Why is this medication prescribed?

Atelvia (Generic Risedronate) is a prescription medication that belongs to a class of drugs called bisphosphonates. Atelvia is used to treat osteoporosis in postmenopausal women. Osteoporosis is a condition in which bones become thin and weak, making them more prone to fractures. The medication helps increase bone mass and reduce the chance of having a spinal or hip fracture. It may also be prescribed to prevent osteoporosis in women who are at risk of developing the condition. Atelvia may be used to treat Paget’s disease, a chronic condition that can result in enlarged and deformed bones.

How should this medicine be used?

Atelvia (generic name: risedronate) is a bisphosphonate used to treat or prevent osteoporosis in postmenopausal women and to increase bone mass in men with osteoporosis. Here’s how to use it:

• Dosage: The usual dose is one 35 mg tablet once a week. Follow your doctor’s instructions on the exact dosage.
• Administration:
  • Take Atelvia first thing in the morning after you wake up.
  • Take it with a full glass of water (about 6 to 8 ounces).
  • Do not take it with any other beverages or food.
  • Swallow the tablet whole. Do not chew or crush it.
• Post-Dosing Instructions: After taking Atelvia, do not lie down for at least 30 minutes. This helps prevent irritation of the esophagus. Avoid eating or drinking anything other than water for at least 30 minutes after taking the medication.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose; do not double up.
• Storage: Store Atelvia at room temperature, away from moisture and heat.
• Precautions: Inform your doctor if you have any issues with your esophagus, kidney problems, or low blood calcium levels. Make sure to maintain adequate calcium and vitamin D intake.

Always follow your healthcare provider’s specific instructions and consult them if you have any questions or concerns about using Atelvia.

Other uses for this medicine

Atelvia is primarily prescribed for the treatment and prevention of osteoporosis and Paget’s disease of bone. However, it may sometimes be used off-label for other conditions where bone loss or weakening is a concern, such as:

• Glucocorticoid-Induced Osteoporosis: This is osteoporosis caused by long-term use of corticosteroids (e.g., prednisone), which can weaken bones.
• Osteogenesis Imperfecta: A rare genetic disorder characterized by brittle bones. Atelvia may be considered to improve bone density.

What special precautions should I follow?

Special Precautions to Follow When Using Atelvia:

• Allergies: Inform your doctor if you have any allergies to risedronate or other bisphosphonates, or any inactive ingredients in the tablet.
• Medical History: Disclose any history of esophageal problems (such as narrowing or difficulty swallowing), low calcium levels (hypocalcemia), stomach/intestinal disorders, or severe kidney disease.
• Calcium and Vitamin D Levels: Ensure you have adequate levels of calcium and vitamin D before starting Atelvia. Your doctor may prescribe supplements if needed, as low levels can reduce the drug’s effectiveness and may increase side effects.
• Dental Health: Inform your dentist that you are taking Atelvia before any dental procedures. Atelvia has been associated with a rare but serious condition called osteonecrosis of the jaw (ONJ). Regular dental check-ups and maintaining good oral hygiene are recommended.
• Swallowing Difficulties: Do not take Atelvia if you have difficulty swallowing or if you cannot stay upright for at least 30 minutes, as it can cause severe esophageal irritation or ulcers.
• Pregnancy and Breastfeeding: Atelvia is not recommended during pregnancy or breastfeeding. Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
• Interactions: Avoid taking antacids, calcium supplements, or other medications that contain aluminum, magnesium, or iron within 30 minutes of Atelvia, as these can interfere with its absorption. Inform your healthcare provider about all other medications, including over-the-counter drugs and supplements, to avoid potential interactions.
• Hydration: Drink plenty of water while taking Atelvia to prevent dehydration and reduce the risk of kidney problems.

Always follow your healthcare provider’s guidance and report any unusual symptoms or side effects promptly.

What special dietary instructions should I follow?

