Why is this medication prescribed?

Asparlas is prescribed to treat acute lymphoblastic leukemia (ALL), a type of cancer that affects the white blood cells. It is specifically used as part of a multi-drug chemotherapy regimen for patients who are newly diagnosed with ALL. The medication works by depleting the levels of asparagine, an amino acid that certain leukemia cells require to survive, thereby inhibiting their growth.

How should this medicine be used?

Asparlas (Generic Calaspargase Pegol-mknl Injection) is administered by a healthcare professional. Here’s how it is typically used:

• Administration: Asparlas is given as an intravenous (IV) infusion by a healthcare professional, usually in a hospital or clinic setting.
• Dosage: The dosage and schedule depend on the patient’s body surface area, age, and the specific chemotherapy regimen being used. It is typically administered every 3 weeks as part of a planned chemotherapy cycle.
• Duration: The treatment plan, including how often and how long Asparlas is given, will be determined by the healthcare provider based on the individual patient’s condition and response to therapy.
• Monitoring: Patients receiving Asparlas will undergo regular monitoring, including blood tests and liver function tests, to check for side effects and to ensure the medication is working effectively.

Always follow your healthcare provider’s instructions regarding the use of this medication and report any unusual symptoms or side effects.

Other uses for this medicine

Currently, Asparlas (Calaspargase Pegol-mknl Injection) is primarily approved for the treatment of acute lymphoblastic leukemia (ALL) in combination with other chemotherapy agents. It is not commonly prescribed for other uses. However, research may explore its potential use in other types of cancers or conditions where reducing the amino acid asparagine could have therapeutic benefits.

What special precautions should I follow?

Special Precautions to Follow for Asparlas:

• Allergic Reactions: Inform your doctor if you have a history of allergic reactions to Asparlas, pegylated asparaginase, L-asparaginase, or any other medications. Serious allergic reactions (such as anaphylaxis) may occur.
• Medical History: Inform your doctor about your entire medical history, especially if you have:
  • Pancreatitis (inflammation of the pancreas)
  • Liver disease or liver problems
  • Blood clotting disorders or history of blood clots
  • Diabetes or high blood sugar levels
• Blood Monitoring: Regular blood tests are required to monitor blood cell counts, liver function, and coagulation status, as Asparlas can affect these parameters.
• Pancreatitis Risk: Be aware of the symptoms of pancreatitis (severe stomach pain, nausea, vomiting), as Asparlas can increase the risk of developing this condition. Seek immediate medical attention if these symptoms occur.
• Blood Sugar Levels: Asparlas may cause hyperglycemia (high blood sugar). Monitor blood sugar levels if you have diabetes or are at risk of developing diabetes.
• Avoid Vaccinations: Do not receive any live vaccines (such as measles, mumps, or rubella) while using Asparlas and for some time after treatment, as it can weaken your immune system.
• Pregnancy and Breastfeeding: Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Asparlas can harm an unborn baby, and breastfeeding is not recommended during treatment.
• Surgery or Dental Procedures: Inform your healthcare provider that you are using Asparlas before any surgery or dental procedure, as it can affect blood clotting.

Always adhere to the guidance provided by your healthcare team and contact them if you have any concerns or experience any adverse effects.

What special dietary instructions should I follow?

• General Healthy Diet: While no specific dietary restrictions are necessary, maintaining a healthy, balanced diet rich in fruits, vegetables, whole grains, and lean proteins is advisable to support overall health.
• Monitor Blood Sugar: Since Asparlas may affect blood sugar levels, monitor your intake of carbohydrates and sugars, especially if you are diabetic or at risk for diabetes.
• Avoid Alcohol: Limit or avoid alcohol consumption, as it can increase the risk of liver damage and interfere with your medication’s effectiveness.

What should I do if I forget a dose?

If you miss a dose of Asparlas, contact your healthcare provider immediately. Asparlas is administered in a clinical setting, and the healthcare team will provide instructions or reschedule the dose based on your treatment plan. Do not try to make up for a missed dose by yourself.

What side effects can this medication cause?

Asparlas (Calaspargase Pegol-mknl Injection) can cause various side effects, ranging from mild to severe. It’s essential to be aware of these potential side effects and report any concerning symptoms to your healthcare provider.

