WARNING

Taking Amtagvi (lifileucel) involves several risks, including:

• Infection Risk: Increased risk due to potential impact on your immune system.
• Cytokine Release Syndrome (CRS): Severe inflammation causing symptoms like fever and low blood pressure.
• Neurotoxicity: Possible neurological effects such as confusion or seizures.
• Allergic Reactions: Potential for severe allergic responses including rash, difficulty breathing, or swelling.
• Organ Effects: Rare but possible effects on organs such as the liver or kidneys.

Close monitoring and communication with your healthcare provider are essential to manage these risks effectively.

Why is this medication prescribed?

Amtagvi (generic name: lifileucel) is a type of cancer immunotherapy. It’s a cell-based therapy used for treating certain cancers. Specifically, it targets cancer cells by using modified immune cells that are designed to recognize and attack cancer cells. Amtagvi is often prescribed for Cancer Treatment. It may be used for specific types of cancer, such as relapsed or refractory cancers where other treatments have not been effective.

How should this medicine be used?

Amtagvi is a brand name for the drug Amivantamab, which is used in the treatment of certain types of non-small cell lung cancer (NSCLC) that have specific genetic mutations. Here’s how it’s typically used:

• Administration: Amtagvi is administered via intravenous (IV) infusion. The infusion is usually given by a healthcare professional in a medical setting, such as a hospital or clinic.
• Dosage: The dosage and frequency of Amtagvi depend on your specific condition, overall health, and response to treatment. Your healthcare provider will determine the exact dosage for you.
• Infusion Schedule: The infusion is often given in a cycle, which may involve several weeks of treatment followed by a period of rest. Your healthcare provider will provide a detailed schedule.
• Pre-Medication: Before the infusion, you might receive medications to help prevent or reduce side effects, such as antihistamines or corticosteroids.
• Monitoring: During and after the infusion, you’ll be monitored for any potential side effects or reactions.
• Follow-Up: Regular follow-up appointments will be necessary to assess the effectiveness of the treatment and manage any side effects.

Make sure to discuss any concerns or questions with your healthcare provider to ensure the treatment is tailored to your needs.

Other uses for this medicine

Amtagvi (lifileucel) is primarily used for treating certain types of cancers, particularly advanced or metastatic solid tumors. As of now, it’s mainly prescribed for this purpose, but research and clinical trials may explore additional uses over time.

What special precautions should I follow?

When using Amtagvi (Amivantamab), there are several special precautions to keep in mind:

• Allergic Reactions: Monitor for signs of allergic reactions, such as rash, itching, swelling, or difficulty breathing. Report any such symptoms to your healthcare provider immediately.
• Infusion-Related Reactions: Be aware of potential infusion-related reactions, which can include fever, chills, nausea, or headache. Your healthcare provider may administer medications to manage these reactions.
• Pre-Medication: Follow any pre-medication instructions provided by your healthcare provider to minimize the risk of infusion-related reactions.
• Lung Problems: Amivantamab can affect lung function. Inform your healthcare provider if you experience symptoms like shortness of breath or persistent cough.
• Eye Problems: Report any eye symptoms such as dry eyes, blurred vision, or eye pain, as Amivantamab may cause eye problems.
• Infections: Be vigilant about signs of infection, such as fever or sore throat. Amivantamab may increase the risk of infections.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, plan to become pregnant, or are breastfeeding. Amivantamab may affect fetal development or be excreted in breast milk.
• Other Medications: Share information about all other medications and supplements you are taking, as they might interact with Amivantamab.

Always follow the specific instructions provided by your healthcare provider and report any unusual symptoms or side effects promptly.

What special dietary instructions should I follow?

• No Specific Diet: There are no universal dietary restrictions specifically associated with Amtagvi. However, maintaining a balanced diet to support overall health is important.
• Hydration: Stay well-hydrated, as good hydration can help manage some side effects and support your overall well-being.
• Consult Your Provider: Follow any additional dietary advice given by your healthcare provider based on your individual health needs and any other medications or treatments you may be undergoing.

