WARNING

Asenapine transdermal patches are used to treat schizophrenia and bipolar disorder. Here are some potential risks and side effects associated with their use:

• Drowsiness and Sedation: The patch can cause significant drowsiness or sedation, which may affect daily activities.
• Weight Gain: Weight gain is a common side effect, which could lead to metabolic issues.
• Movement Disorders: Some people may experience extrapyramidal symptoms like tremors, stiffness, or involuntary movements.
• Cardiovascular Issues: The medication might cause changes in blood pressure or heart rate, which should be monitored.
• Allergic Reactions: There is a risk of allergic reactions at the site of the patch or systemic reactions.
• Gastrointestinal Issues: Nausea, vomiting, or constipation can occur.
• Mental Status Changes: Changes in mood or mental status, including increased risk of suicidal thoughts, may happen.
• Interactions: Asenapine can interact with other medications, so it’s important to inform your healthcare provider about all other drugs you’re taking.

Always follow your healthcare provider’s instructions and report any unusual or severe side effects promptly.

Why is this medication prescribed?

Asenapine transdermal patches are prescribed primarily for the treatment of schizophrenia and bipolar disorder. The medication, which is an atypical antipsychotic, works by affecting certain neurotransmitters in the brain, such as serotonin and dopamine. The transdermal patch allows the medication to be absorbed through the skin and into the bloodstream, providing a steady release of the drug over time.

How should this medicine be used?

How to Use Asenapine Transdermal Patch:

• Application: Apply the patch to a clean, dry, and intact area of skin on your back, abdomen, thigh, or upper arm. Avoid areas with cuts, irritation, or excessive hair. Stick the patch to your skin and press down for a few seconds to ensure it sticks well.
• Frequency: Patches are usually applied once a week. Follow your healthcare provider’s instructions regarding how often to change the patch.
• Rotation: Rotate the application sites to reduce skin irritation. Don’t apply a new patch to the same spot until it’s been at least a week since you last used that area.
• Removing the Patch: Remove the old patch before applying a new one. If the patch is difficult to remove, you can use mild soap and water.
• Handling: Wash your hands before and after handling the patch. Avoid touching the sticky side of the patch.
• Disposal: Dispose of used patches properly, as directed by your healthcare provider or the product’s instructions.

Always follow the specific instructions provided by your healthcare provider or the manufacturer for the best results and to minimize the risk of side effects.

Other uses for this medicine

The primary uses for asenapine transdermal patches are for managing schizophrenia and bipolar disorder. Off-label uses are not well-documented or recommended due to the potential risks and the need for more research.

What special precautions should I follow?

Special Precautions for Asenapine Transdermal Patch:

• Allergies: Inform your healthcare provider if you have any known allergies to asenapine or any other medications, as well as any adhesive sensitivities.
• Medical History: Share your complete medical history with your healthcare provider, including any history of heart disease, liver problems, or psychiatric disorders.
• Interactions: Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins, to avoid potential drug interactions.
• Pregnancy and Breastfeeding: If you are pregnant, plan to become pregnant, or are breastfeeding, discuss the risks and benefits of using asenapine with your healthcare provider.
• Skin Conditions: Avoid applying the patch to areas with skin conditions or irritations.
• Cardiovascular Monitoring: Regularly monitor blood pressure and heart rate as asenapine can cause changes in these parameters.
• Mental Health Monitoring: Monitor for any changes in mood, behavior, or mental status, as the medication can potentially worsen symptoms or induce new psychiatric symptoms.
• Avoid Alcohol: Limit or avoid alcohol consumption, as it can increase the risk of drowsiness and other side effects.
• Driving and Operating Machinery: Be cautious when performing tasks that require mental alertness or coordination, such as driving, especially when starting the medication or adjusting the dose.

Always adhere to your healthcare provider’s guidance and report any concerning side effects or changes in your condition.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with asenapine transdermal patches. However, maintaining a balanced diet and avoiding excessive alcohol can help manage side effects like weight gain and drowsiness.

What should I do if I forget a dose?

• Apply a new patch as soon as you remember. Ensure that you do not apply two patches at once to make up for the missed dose.
• If it’s almost time for your next scheduled patch change, skip the missed patch and resume your regular schedule.
• Apply more than one patch at a time to compensate for a missed dose. This can increase the risk of side effects.

What side effects can this medication cause?

Asenapine transdermal patches can cause a range of side effects, some of which may require medical attention. Here are common and serious side effects:

Common Side Effects:

• Drowsiness or Sedation: Feeling unusually sleepy or tired.
• Weight Gain: Increased body weight over time.
• Dry Mouth: A persistent dry feeling in the mouth.
• Headache: General head pain or discomfort.
• Skin Reactions: Redness, itching, or irritation at the application site.
• Nausea: Feeling sick to your stomach or upset stomach.

Serious Side Effects:

• Extrapyramidal Symptoms: Symptoms such as tremors, rigidity, or involuntary movements.
• Cardiovascular Issues: Changes in blood pressure, rapid or irregular heartbeat.
• Severe Allergic Reactions: Symptoms like rash, itching, swelling, severe dizziness, or trouble breathing.
• Mental Status Changes: New or worsening symptoms of mental health conditions, such as suicidal thoughts or significant mood changes.
• Severe Skin Reactions: Significant irritation, blistering, or severe reactions at the patch site.
• Neuroleptic Malignant Syndrome (NMS): A rare but serious condition characterized by muscle rigidity, high fever, and autonomic instability. Seek immediate medical attention if you experience these symptoms.
• Hyperglycemia: Elevated blood sugar levels, which can be significant in individuals with diabetes or those at risk of diabetes.

If you experience any severe or unusual symptoms, contact your healthcare provider promptly. Regular follow-ups can help manage and mitigate side effects effectively.

What should I know about storage and disposal of this medication?

Storage and Disposal of Asenapine Transdermal Patch:

• Storage:
  • Store the patches at room temperature, away from direct heat, light, and moisture. Typically, this means between 68°F and 77°F (20°C and 25°C).
  • Do not store the patches in the refrigerator or freezer.
  • Store the patches in a safe place where children cannot access them.
• Disposal:
  • Fold the used patch in half with the sticky sides together and dispose of it in the household trash. Do not flush it down the toilet or throw it directly in the trash without folding.
  • Follow local regulations or guidelines for the disposal of medications. Some areas have drug take-back programs or specific disposal instructions.

In case of emergency/overdose

• Signs of Overdose:
  • Severe drowsiness or sedation.
  • Difficulty breathing or severe dizziness.
  • Unusual muscle movements or tremors.
  • Confusion or severe mood changes.
• Immediate Actions:
  • Contact Emergency Services: If you suspect an overdose, seek immediate medical attention or call emergency services.
  • Call Poison Control: Contact your local poison control center for advice and assistance.
  • Do Not Self-Treat: Avoid trying to treat an overdose at home. Seek professional medical help immediately.

What other information should I know?

• Regular Monitoring: Regular follow-ups with your healthcare provider are important to monitor the effectiveness of the medication and to manage any side effects.
• Medical History: Keep your healthcare provider informed about any changes in your medical history or current health conditions.
• Drug Interactions: Always inform your healthcare provider about any other medications or supplements you are taking to avoid potential interactions.
• Adherence: Use the medication exactly as prescribed. Do not adjust the dose or stop using the patch without consulting your healthcare provider.
• Emergency Contact: Have the contact information for your healthcare provider or emergency services readily available in case of urgent issues.

By following these guidelines, you can help ensure the safe and effective use of asenapine transdermal patches. If you have any specific questions or concerns, consult your healthcare provider for personalized advice.