Why is this medication prescribed?

Agalsidase beta is a medication used to treat Fabry disease, a rare genetic disorder that affects various organs and systems in the body. Fabry disease is caused by a deficiency of an enzyme called alpha-galactosidase A. Agalsidase beta is a form of this enzyme that helps to break down certain substances that build up in the body due to the deficiency.

How should this medicine be used?

Agalsidase beta Injection should be used exactly as prescribed by a healthcare provider. Here are general guidelines for its use:

• Administration: Agalsidase beta is administered via intravenous (IV) infusion. It is typically given in a healthcare setting by a trained professional.
• Dosage: The dosage and frequency of administration are determined by your healthcare provider. It is usually given every 2 weeks.
• Preparation: The medication must be prepared and diluted according to specific guidelines provided by the manufacturer. This is generally done by the healthcare provider or pharmacist.
• Monitoring: Regular monitoring is essential to assess the effectiveness of the treatment and to check for any potential side effects.
• Precautions: Inform your healthcare provider about any other medications you are taking, as well as any allergies or medical conditions you have.

Always follow your healthcare provider’s instructions regarding the use of Agalsidase beta and discuss any concerns or questions you might have with them.

Other uses for this medicine

Agalsidase beta is primarily used for treating Fabry disease. As of now, its use is generally limited to this condition. It is not commonly used for other conditions or off-label purposes. Always follow your healthcare provider’s guidance regarding its use.

What special precautions should I follow?

Special Precautions for Agalsidase Beta Injection:

• Allergic Reactions: Inform your healthcare provider if you have a history of allergies, especially to medications or enzyme therapies, as allergic reactions can occur.
• Infusion-Related Reactions: Watch for symptoms of infusion-related reactions, such as fever, chills, nausea, or rash. If any of these symptoms occur, notify your healthcare provider immediately.
• Kidney Function: Since Fabry disease can affect kidney function, your healthcare provider may monitor your renal function regularly.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss with your healthcare provider whether Agalsidase beta is safe for you.
• Pre-existing Conditions: Notify your healthcare provider of any other medical conditions you have, including heart disease or liver problems, as these may impact how you respond to the medication.
• Interactions with Other Medications: Inform your healthcare provider of all other medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.

Always follow the specific instructions provided by your healthcare provider and report any side effects or concerns promptly.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Agalsidase beta. However, maintaining a balanced diet and staying hydrated can support overall health and may help manage any side effects.

What should I do if I forget a dose?

If you miss a dose of Agalsidase beta, contact your healthcare provider as soon as possible for instructions. They will provide guidance on how to proceed, which may involve rescheduling the missed dose or adjusting your treatment plan. Do not attempt to double up on doses to make up for a missed one without professional advice.

What side effects can this medication cause?

Agalsidase beta can cause a range of side effects. Some common and less serious side effects include:

• Infusion-Related Reactions: These can include symptoms such as fever, chills, nausea, headache, rash, or itching. These reactions often occur during or shortly after the infusion.
• Fatigue: Some people may feel unusually tired or weak after receiving the infusion.
• Muscle and Joint Pain: Mild pain or discomfort in muscles or joints may occur.
• Digestive Issues: This can include nausea, vomiting, or diarrhea.
• Flu-like Symptoms: These symptoms may include a sore throat, cough, or runny nose.

Less common but more serious side effects may include:

• Severe Allergic Reactions: Symptoms can include severe rash, itching, swelling, dizziness, or difficulty breathing. Seek immediate medical attention if you experience any of these symptoms.
• Anaphylaxis: A severe, potentially life-threatening allergic reaction that requires immediate medical intervention.
• Severe Infusion Reactions: In rare cases, some people may experience severe reactions such as difficulty breathing or chest pain.

Always inform your healthcare provider if you experience any side effects, especially if they are severe or persistent. They can provide guidance on how to manage side effects and adjust your treatment if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Agalsidase Beta Injection:

Storage:

• Store Agalsidase beta in the refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze the medication.
• Keep the medication in its original packaging to protect it from light.
• Do not shake the vial or mix it vigorously, as this could damage the medication.
• Check the expiration date on the vial and do not use the medication past this date.

Disposal:

• Dispose of any unused or expired medication according to your healthcare provider’s instructions or local disposal regulations.
• Some pharmacies offer take-back programs for unused medications.
• If no take-back program is available, follow specific local guidelines for disposing of medications in household trash. This often involves mixing the medication with an undesirable substance (like coffee grounds) and placing it in a sealed container.

In case of emergency/overdose

• If you experience severe allergic reactions, difficulty breathing, or other serious symptoms, seek immediate medical help.
• Call your local poison control center or emergency services if you suspect an overdose.
• Inform your healthcare provider immediately if you suspect an overdose or if you have any concerns about your dosage.

What other information should I know?

• Regular Monitoring: Attend all scheduled appointments and monitoring tests to assess the effectiveness of the treatment and check for any potential side effects.
• Record Keeping: Keep a record of your infusions and any side effects you experience. This can be helpful for your healthcare provider in managing your treatment.
• Communication: Maintain open communication with your healthcare provider about any changes in your health, concerns, or questions about the medication.
• Emergency Plan: Have a plan in place for emergencies, including knowing where to seek help and having a list of your current medications and health conditions.

Always follow the specific instructions provided by your healthcare provider and the manufacturer of the medication.