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Allopurinol Injection

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Why is this medication prescribed?

People with certain types of cancer who are receiving chemotherapy drugs but are unable to take oral allopurinol are treated with high levels of uric acid (a natural chemical that builds up in the blood as tumours break down), which is addressed with allopurinol injection. Allopurinol belongs to the group of drugs known as xanthine oxidase inhibitors. It functions by lessening the body’s ability to produce uric acid.

How should this medicine be used?

Powdered allopurinol is available for intravenous injection; it must be combined with fluids (into a vein). It may be injected every 6, 8, or 12 hours, but it is typically administered once per day. Typically, an injection of allopurinol is administered 24 to 48 hours before chemotherapy begins.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving allopurinol injection,

  • If you have any allergies, including to any of the ingredients in allopurinol injection, notify your doctor and pharmacist right away. Request a list of the components from your pharmacist.
  • While receiving an allopurinol injection, be sure to let your doctor and pharmacist know what prescription and over-the-counter medicines, vitamins, herbal remedies, and nutritional supplements you are taking. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your physician if you have high blood pressure, diabetes, renal or liver disease, or heart failure now or in the past.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you get pregnant while having allopurinol injectable.
  • You ought to be aware that allopurinol might make you feel sleepy. Prior to understanding how this drug affects you, avoid using machinery or driving a car.

What special dietary instructions should I follow?

Unless your doctor instructs you otherwise, consume at least eight 8-ounce (240 millilitre) cups of water or other liquids every day while taking allopurinol.

What side effects can this medication cause?

Side effects from allopurinol injection are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • An injection location that hurts or itches
  • Nausea
  • Diarrhea
  • Drowsiness

Some adverse effects can be very harmful. Call your doctor right away if you develop any of these symptoms, or seek emergency medical attention:

  • Hives, itching, or a rash
  • Skin that is flaking, blistering, or shedding
  • Skin with purple or red dots
  • Unpleasant urination
  • Urine with blood in it
  • Itchiness in the eyes
  • Swelling of the mouth or lips
  • Flu-like symptoms or a fever
  • Enlarged glands
  • Yellowing of the skin or eyes, discomfort in the right upper abdomen, nauseousness, vomiting, itching, or extreme exhaustion

Other negative effects from allopurinol injection are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the allopurinol injection, your doctor will request a few lab tests.

Inform the lab staff and your doctor that you are receiving an allopurinol injection prior to any laboratory test.

Any queries you may have regarding allopurinol injection, ask your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Aloprim®
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