WARNING

Using testosterone topical carries several potential risks and side effects. It’s important to be aware of these to manage and mitigate them effectively. Here’s a detailed overview of the risks associated with testosterone topical:

• Irritation or Rash: Common skin side effects include redness, itching, or rash at the application site.
• Application Site Issues: Prolonged use may lead to skin reactions such as dryness, peeling, or discomfort.
• Increased Risk of Heart Disease: Testosterone therapy may increase the risk of heart attack, stroke, or other cardiovascular events, particularly in individuals with pre-existing heart conditions.
• Blood Clots: There is a potential risk for blood clots, which can lead to deep vein thrombosis (DVT) or pulmonary embolism.
• Prostate Enlargement: Testosterone can cause benign prostatic hyperplasia (BPH), leading to urinary difficulties.
• Prostate Cancer: There is a potential risk of exacerbating existing prostate cancer or stimulating its growth. Regular prostate exams may be required.
• Gynecomastia: An imbalance in testosterone levels can lead to breast tissue enlargement in men.
• Mood Swings: Testosterone therapy may cause mood swings, irritability, or aggressive behavior.
• Liver Dysfunction: Although rare with topical forms, there is a potential for liver dysfunction. Symptoms might include jaundice (yellowing of the skin or eyes), dark urine, or abdominal pain.
• Increased Red Blood Cell Count: Testosterone can lead to an increase in red blood cell count (erythrocytosis), which may increase the risk of blood clots and other complications.
• Changes in Cholesterol Levels: It may affect cholesterol levels, potentially increasing LDL (bad cholesterol) and decreasing HDL (good cholesterol).
• Reduced Sperm Production: Long-term use of testosterone can lead to decreased sperm production and potential infertility.
• Testicular Shrinkage: The natural production of testosterone in the testes may decrease, leading to testicular shrinkage.
• Sleep Apnea: Testosterone therapy can potentially worsen or trigger sleep apnea, a serious sleep disorder characterized by interrupted breathing during sleep.
• Mood Disorders: Some individuals may experience mood changes, including increased anxiety or depression.
• Misuse: There is a risk of misuse or abuse, particularly in individuals seeking performance enhancement or muscle building.

To minimize these risks, regular monitoring and consultations with your healthcare provider are essential. Your doctor may check hormone levels, liver function, cholesterol, and red blood cell counts.

If you experience any severe side effects or symptoms such as chest pain, difficulty breathing, severe skin reactions, or significant mood changes, contact your healthcare provider immediately.

Why is this medication prescribed?

Testosterone topical is prescribed primarily to treat low testosterone levels in men, a condition known as hypogonadism. This condition occurs when the body does not produce enough testosterone, a hormone that plays a key role in male development and health.

Uses of Testosterone Topical:

• Treatment of Hypogonadism: The most common use is to increase testosterone levels in adult men who have low or no testosterone due to certain medical conditions. Symptoms of low testosterone can include fatigue, mood changes, low libido, erectile dysfunction, reduced muscle mass, and bone density loss.
• Delayed Puberty in Males: It may be used in some cases to treat boys with delayed puberty to help trigger the onset of secondary sexual characteristics like deepening of the voice, growth of facial and body hair, and muscle development.
• Palliative Treatment of Breast Cancer in Women: Although less common, testosterone can be used as part of the treatment for certain types of breast cancer in postmenopausal women.

How should this medicine be used?

Testosterone topical gel and solution are used to treat low testosterone levels in men. Here are some general guidelines on how to use these forms of testosterone:

Testosterone Topical Gel:

• Application Site: Apply the gel to clean, dry skin on the upper arms, shoulders, or abdomen as directed by your doctor. Avoid applying it to the genitals.
• Dosage: Follow the specific dosage instructions provided by your healthcare provider. Typically, it’s applied once daily, usually in the morning.
• Application Steps: Wash your hands thoroughly before and after applying the gel. Apply the gel to the designated area. Spread it evenly and let it dry before dressing. Avoid washing or swimming in the area where the gel was applied for several hours to ensure absorption.
• Precautions: Keep the application site covered and avoid direct skin-to-skin contact with others in the application area. Ensure the application site is not exposed to sunlight or heat immediately after application. Wash the area with soap and water if you come into contact with others.

Testosterone Topical Solution:

• Application Site: Typically applied to the underarms (axillary) area. Follow your doctor’s specific instructions on application sites.
• Dosage: Usually applied once daily, generally in the morning. Use the provided applicator or spray as directed.
• Application Steps: Apply the solution directly to the clean, dry skin of the underarms. Follow the specific amount prescribed. Allow the solution to dry completely before dressing. Avoid washing or sweating in the application area for several hours.
• Precautions: Avoid skin-to-skin contact with others until the application area is dry. Wash your hands thoroughly after application. Avoid applying the solution to broken or irritated skin.

Regularly follow up with your healthcare provider to monitor your testosterone levels and adjust the dosage if needed. Report any side effects or unusual symptoms to your healthcare provider promptly. Always adhere to your healthcare provider’s instructions and the specific product guidelines for the best results and to minimize risks.

