patient responds to the medication.
• Dosage: Follow the exact dosage prescribed by your healthcare provider. It’s important to take Augtyro at the same time each day to maintain consistent levels in your body.
• With or Without Food: Augtyro can be taken with or without food. However, it’s generally recommended to take it consistently with respect to meals to avoid variations in absorption.
• Monitoring: Regular monitoring by your healthcare provider is important to assess the effectiveness of the treatment and to check for any potential side effects.
• Missed Dose: If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not double up to make up for a missed dose.
• Interactions: Inform your healthcare provider about all other medications, supplements, and health conditions, as there could be interactions with Augtyro.

Always follow your healthcare provider’s instructions and consult them if you have any questions or concerns about using Augtyro.

Other uses for this medicine

Augtyro (repotrectinib) is primarily prescribed for treating cancers with specific genetic alterations, particularly non-small cell lung cancer (NSCLC) with ROS1 or NTRK gene fusions. Its use in these contexts is based on its ability to target and inhibit the activity of proteins produced by these genetic mutations.

What special precautions should I follow?

Special Precautions:

• Allergic Reactions: Inform your healthcare provider if you have a history of allergies to any medications. Severe allergic reactions to Augtyro are rare but possible.
• Liver Function: Augtyro can affect liver function. Your doctor will monitor liver enzyme levels regularly and adjust the dose if necessary. Inform your healthcare provider if you have any history of liver disease.
• Heart Problems: Augtyro may affect heart function, so inform your healthcare provider if you have a history of heart disease or experience symptoms such as shortness of breath, chest pain, or swelling in your legs or ankles.
• Drug Interactions: Some medications can interact with Augtyro, affecting its effectiveness or increasing the risk of side effects. Provide a complete list of all medications and supplements you are taking to your healthcare provider.
• Pregnancy and Breastfeeding: Augtyro may harm an unborn baby. Use effective contraception while taking this medication and inform your healthcare provider if you are pregnant, plan to become pregnant, or are breastfeeding.
• Regular Monitoring: Regular medical check-ups and blood tests are essential to monitor for side effects and assess the effectiveness of the treatment.
• Side Effects: Be aware of potential side effects such as fatigue, nausea, diarrhea, or any new symptoms. Report any severe or persistent side effects to your healthcare provider immediately.
• Avoid Grapefruit: Grapefruit and grapefruit juice can interact with many medications, including Augtyro, potentially increasing side effects. Avoid consuming grapefruit products unless advised otherwise by your healthcare provider.

Always follow the instructions provided by your healthcare provider and discuss any concerns or questions about Augtyro and its use.

What special dietary instructions should I follow?

• Food Interaction: Augtyro can be taken with or without food, but it’s best to take it consistently in the same manner (either always with food or always without) to avoid variations in drug absorption.
• Grapefruit: Avoid grapefruit and grapefruit juice, as they can interact with Augtyro and potentially increase the risk of side effects.

What should I do if I forget a dose?

• Timing: If you miss a dose of Augtyro, take it as soon as you remember unless it’s almost time for your next scheduled dose. In this case, skip the missed dose and resume your regular dosing schedule.
• Do Not Double Up: Do not take two doses at the same time to make up for a missed dose.
• Contact Healthcare Provider: If you’re unsure about what to do after missing a dose, contact your healthcare provider for guidance.

What side effects can this medication cause?

Augtyro (repotrectinib) may cause a range of side effects. Some of the most common and serious side effects include:

Common Side Effects:

• Fatigue: Feeling unusually tired or weak.
• Nausea: Feeling queasy or having an upset stomach.
• Diarrhea: Frequent, loose, or watery stools.
• Headache: Pain or discomfort in the head.
• Muscle or Joint Pain: Aching or discomfort in muscles or joints.
• Decreased Appetite: Reduced interest in eating.

Serious Side Effects:

• Liver Problems: Symptoms might include jaundice (yellowing of the skin or eyes), dark urine, severe nausea, or abdominal pain.
• Heart Issues: Symptoms such as chest pain, irregular heartbeat, shortness of breath, or swelling in the legs and ankles.
• Severe Allergic Reactions: Rash, itching, swelling, severe dizziness, or trouble breathing.
• Respiratory Issues: Difficulty breathing or a persistent cough.
• Rash: Skin changes or eruptions.
• Vomiting: Throwing up or severe nausea.

Inform your healthcare provider if you experience any of these side effects, especially if they are severe or persistent. Seek immediate medical attention if you experience symptoms of severe allergic reactions or other serious side effects.

Monitoring and managing side effects are important for ensuring the effectiveness of the treatment and maintaining your overall well-being. Always discuss any concerns or unusual symptoms with your healthcare provider.

What should I know about storage and disposal of this medication?

Storage and Disposal of Augtyro:

Storage:

• Store Augtyro at room temperature, away from moisture and heat. Typically, this means keeping it in a dry place at temperatures between 68°F to 77°F (20°C to 25°C).
• Keep the medication in its original container with the lid tightly closed to protect it from light and moisture.

Disposal:

• Dispose of Augtyro according to the guidelines provided by your pharmacist or healthcare provider. They can offer specific instructions based on local regulations.
• Consider using a medication take-back program or a drug disposal kiosk if available in your area. This helps ensure the medication is disposed of safely.
• If no take-back programs are available, you might be able to dispose of Augtyro in your household trash, but make sure to mix it with an undesirable substance (like used coffee grounds or cat litter) and place it in a sealed plastic bag to prevent accidental ingestion.

In case of emergency/overdose

• Contact Poison Control: Immediately contact your local poison control center or emergency services if you suspect an overdose.
• Symptoms of Overdose: Symptoms of an overdose may include severe fatigue, nausea, vomiting, or other severe reactions. Seek emergency medical attention if you experience these symptoms.
• Provide Information: Be ready to provide information about the medication (Augtyro) and the amount taken to healthcare professionals.

What other information should I know?

• Regular Monitoring: Regular follow-up appointments with your healthcare provider are important for monitoring your response to the medication and checking for side effects.
• Lab Tests: You may need periodic lab tests to monitor liver function, heart health, and other aspects of your health while on Augtyro.
• Drug Interactions: Keep your healthcare provider informed about all other medications and supplements you are taking to avoid potential interactions.
• Lifestyle Changes: Follow any lifestyle or dietary recommendations provided by your healthcare provider to support the effectiveness of Augtyro and overall health.

Always adhere to the guidance given by your healthcare provider and consult them if you have any questions or concerns about Augtyro or its use.