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Akynzeo (Generic Netupitant and Palonosetron)

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Why is this medication prescribed?

To stop nausea and vomiting brought on by cancer treatment, netupitant and palonosetron are combined. The drug Netupitant belongs to a group of drugs known as neurokinin (NK1) antagonists. It functions by preventing neurokinin, a brain chemical that naturally induces nausea and vomiting. Palonosetron belongs to a group of drugs known as 5-HT3 receptor antagonists. It functions by preventing serotonin, a chemical produced naturally by the body that triggers nausea and vomiting.

How should this medicine be used?

The oral pill containing netupitant and palonosetron is available. It is typically given with or without food about an hour before to the commencement of chemotherapy. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Take palonosetron and netupitant exactly as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking netupitant and palonosetron,

  • If you have an allergy to netupitant, palonosetron, alosetron (Lotronex), dolasetron (Anzemet), granisetron (Sancuso), ondansetron (Zofran, Zuplenz), any other medications, or any of the substances in netupitant and palonosetron capsules, let your doctor and pharmacist know right once. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any vitamins, nutritional supplements, herbal items, and prescription and over-the-counter drugs you are using. Any of the following should be mentioned: benzodiazepines such midazolam (Xanax), triazolam (Halcion), and alprazolam (Xanax); some chemotherapy drugs like vinblastine, vincristine, and vinorelbine (Navelbine); cyclophosphamide (Cytoxan); docetaxel (Docefrez, Taxotere); etoposide; ifosfamide (Ifex); imatinib, drugs to treat migraines like almotriptan (Axert), eletriptan (Relpax), and frovatriptan; erythromycin (E.E.S., Ery-tab, etc); fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis, Subsys); ketoconazole (Nizoral); lithium (Lithobid); (Frova), methylene blue, mirtazapine (Remeron), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), linezolid (Zyvox), and phenelzine; and methylene blue (Nardil), selective serotonin reuptake inhibitors (SSRIs) like citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft), as well as phenobarbital, rif (Conzip, Ultram, in Ultracet). The dosage of your drugs may need to be adjusted, and your health may need to be closely watched for any negative effects.
  • If you have or have previously had liver or kidney disease, let your doctor know.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you become pregnant while taking netupitant and palonosetron.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Only use netupitant and palonosetron as directed by your doctor prior to chemotherapy. It shouldn’t be consumed on a regular basis.

What side effects can this medication cause?

Palonosetron and netupitant both have potential adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Abdominal pain
  • Heartburn
  • Constipation
  • Weakness
  • Skin that is flaming red

Some adverse effects can be very harmful. Call your doctor right away or go to an emergency room if you notice any of the following symptoms:

  • Hives
  • Rash
  • Itching
  • Breathing or swallowing challenges
  • Breathing difficulty
  • Fainting, feeling lightheaded, and dizzy
  • Irregular, fast, or sluggish heartbeat
  • Agitation
  • Hallucinations (seeing things or hearing sounds and voices that do not exist)
  • Fever
  • Flushing
  • Excessive perspiration
  • Confusion
  • Diarrhoea, vomiting, and nauseous
  • Inability to coordinate
  • Twitching or stiff muscles
  • Seizures
  • Coma (loss of consciousness)

Other adverse effects could be brought on by palonosetron and netupitant. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from light, excessive heat, and moisture at room temperature (not in the bathroom). Medication that has expired or is no longer required should be thrown away. Consult your pharmacist for advice on how to properly dispose of your medications.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

What other information should I know?

Keep all of your doctor’s appointments.

No one else should take your medication.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Akynzeo®
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