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Aggrenox (Generic Aspirin and Extended-Release Dipyridamole)

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Why is this medication prescribed?

Aspirin and extended-release dipyridamole belong to a group of medications known as antiplatelet agents. It functions by limiting overly rapid blood coagulation. Patients who have experienced a stroke or are at risk of one can use it to lower their risk of having one.

How should this medicine be used?

An oral capsule containing aspirin and extended-release dipyridamole is available. One capsule is typically taken in the morning and one in the evening. Take the extended-release dipyridamole and aspirin whole. Avoid opening, breaking, crushing, or chewing the capsules.

Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Take extended-release dipyridamole and aspirin precisely as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Aspirin and extended-release dipyridamole reduce but do not completely eliminate the chance of suffering a stroke. Even if you feel good, keep taking the extended-release dipyridamole and aspirin. Without consulting your doctor, do not discontinue taking aspirin and extended-release dipyridamole.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking aspirin and extended-release dipyridamole,

  • Inform your doctor and pharmacist if you have any allergies to aspirin, celecoxib (Celebrex), choline salicylate (Arthropan), diclofenac (Cataflam), diflunisal (Dolobid), dipyridamole (Persantine), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), Magnesium salicylate (Nuprin Backache, Doan’s), meclofenamate, mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), or any other drugs.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: acetazolamide (Diamox); ambenonium (Mytelase); angiotensin-converting enzyme inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), trandolapril (Mavik), quinapril (Accupril), and ramipril (Altace); anticoagulants (sometimes known as “blood thinners”) like warfarin (Coumadin) and heparin; beta-blockers including acebutolol (Sectral), atenolol (Tenormin), betaxolol (Kerlone), bisoprolol (Zebeta), carteolol (Cartrol), carvedilol (Coreg), labetalol (Normodyne), metoprolol (Lopressor), nadolol (Corgard), penbutolol (Levatol); acetohexamide (Dymelor), chlorpropamide (Diabinese), glimepiride (Amaryl), glipizide (Glucotrol), glyburide (DiaBeta, Micronase, Glynase), repaglinide (Prandin), tolazamide (Tolinase), and tolbutamide (Orinase) are examples of diabetes drugs. Diuretics (also known as “water pills”) include amiloride (Midamor), bumetanide (Bumex), chlorothiazide (Diuril), chlorthalidone (Hygroton), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (Hydrodiuril), indapamide (Lozol), metolazone (Zaroxo (Celebrex), Ibuprofen (Advil, Motrin, Nuprin, etc.), fenoprofen (Nalfon), flurbiprofen (Ansaid), ketoprofen (Orudis, Oruvail), ketorolac (Toradol), magnesium salicylate (Nuprin Backache, Doan’s), meclofenamate, mefenamic acid (Ponstel), meloxicam (Mobic), n (Depakene, Depakote).
  • If you have or have had had liver, kidney, or heart illness, a recent heart attack, bleeding disorders, low blood pressure, vitamin K deficiency, ulcers, the syndrome of asthma, rhinitis, and nasal polyps, or if you consume three or more alcoholic beverages per day, let your doctor know.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor right away if you become pregnant while taking aspirin or extended-release dipyridamole.
  • Inform your doctor or dentist that you are taking aspirin and extended-release dipyridamole if you are having surgery, including dental surgery. Before surgery, your doctor could advise you to stop using extended-release dipyridamole and aspirin.

What special dietary instructions should I follow?

Maintain your regular diet while taking aspirin and extended-release dipyridamole, unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Aspirin and extended-release dipyridamole both have potential side effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Heartburn
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Joint and muscle ache
  • Tiredness

Call your doctor right away if you have any of the following symptoms:

  • Bleeding
  • Extreme rash
  • Lips, tongue, or mouth swelling
  • Having trouble breathing
  • Warm sensation
  • Flushing
  • Sweating
  • Restlessness
  • Weakness
  • Dizziness
  • Chest pain
  • A quick heartbeat
  • An earache that ringers

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

The combination product of aspirin and extended-release dipyridamole (Persantine) should not be substituted for the separate components.

Keep all of your appointments with your physician and the lab. To determine how you are responding to aspirin and extended-release dipyridamole, your doctor may request specific lab tests.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

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