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Ajovy (Generic Fremanezumab-vfrm Injection)

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Why is this medication prescribed?

Use the injection fremanezumab-vfrm to help with migraine prevention (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light). Fremanezumab-vfrm injection belongs to a class of medications known as monoclonal antibodies. It works by preventing the body’s natural material from making the chemical that causes migraines.

How should this medicine be used?

Both a prefilled autoinjector for subcutaneous injection and a solution (liquid) form of fremanezumab-vfrm injection are available (under the skin). Usually, it is injected once a month or once every three months (as 3 separate injections given one right after the other). Use fremanezumab-vfrm injectable every one to three months, depending on your dose, on or around the same day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow their instructions. Exactly as instructed, administer fremanezumab-vfrm injection. Use only as directed by your doctor, neither more nor less of it, nor more frequently.

You might be able to administer the medication yourself at home, or you might ask a friend or family member to do it for you. Ask your doctor to demonstrate how to inject the medication to you or the person giving the shots.

Both a prefilled syringe and a prefilled autoinjector are available for the injection of fremanezumab-vfrm. Before injecting the medication, let the syringe and autoinjector reheat to room temperature for 30 minutes away from direct sunlight. Never attempt to reheat the drug by putting it in a hot water bath, microwave, or any other device. Use each syringe or autoinjector just once, and inject the entire amount of solution it holds. Put spent syringes or the autoinjector in a container that won’t puncture. How to get rid of the puncture-resistant container should be discussed with your doctor or pharmacist.

Fenonezumab-vfrm should be injected into the upper arm, stomach, or thigh. Injecting into skin that is soft, thick, bruised, red, scaly, hard, or that contains scars or stretch marks is not advised.

Before injecting fremanezumab-vfrm, always have a look at it. It need to be transparent and colourless. If the fremanezumab-vfrm injection is coloured, hazy, has flakes, or has solid particles in it, do not use it. Never shake it.

Use a different syringe or autoinjector for each injection if your doctor instructs you to administer three different shots consecutively. Make sure that each injection is not administered at the exact same location as the others if you administer them at the same body site (upper arm, thigh, or stomach).

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using fremanezumab-vfrm injection,

  • If you have an allergy to fremanezumab-vfrm, any other drugs, or any of the ingredients in fremanezumab-vfrm injection, notify your doctor right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while receiving fremanezumab-vfrm injection.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you don’t remember to take your medication at the scheduled time, take it as soon as you do. From the day of your last dose forward, resume your dosing regimen.

What side effects can this medication cause?

The injection of fremanezumab-vfrm may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Pain, erythema, or edoema at the injection location

You can have some serious side effects for as long as a month after your injection. If you see any of these symptoms, call your doctor straight away or go to the emergency room:

  • Your face, mouth, tongue, or throat swelling
  • Having trouble breathing
  • Rash
  • Itching
  • Hives

Other negative effects from the injection of fremanezumab-vfrm are possible. If you have any strange side effects while taking this medicine, contact your doctor right once.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or over the phone if you suffer a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly wrapped, away from children, and in the original container it came in. Do not freeze it; instead, keep it in the refrigerator. The drug may be kept at room temperature in the original carton for up to 24 hours after being taken out of the fridge. If the fremanezumab-vfrm injection has been stored at room temperature for longer than 24 hours, dispose of it.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your doctor’s appointments.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Ajovy®
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