Why is this medication prescribed?

Asciminib is prescribed for the treatment of chronic myeloid leukemia (CML), specifically in cases where the disease is resistant or intolerant to other treatments. It is a type of tyrosine kinase inhibitor (TKI) that works by targeting and inhibiting the BCR-ABL1 protein, which is involved in the growth and proliferation of cancer cells in CML.

Asciminib is typically used in patients who have previously been treated with other TKIs but have not responded well or have developed resistance to those therapies. It offers a different mechanism of action compared to other TKIs, potentially providing an effective treatment option for those with difficult-to-treat CML.

How should this medicine be used?

Here’s how Asciminib is typically used:

• Dosage: The usual starting dose is 200 mg taken orally twice daily. However, the exact dosage and frequency may vary based on your specific condition and how you respond to the medication. Your healthcare provider will adjust your dose as needed.
• Administration: Take Asciminib with or without food, at the same times each day. Swallow the tablets whole with a glass of water. Do not crush or chew the tablets.
• Consistency: It’s important to take Asciminib exactly as prescribed by your healthcare provider. Do not skip doses or stop taking it without consulting your doctor, even if you feel better.
• Missed Dose: If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. In that case, skip the missed dose; do not double up to make up for a missed dose.
• Interactions: Inform your doctor about all other medications you’re taking, as some drugs can interact with Asciminib.

If you have any specific concerns or questions about your treatment, it’s always best to discuss them with your healthcare provider.

Other uses for this medicine

Asciminib is primarily indicated for chronic myeloid leukemia (CML) with resistance or intolerance to prior therapies. Currently, its use is mostly confined to this condition, with research ongoing into other potential applications.

What special precautions should I follow?

Special Precautions for Asciminib:

• Monitoring: Regular blood tests are required to monitor your blood counts and liver function while on Asciminib. Your doctor will use these tests to ensure the medication is working effectively and to check for side effects.
• Drug Interactions: Asciminib can interact with other medications, including some over-the-counter drugs and herbal supplements. Inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.
• Liver Function: Asciminib can affect liver function. Report any signs of liver issues, such as jaundice (yellowing of the skin or eyes), dark urine, or persistent nausea.
• Pregnancy and Breastfeeding: Asciminib should be used with caution during pregnancy and breastfeeding. It’s important to discuss potential risks with your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
• Side Effects: Be aware of potential side effects, including but not limited to low blood cell counts, fatigue, nausea, and rash. Contact your doctor if you experience severe or persistent side effects.
• Heart Conditions: Asciminib may affect heart function. If you have a history of heart disease or experience symptoms such as chest pain or shortness of breath, inform your healthcare provider.
• Adherence: It’s crucial to take Asciminib exactly as prescribed. Do not skip doses or stop the medication without consulting your healthcare provider, as this could impact the effectiveness of the treatment.

Always consult with your healthcare provider for personalized advice and guidance based on your specific health situation.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Asciminib. However, maintaining a balanced diet and staying hydrated can support overall health and well-being. Always consult your healthcare provider for any personalized dietary recommendations related to your treatment.

What should I do if I forget a dose?

• Take it as Soon as Possible: If you remember a missed dose within a few hours of the scheduled time, take it as soon as you can.
• Skip the Dose if It’s Almost Time for the Next One: If it’s nearly time for your next dose, skip the missed dose. Do not double up on doses to make up for a missed one.
• Consult Your Healthcare Provider: If you’re unsure about what to do or if you miss multiple doses, contact your healthcare provider for guidance.

What side effects can this medication cause?

Asciminib can cause a range of side effects. Some common and serious side effects include:

Common Side Effects:

• Fatigue: Feeling unusually tired or weak.
• Nausea: Feeling sick to your stomach or vomiting.
• Rash: Skin irritation or rash.
• Headache: Persistent or severe headaches.
• Diarrhea: Frequent, loose bowel movements.

Serious Side Effects:

• Low Blood Cell Counts: This can lead to anemia (low red blood cells), increased risk of infection (low white blood cells), or bleeding problems (low platelets).
• Liver Problems: Symptoms may include jaundice (yellowing of the skin or eyes), dark urine, or persistent nausea and vomiting.
• Heart Issues: Symptoms such as chest pain, shortness of breath, or swelling in the legs and ankles.
• Infection: Increased susceptibility to infections due to lowered white blood cell counts.
• Allergic Reactions: Severe allergic reactions can include rash, itching, swelling, dizziness, or trouble breathing.
• Severe Skin Reactions: This may include severe rash or peeling skin.

If you experience any severe or concerning symptoms, contact your healthcare provider immediately. They can provide guidance on managing side effects and whether any adjustments to your treatment are needed.

What should I know about storage and disposal of this medication?

Storage and Disposal of Asciminib:

• Storage:
  • Store Asciminib at room temperature, typically between 68°F to 77°F (20°C to 25°C).
  • Keep the medication in its original container, tightly closed, and away from moisture and heat.
  • Keep it out of reach of children and pets.
• Disposal:
  • Do not flush Asciminib down the toilet or pour it into a drain unless instructed to do so.
  • Dispose of unused or expired medication at a drug take-back program or a pharmacy that offers disposal services.
  • If no take-back programs are available, mix the medication with an undesirable substance (like used coffee grounds or cat litter), place it in a sealed bag, and discard it with your household trash.

In case of emergency/overdose

• Symptoms of Overdose: Symptoms may include severe nausea, vomiting, diarrhea, or other unusual effects.
• Contact Poison Control: Call your local poison control center or emergency services immediately for guidance.
• Seek Medical Attention: Go to the nearest emergency room or contact your healthcare provider right away.

What other information should I know?

• Regular Monitoring: Regular check-ups and blood tests are necessary to monitor the effectiveness of the medication and detect any side effects early.
• Adherence to Prescription: Take Asciminib exactly as prescribed. Do not alter the dose or frequency without consulting your healthcare provider.
• Consult Healthcare Providers: Inform all your healthcare providers about your use of Asciminib, including any new symptoms or health changes.

Always follow the specific instructions provided by your healthcare provider and refer to the medication guide that comes with Asciminib for detailed information.