Why is this medication prescribed?

Anifrolumab-fnia Injection is prescribed primarily for the treatment of moderate to severe systemic lupus erythematosus (SLE), a chronic autoimmune disease. It is used specifically in adults who are receiving standard therapy but require additional treatment to manage their condition. Anifrolumab works by targeting a specific protein, the type I interferon receptor, which plays a key role in the inflammatory process associated with lupus. By blocking this receptor, Anifrolumab helps reduce inflammation and modulate the immune system’s activity.

How should this medicine be used?

Here’s a general guide on how it is typically used:

• Administration: Anifrolumab-fnia is administered as an intravenous (IV) infusion by a healthcare provider. It is typically given over a period of 30 minutes.
• Dosage: The usual dosage is 300 mg every 4 weeks. The exact dosage and duration of treatment will depend on the patient’s condition and response to therapy.
• Location: The infusion is usually administered in a healthcare setting, such as a hospital or clinic, to allow for monitoring in case of any adverse reactions.
• Premedication: In some cases, premedication may be given to reduce the risk of infusion-related reactions.

Always follow your healthcare provider’s specific instructions for use and consult them if you have any questions or concerns about how to take Anifrolumab-fnia Injection.

Other uses for this medicine

Anifrolumab-fnia Injection is primarily approved for the treatment of systemic lupus erythematosus (SLE) in adults. While its primary use is for SLE, it is sometimes studied for other potential uses, such as in other autoimmune or inflammatory conditions. However, these uses are not yet established or FDA-approved and should only be considered in the context of clinical trials or under specific medical guidance.

What special precautions should I follow?

Special Precautions for Anifrolumab-fnia Injection:

• Allergies: Inform your healthcare provider if you have any known allergies to Anifrolumab or any other medications, including any components of the injection.
• Infection Risk: Anifrolumab may increase the risk of infections. Notify your doctor if you have any current or recurring infections or if you experience symptoms of infection (fever, chills, cough, sore throat, pain during urination, etc.) during treatment.
• Tuberculosis (TB) Screening: You may need to be tested for tuberculosis before starting treatment, as Anifrolumab can potentially activate latent TB.
• Vaccinations: Avoid live vaccines during and after treatment with Anifrolumab. You should complete any necessary vaccinations before starting therapy. Discuss with your doctor about any vaccines you may need.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The effects of Anifrolumab on an unborn baby or a breastfeeding infant are not fully known, so the medication should be used with caution.
• Medical History: Share your complete medical history, especially if you have any other autoimmune conditions, liver problems, or a weakened immune system.
• Drug Interactions: Discuss all medications you are taking, including prescription, over-the-counter, vitamins, and herbal supplements, as they may interact with Anifrolumab.
• Monitoring: Regular follow-up visits and blood tests may be required to monitor for side effects and to ensure the medication is working effectively.
• Photosensitivity: Anifrolumab may increase your sensitivity to sunlight. Protect yourself from the sun by wearing protective clothing and using sunscreen.
• Potential Allergic Reactions: Be aware of the signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, and seek immediate medical attention if they occur.

Always follow the specific guidance provided by your healthcare provider and consult them with any concerns or questions about Anifrolumab-fnia Injection. Regular monitoring and communication with your provider are essential for safe and effective use.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Anifrolumab-fnia Injection. However, maintaining a balanced diet is important to support overall health, especially when managing a condition like lupus. It’s best to discuss your diet with your healthcare provider to ensure that it complements your treatment plan.

What should I do if I forget a dose?

If you miss a dose of Anifrolumab-fnia, contact your healthcare provider as soon as possible. They will provide guidance on when to reschedule your missed infusion. Do not attempt to self-administer the medication or double up on doses.

What side effects can this medication cause?

Anifrolumab-fnia Injection, like any medication, may cause side effects. It’s important to be aware of them and consult your healthcare provider if you experience any.