• Take After Breakfast: Atelvia should be taken immediately after breakfast. This is unlike many other bisphosphonates, which are usually taken on an empty stomach.
• Adequate Calcium and Vitamin D Intake: Ensure you consume enough calcium and vitamin D in your diet or through supplements, as directed by your doctor. These nutrients are essential for bone health and the effectiveness of Atelvia.
• Avoid Certain Foods and Drinks: Do not take Atelvia with mineral water, coffee, tea, juice, or any beverage other than plain water. Avoid eating foods high in calcium (such as dairy products) or taking antacids, calcium supplements, or iron within 30 minutes of taking Atelvia, as these can interfere with its absorption.

What should I do if I forget a dose?

• If you miss a dose of Atelvia, take it the next morning after you remember. Then, continue with your regular weekly schedule.
• Do Not take two tablets on the same day to make up for the missed dose.
• If you remember the missed dose on the day of your next scheduled dose, skip the missed dose and take the next dose as usual.

What side effects can this medication cause?

Atelvia (risedronate) can cause side effects, though not everyone will experience them. Common and less common side effects include:

Common Side Effects:

• Digestive Issues: Such as nausea, abdominal pain, constipation, or diarrhea.
• Musculoskeletal Pain: Such as bone, joint, or muscle pain.

Less Common Side Effects:

• Esophageal Irritation: Including esophagitis, ulcers, or pain when swallowing.
• Flu-like Symptoms: Such as fever, chills, and muscle aches.
• Severe Bone, Joint, or Muscle Pain: Rare but can occur.
• Jaw Problems: Osteonecrosis of the jaw, especially after dental procedures.
• Unusual Thigh Bone Fractures: Rare but can occur with long-term use.
• Kidney Problems: Rarely, issues like changes in kidney function tests.
• Severe Allergic Reactions: Such as rash, itching, swelling, severe dizziness, or trouble breathing.
• Severe Esophageal Problems: Including difficulty swallowing, severe chest pain, or persistent heartburn.

If you experience severe side effects or any symptoms that concern you, contact your healthcare provider immediately. They can provide guidance and determine if the medication needs to be adjusted or discontinued.

What should I know about storage and disposal of this medication?

Storage and Disposal of Atelvia:

Storage:

• Store Atelvia at room temperature, between 68°F and 77°F (20°C to 25°C).
• Keep it in a dry place, away from moisture and humidity.
• Store the medication in its original container, tightly closed to protect it from moisture and light.
• Keep Atelvia out of the reach of children and pets.

Disposal:

• Dispose of Atelvia according to your local pharmacy or waste disposal guidelines. Many communities have take-back programs for medications.
• Check if your area has a medication take-back program or disposal site.
•  If no take-back programs are available, you may dispose of Atelvia in the household trash. Mix the medication with an undesirable substance (e.g., used coffee grounds or kitty litter) in a sealed bag or container to prevent leakage.
• Throw the mixture in your household trash. Do not flush Atelvia down the toilet or sink unless the label or patient information specifically instructs you to do so.

In case of emergency/overdose

• Symptoms of Overdose: Overdose symptoms may include severe stomach pain, nausea, vomiting, or heartburn. Severe cases might result in esophageal irritation or ulcers.
• Immediate Actions: If you suspect an overdose, call your local poison control center at 1-800-222-1222 (in the U.S.) or seek emergency medical help immediately.
• Provide Information: Be prepared to provide information such as the name of the medication, the amount taken, and the time of ingestion.

What other information should I know?

• Regular Check-ups: Schedule regular follow-ups with your healthcare provider to monitor bone health and any potential side effects of Atelvia.
• Report Side Effects: Inform your healthcare provider of any new or worsening symptoms. This helps in managing and adjusting treatment if needed.
• Medication Interactions: Discuss all other medications, supplements, and health conditions with your healthcare provider to avoid interactions.
• Compliance: Follow the prescribed dosing schedule strictly to ensure effectiveness and reduce the risk of side effects.
• Patient Information Leaflet: Read the patient information leaflet provided with Atelvia for specific instructions and additional information.

Always follow your healthcare provider’s instructions and consult them if you have any questions or concerns about your medication.