Common Side Effects of Asparlas:

• Allergic Reactions: Symptoms may include rash, itching, hives, swelling (especially of the face, tongue, or throat), and difficulty breathing. Severe allergic reactions (anaphylaxis) can occur.
• Gastrointestinal Issues:
  • Nausea and vomiting
  • Abdominal pain
  • Diarrhea
• Fatigue: Feeling unusually tired or weak is a common side effect.
• Fever: Elevated body temperature, which may indicate an infection or other immune response.
• Loss of Appetite: Reduced desire to eat, which may lead to weight loss over time.

Serious Side Effects of Asparlas:

• Pancreatitis: Inflammation of the pancreas, which can cause severe abdominal pain, nausea, and vomiting. This condition may require immediate medical attention.
• Liver Toxicity: Symptoms may include jaundice (yellowing of the skin or eyes), dark urine, severe fatigue, and upper right abdominal pain. Liver function tests are typically monitored regularly.
• Blood Clotting Disorders: Increased risk of blood clots (thrombosis), which may present as pain, redness, swelling, or warmth in a limb or sudden chest pain and shortness of breath. Bleeding issues, such as unusual bruising, prolonged bleeding, or blood in stools or urine.
• Hyperglycemia (High Blood Sugar): Symptoms may include increased thirst, frequent urination, blurred vision, and unexplained weight loss.
• Central Nervous System Effects: Possible symptoms include confusion, severe headaches, dizziness, vision changes, and seizures.
• Decreased Blood Cell Counts:
  • Low white blood cell count (leukopenia or neutropenia) can increase the risk of infection.
  • Low platelet count (thrombocytopenia) can increase the risk of bleeding.
• Hypersensitivity Reactions: Severe skin reactions, including redness, blistering, peeling, or swelling.
• Edema: Swelling, particularly in the hands, feet, or legs.
• Kidney Problems: Changes in urination, swelling, and unusual tiredness.
• Immune System Suppression: Increased susceptibility to infections.

Seek immediate medical attention if you experience severe or unusual symptoms, such as difficulty breathing, severe abdominal pain, signs of liver issues, confusion, or signs of a blood clot.

What should I know about storage and disposal of this medication?

Storage and Disposal of Asparlas:

• Storage:
  • Asparlas is usually stored and prepared by healthcare professionals in a hospital or clinic setting. It is kept in a refrigerator (2°C to 8°C or 36°F to 46°F) and must be protected from light.
  • Freezing Asparlas can damage the medication, so it should not be stored in a freezer.
  • If the medication needs to be stored at home, follow the storage instructions provided by the healthcare provider or pharmacist. Keep it in its original container, out of reach of children and pets.
• Disposal:
  • Asparlas is generally disposed of by healthcare professionals following specific medical waste guidelines. Do not attempt to dispose of this medication at home.
  • Return any unused or expired Asparlas to a pharmacy or disposal program according to local regulations.

In case of emergency/overdose

• Overdose Symptoms: Although unlikely since Asparlas is administered by healthcare professionals, symptoms of overdose may include severe allergic reactions, pancreatitis, liver toxicity, abnormal bleeding or clotting, and neurological symptoms.
• Seek Immediate Medical Attention: If an overdose is suspected, contact emergency medical services immediately.
• Hospital Emergency Room: Go to the nearest hospital emergency room for evaluation and treatment.
• Poison Control Center: Contact your local poison control center for additional guidance.

What other information should I know?

• Regular Monitoring: You will need frequent blood tests to monitor your liver function, blood cell counts, and other health parameters while receiving Asparlas.
• Inform Healthcare Providers: Always inform any healthcare provider (including dentists) that you are receiving Asparlas before undergoing any medical or dental procedures, as it can affect blood clotting and other bodily functions.
• Reporting Side Effects: Report any side effects to your healthcare provider, especially severe or unusual symptoms, to adjust your treatment plan if necessary.
• Medication Interactions: Keep a list of all medications you are taking, including prescription drugs, over-the-counter medications, and supplements. Share this list with your healthcare provider to avoid potential interactions.
• Avoid Live Vaccines: Do not receive live vaccines while using Asparlas, as it can weaken the immune system and increase the risk of infections.

Always follow the specific instructions given by your healthcare provider and consult them with any concerns or questions about your treatment and care.