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Aklief (Generic Trifarotene Topical)

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Why is this medication prescribed?

Acne is treated with trifarotene in both adults and children older than 9 years old. Trifarotene belongs to the group of drugs known as retinoids. It functions by encouraging the peeling of the damaged skin, clearing the pores, and stopping the development of fresh pimples beneath the epidermis.

How should this medicine be used?

Trifarotene is available as a skin-applying cream. Typically, it is used once daily, before bed. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow the trifarotene instructions exactly. Use it only as directed by your doctor, neither more nor less often.

Only the skin of your face (forehead, nose, each cheek, and chin) or upper trunk may be treated with trifarotene cream (upper back, shoulders and chest). Trifarotene must not be allowed to enter the mouth, corners of the nose, eyes, ears, or vagina. Apply sparingly to eczema, wounds, and sunburnt skin.

Trifarotene cream is packaged in a pump bottle with usage guidelines. Please carefully read and adhere to these directions. Before applying, gently clean the afflicted area and pat it dry. To the skin that is afflicted on the face, chest, shoulders, or back, apply a thin coating of the cream. If you have any queries about how to use trifarotene cream, consult your physician or pharmacist.

Avoid using trifarotene cream with abrasive products, alcohol-based cleansers, or non-prescription or prescription cosmetics (e.g., shaving lotions, astringents, and perfumes).

During the initial four weeks of your treatment, your skin may feel dry or sensitive. Speak with your doctor if your skin ever stings, burns, or becomes irritated while you are receiving therapy. To deal with dryness, your doctor might advise using a moisturiser or suggesting using it less frequently.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using trifarotene,

  • If you have an allergy to trifarotene, any other drugs, or any of the ingredients in trifarotene cream, let your doctor and pharmacist know right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have or have ever had eczema, let your doctor know (a skin disease).
  • If you are breastfeeding a child or intend to become pregnant, let your doctor know. Call your doctor if you become pregnant while taking trifarotene. Use the least amount of trifarotene possible during breastfeeding, and avoid applying it directly to the nipple and areola (the coloured area around each nipple).
  • Plan to use protective clothing, sunglasses, and sunscreen with an SPF of 15 or higher and to prevent unnecessary or prolonged exposure to sunlight or UV light (tanning beds and sunlamps). Your skin may become more susceptible to ultraviolet or sunlight if you use trifarotene.
  • During your course of trifarotene treatment, avoid using hot wax to remove unwanted hair from the area being treated.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

As soon as you realise you missed a dose, administer it. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. Applying extra cream won’t make up for a forgotten dose.

What side effects can this medication cause?

Trifarotene could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Skin at the treatment site that is dry, painful, burning, stinging, peeling, red, itchy, or flaky

Other negative effects of trifarotene are possible. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call your local poison control centre at 1-800-222-1222 if someone consumes trifarotene. Dial 911 to reach the nearest emergency services if the sufferer has collapsed or has stopped breathing.

What other information should I know?

Keep all of your doctor’s appointments.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Aklief®
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