Why is this medication prescribed?

Amvuttra, which contains the generic drug vutrisiran, is used primarily for the treatment of hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) with polyneuropathy. This condition involves the buildup of abnormal proteins called amyloid in various tissues, which can lead to neurological issues and other symptoms.

How should this medicine be used?

Here’s how Amvuttra is typically used:

• Administration: Amvuttra is administered as an injection. It is usually given subcutaneously (under the skin) in the thigh or abdomen.
• Dosing Schedule: The standard dosing schedule is one injection every 3 months. Your healthcare provider will determine the appropriate dosage and frequency based on your specific condition.
• Preparation and Injection: The medication should be prepared and administered by a healthcare professional to ensure proper technique and hygiene.
• Monitoring: Regular monitoring by your healthcare provider is necessary to assess the effectiveness of the treatment and to manage any potential side effects.
• Storage: Amvuttra should be stored in the refrigerator. It should not be frozen. Allow the medication to reach room temperature before administration.

Always follow your healthcare provider’s instructions regarding the use of Amvuttra, and consult them if you have any questions or concerns about the treatment.

Other uses for this medicine

Amvuttra (vutrisiran) is specifically approved for the treatment of hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) with polyneuropathy. As of now, its primary use is for this condition, and it may not have other approved indications outside of this context. Always consult with your healthcare provider for the most accurate and personalized information.

What special precautions should I follow?

Special Precautions to Follow:

• Allergic Reactions: Inform your healthcare provider if you have any history of allergic reactions to medications or injectable products. Amvuttra can potentially cause allergic reactions, so it’s important to monitor for any symptoms such as rash, itching, or swelling.
• Liver Function: Regular liver function tests may be required since Amvuttra can affect liver function. Inform your doctor if you have liver disease or if you experience symptoms such as jaundice (yellowing of the skin or eyes) or dark urine.
• Pregnancy and Breastfeeding: Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The effects of Amvuttra during pregnancy and breastfeeding are not well-established, so it’s important to weigh the risks and benefits.
• Other Medications: Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs and supplements. Some medications might interact with Amvuttra.
• Injection Site Reactions: Be aware of possible reactions at the injection site, such as redness, swelling, or discomfort. Report these to your healthcare provider if they occur.
• Monitoring: Follow up with regular appointments for monitoring the effectiveness of the treatment and to address any potential side effects.

Always adhere to your healthcare provider’s advice and report any concerns or side effects promptly.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Amvuttra. However, maintaining a balanced diet and staying hydrated can support overall health and may be beneficial during your treatment. Always follow your healthcare provider’s general dietary advice.

What should I do if I forget a dose?

• Missed Dose: If you miss a dose, contact your healthcare provider for instructions on how to proceed. They will advise you on whether to reschedule the missed dose or wait until your next scheduled dose.
• Timing: Generally, it’s important to stick to the prescribed dosing schedule. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Amvuttra (vutrisiran) can cause various side effects. While not everyone experiences side effects, it’s important to be aware of them. Common and less common side effects include:

Common Side Effects:

• Injection Site Reactions: Redness, pain, swelling, or itching at the site of injection.
• Headache: Some people may experience headaches during treatment.
• Fatigue: Feeling unusually tired or weak.

Serious Side Effects:

• Liver Issues: Symptoms like yellowing of the skin or eyes (jaundice), dark urine, or severe abdominal pain could indicate liver problems. Regular liver function tests are often needed.
• Allergic Reactions: Severe allergic reactions, including rash, itching, swelling, or difficulty breathing.
• Kidney Problems: While less common, monitor for signs of kidney issues, especially if you have a history of kidney disease.
• Nausea: Some patients might experience nausea.
• Abdominal Pain: Discomfort or pain in the abdominal area.

If you experience any of these side effects or any other symptoms that concern you, it’s important to contact your healthcare provider promptly. They can help manage side effects and adjust your treatment if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Amvuttra:

• Storage:
  • Store Amvuttra in the refrigerator at 36°F to 46°F (2°C to 8°C). Do not freeze.
  • Keep the medication in its original packaging to protect it from light.
  • Allow the medication to reach room temperature before administering, but do not heat it.
• Disposal:
  • Dispose of any unused or expired medication as per local regulations. Your healthcare provider or pharmacist can provide guidance on proper disposal.
  • Consider using medication take-back programs or drop-off sites if available in your area.

In case of emergency/overdose

• Emergency: If you suspect an overdose or experience severe symptoms related to Amvuttra, seek emergency medical attention immediately. Symptoms of an overdose may not always be obvious, but prompt medical intervention is crucial.
• Contact Information: Contact your healthcare provider or local poison control center for specific advice and immediate assistance if you have concerns about a potential overdose.

What other information should I know?

• Effectiveness Monitoring: Regular follow-up appointments are necessary to monitor the effectiveness of Amvuttra and to adjust treatment as needed.
• Interaction with Other Medications: Always inform your healthcare provider about all other medications, including over-the-counter drugs and supplements, to avoid potential interactions.
• Reporting Side Effects: Report any side effects or unusual symptoms to your healthcare provider. They can help manage side effects and provide support throughout your treatment.
• Medical History: Inform your healthcare provider about your full medical history, including any liver or kidney issues, to ensure that Amvuttra is appropriate for you.
• Pregnancy and Breastfeeding: Discuss the risks and benefits of Amvuttra with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

Always follow your healthcare provider’s instructions and guidelines to ensure safe and effective use of Amvuttra.