What should I do if I forget a dose?

Amtagvi is typically administered as a one-time infusion rather than in multiple doses. If you have any concerns about the timing or administration of your treatment, contact your healthcare provider immediately.

What side effects can this medication cause?

Amtagvi (lifileucel) can cause a range of side effects, as with most advanced cancer therapies. The side effects can vary from mild to severe. Here are some potential side effects associated with Amtagvi:

Common Side Effects:

• Fever: One of the most common reactions, often seen after the infusion.
• Fatigue: Feeling tired or weak is frequent and can affect daily activities.
• Chills: Similar to fever, chills can occur and may require management.
• Nausea: You might experience nausea, which can be managed with medication.
• Infusion Reactions: Symptoms such as rash, itching, or redness at the infusion site.

Serious Side Effects:

• Cytokine Release Syndrome (CRS): This is a potentially severe condition caused by the immune system’s response to the treatment. Symptoms may include:
  • High fever
  • Rapid heartbeat
  • Low blood pressure
  • Difficulty breathing
  • Nausea or vomiting
  • Severe fatigue
• Neurotoxicity: This can affect the nervous system and may present as:
  • Confusion
  • Difficulty speaking or understanding
  • Seizures
  • Changes in consciousness or alertness
• Infections: Since the treatment may impact your immune system, there’s an increased risk of infections.
• Organ Effects: Rarely, there may be effects on organs such as the liver or kidneys, which would be monitored by your healthcare team.
• Regular Monitoring: Close monitoring by your healthcare provider is essential to manage and mitigate these side effects.
• Immediate Reporting: Report any severe or concerning symptoms to your healthcare provider immediately.

Always consult your healthcare provider for personalized advice and support in managing side effects and for any specific instructions related to your treatment with Amtagvi.

What should I know about storage and disposal of this medication?

Storage and Disposal of Amtagvi:

• Healthcare Facility: Amtagvi is typically handled and administered in a healthcare facility where it is stored according to specific guidelines until it is used.
• Conditions: The exact storage conditions for Amtagvi (e.g., temperature, light protection) are managed by the healthcare provider or facility. It is crucial to adhere to these conditions to ensure the treatment’s effectiveness.
• Medical Waste: Since Amtagvi is a specialized treatment, its disposal is handled as medical waste by the healthcare facility. You do not need to dispose of the treatment yourself.
• Follow Facility Protocols: If you have any unused or leftover medication, consult your healthcare provider or the facility for guidance on disposal.

In case of emergency/overdose

• Seek Immediate Help: If you experience severe side effects or an allergic reaction, seek emergency medical attention immediately. Symptoms to watch for include severe fever, difficulty breathing, confusion, or any other serious reactions.
• Contact Healthcare Provider: Notify your healthcare provider or the facility where you received the treatment about any significant issues as soon as possible.
• Treatment: Overdose scenarios are unlikely since Amtagvi is typically administered as a one-time infusion. However, if there are concerns about an overdose or adverse reactions, medical professionals at the treatment center will manage the situation.
• Monitoring: Follow-up appointments will help monitor for any adverse effects and manage them appropriately.

What other information should I know?

• Health Assessment: Ensure thorough pre-treatment evaluation to determine suitability for Amtagvi and address any potential health issues.
• Ongoing Evaluation: Your healthcare team will evaluate the effectiveness of the treatment and make any necessary adjustments.
• Manage Side Effects: Supportive care and medications may be provided to manage side effects and improve comfort.
• Inform Healthcare Providers: Keep your healthcare providers informed about any changes in your condition or new symptoms that arise.
• Regular Check-Ups: Attend all scheduled follow-up appointments to ensure proper monitoring and management of your treatment.

Always follow the guidance provided by your healthcare team for the specific management of Amtagvi. They will provide detailed instructions tailored to your individual needs and circumstances.