Adults with polyneuropathy caused by familial transthyretin-mediated amyloidosis (a disorder in which aberrant proteins accumulate and deposit in tissues, causing nerve damage) are treated with vutrisiran. Vutrisiran belongs to the class of drugs known as short interfering RNAs (siRNAs). The amount of faulty proteins and the amount of abnormal protein deposited in the body’s tissues are reduced, which lessens nerve damage.

A solution (liquid) form of vutrisiran injection is available for subcutaneous administration (under the skin). Every three months, a doctor or nurse will typically administer it in a clinic.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before receiving vutrisiran injection,

• If you have an allergy to vutrisiran, any other drugs, or any of the ingredients in vutrisiran injection, let your doctor and pharmacist know right away. Request a list of the components from your pharmacist.
• While using vutrisiran, be sure to let your doctor and pharmacist know what prescription and over-the-counter drugs, vitamins, herbal items, and nutritional supplements you are currently taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• Inform your doctor if you have renal illness, liver disease, or low vitamin A levels now or in the past.
• Your body’s levels of vitamin A may drop if you use vutrisiran. During the administration of vutrisiran injection, your doctor could advise you to take a vitamin A supplement.
• Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Vutrisiran’s effects on the developing foetus are unknown, but since low vitamin A levels might interfere with growth, the advantages and dangers of becoming pregnant while taking vutrisiran should be discussed with your doctor. Call your doctor if you get pregnant while having a vutrisiran injection.

Keep eating normally unless your doctor instructs you otherwise.

Vutrisiran injection should be administered as soon as possible if it was missed, and then your normal dose plan should be resumed.

Side effects from vutrisiran could exist. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Aching joints
• Breathing difficulty
• At the injection site, there may be bruising, discomfort, swelling, redness, itching, and warmth

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs while getting vutrisiran:

• Perceiving challenges at night or in poor light
• Abnormal heartbeat

Other adverse effects of vutrisiran could exist. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep all of your appointments with your physician and the lab.

Ask any queries you may have regarding vutrisiran to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.