Common Side Effects: Some side effects are relatively common and may not require medical attention unless they persist or worsen:

• Respiratory Tract Infections: Symptoms may include sore throat, cough, nasal congestion, and difficulty breathing.
• Headache: Mild to moderate headaches may occur during treatment.
• Nausea: You might feel nauseated, but this is usually temporary.
• Fatigue: Feeling unusually tired or weak is common, especially after infusions.
• Injection Site Reactions: Reactions such as redness, pain, or swelling at the injection site.
• Shingles (Herpes Zoster): Anifrolumab can increase the risk of reactivating the varicella-zoster virus, which causes shingles.

Serious Side Effects: Some side effects may be serious and require immediate medical attention:

• Severe Infections: Anifrolumab can increase the risk of serious infections (e.g., pneumonia, sepsis, tuberculosis). Symptoms include fever, chills, severe cough, shortness of breath, or pain during urination.
• Hypersensitivity or Allergic Reactions: Signs include rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, and difficulty breathing.
• Infusion-Related Reactions: Symptoms such as headache, nausea, chills, fever, and chest pain during or shortly after the infusion.
• Liver Problems: Signs include yellowing of the skin or eyes (jaundice), dark urine, or severe abdominal pain.
• Low Blood Cell Counts (Cytopenias): Symptoms include unusual bruising, bleeding, pale skin, and fatigue.
• Malignancies: There may be an increased risk of developing certain types of cancers with long-term use, though this is still being studied.
• Immune System Effects: Anifrolumab can impact your immune system, so your doctor may conduct regular blood tests to monitor for side effects or unusual changes in your health.

Contact your healthcare provider if you experience mild side effects that persist or become bothersome. Seek immediate medical attention if you experience any symptoms of severe infection, allergic reaction, or other serious side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal of Anifrolumab-fnia Injection:

• Storage:
  • Anifrolumab-fnia is typically stored and administered in a healthcare setting (hospital or clinic). It should be kept in the original packaging, protected from light, and stored in a refrigerator at 2°C to 8°C (36°F to 46°F).
  • Ensure that the injection is not frozen. Avoid shaking the vial, as it may affect the medication’s efficacy.
  • As with all medications, keep Anifrolumab-fnia out of the reach of children.
• Disposal:
  • Disposal of the medication, used needles, and syringes should be handled by healthcare professionals following local regulations for medical waste disposal.
  • If you have any unused or expired medication at home, consult your healthcare provider or local pharmacy for proper disposal instructions. Do not dispose of medications in household trash or flush them down the toilet unless instructed.

In case of emergency/overdose

• Symptoms of Overdose: An overdose of Anifrolumab-fnia is unlikely, as it is administered by a healthcare professional in a clinical setting. However, if you suspect an overdose, symptoms might include severe infusion-related reactions (e.g., severe headache, nausea, chills, fever, chest pain, difficulty breathing) or signs of a severe infection.
• Contact Emergency Services: Immediately call emergency services (911 in the U.S.) if you experience symptoms of an overdose or a severe allergic reaction.
• Go to the Nearest Hospital: Seek immediate medical attention at the nearest emergency room.

What other information should I know?

• Regular Monitoring: You may need regular blood tests to check for side effects, such as changes in liver function, blood cell counts, or signs of infection.
• Communicate with Your Healthcare Provider: Keep your healthcare provider informed about any new symptoms or health changes during treatment. Report any side effects, even if they seem minor.
• Inform Other Healthcare Providers: Always inform any healthcare professional you consult that you are receiving Anifrolumab-fnia, as it may affect other treatments or procedures.
• Lifestyle Adjustments: Avoid live vaccines and protect yourself from infections. Be mindful of photosensitivity and take precautions to protect your skin from the sun.
• Stay Informed: Make sure you understand how the medication works, its potential side effects, and any lifestyle changes or precautions you need to follow.

Always follow the specific instructions given by your healthcare provider and consult them with any questions or concerns regarding Anifrolumab-fnia Injection.