Other uses for this medicine

Testosterone Topical is primarily used for hormone replacement therapy in males with low testosterone levels. However, it can sometimes be used off-label for:

• Hormone Replacement Therapy for Transgender Men: To support the development of male secondary sexual characteristics.
• Treatment of Certain Conditions: Sometimes used in specific cases such as hypogonadism or other conditions where testosterone levels need to be managed.

What special precautions should I follow?

Special Precautions for Testosterone Topical:

• Medical History: Inform your doctor if you have a history of prostate or breast cancer, heart disease, high blood pressure, high cholesterol, liver or kidney disease, diabetes, or sleep apnea, as testosterone can worsen these conditions.
• Pregnancy and Breastfeeding: Avoid contact with women who are pregnant, breastfeeding, or trying to become pregnant. Testosterone can cause harmful effects to a fetus or an infant.
• Allergic Reactions: Inform your healthcare provider if you have any allergies, particularly to testosterone or any of the inactive ingredients in the gel or solution.
• Skin Reactions: Check for any redness, rash, or irritation at the application site. If irritation persists, consult your healthcare provider.
• Exposure to Others: Avoid skin contact with others, especially women and children, in the area where you applied testosterone. If contact occurs, the other person should wash the area with soap and water immediately.
• Heart and Liver Monitoring: Regularly monitor blood pressure, liver function, cholesterol levels, and hemoglobin/hematocrit levels, as testosterone can affect these parameters.
• Prostate Health: Regular prostate exams may be recommended, especially for older men, as testosterone therapy can increase the risk of prostate enlargement or cancer.
• Blood Clot Risk: Be aware that testosterone therapy may increase the risk of blood clots. Report any symptoms such as swelling, pain in the legs, shortness of breath, or chest pain to your healthcare provider.
• Avoiding Transfer: Make sure the gel or solution has dried completely and that the application site is covered with clothing to prevent accidental transfer to others.
• Limit Sun Exposure: Avoid direct sunlight or UV light on the application area until the gel or solution has dried, as exposure could alter the medication’s absorption.

Always follow your healthcare provider’s specific instructions and guidelines for safe and effective use.

What special dietary instructions should I follow?

• No Specific Dietary Restrictions: There are generally no specific dietary restrictions associated with testosterone topical. However, maintaining a balanced diet and healthy lifestyle can support overall treatment effectiveness.
• Consult Your Provider: If you have any dietary concerns or health conditions that might be affected by your diet, consult your healthcare provider for personalized advice.

What should I do if I forget a dose?

• Application Time: Apply the missed dose as soon as you remember, unless it’s almost time for your next scheduled dose.
• Avoid Double Dosing: Do not apply extra medication to make up for the missed dose.
• Resume Schedule: Continue with your regular dosing schedule.

What side effects can this medication cause?

Testosterone Topical can cause various side effects, some of which may be serious. Here’s a list of potential side effects:

Common Side Effects:

• Skin Irritation: Redness, itching, or rash at the application site.
• Acne: Breakouts on the skin.
• Increased Hair Growth: On the face or body.
• Headache: General discomfort in the head.
• Mood Changes: Irritability or mood swings.

Serious Side Effects:

• Chest Pain: Unusual pain or discomfort in the chest.
• Breathing Problems: Difficulty breathing or shortness of breath.
• Swelling: In the ankles, feet, or hands.
• Jaundice: Yellowing of the skin or eyes.
• Significant Mood Changes: Severe mood swings, aggression, or depression.
• Changes in Libido: Significant increase or decrease in sexual drive.
• Signs of Allergic Reaction: Rash, itching, swelling, severe dizziness, or trouble breathing.
• Heart Issues: Increased risk of cardiovascular problems, including heart attack or stroke.
• Prostate Issues: Potential for prostate enlargement or cancer.
• Liver Problems: Although less common with topical forms, liver function should be monitored.

If you experience any serious side effects or signs of an allergic reaction, seek medical attention immediately. Regular follow-ups with your healthcare provider can help monitor for any adverse effects and ensure the medication is working as intended.

What should I know about storage and disposal of this medication?

Storage and Disposal of Testosterone Topical:

• Storage:
  • Store at room temperature, away from excess heat and moisture. Typically, this means keeping it between 68°F to 77°F (20°C to 25°C).
  • Keep the medication in its original container, tightly closed.
  • Keep out of reach of children.
• Disposal:
  • Dispose of unused or expired medication through a drug take-back program if available. If a take-back program is not available, follow your community’s drug disposal guidelines.
  • Some testosterone topical products may have specific disposal instructions. Check the medication label or consult with a pharmacist.

In case of emergency/overdose

• Symptoms: Overdose symptoms can include nausea, vomiting, and increased or decreased libido. In severe cases, it might cause severe mood swings, aggression, or other symptoms.
• Action: If an overdose is suspected, contact emergency services or go to the nearest emergency room immediately. Be prepared to provide details about the product and the amount used.

What other information should I know?

• Application: Apply the medication to clean, dry skin, usually to the upper arms, shoulders, or abdomen. Avoid application to areas that will be covered by tight clothing.
• Avoid Contact: After application, avoid direct skin contact with others, especially women and children, to prevent inadvertent exposure.
• Monitoring: Regular follow-ups with your healthcare provider are essential to monitor for side effects and ensure the treatment is working effectively.

If you have any specific concerns or need further details, consulting with your healthcare provider or pharmacist is always a good idea.