WARNING

Adrucil (generic name Fluorouracil) is a chemotherapy drug used to treat various cancers. Here are some of the key risks associated with its use:

• Bone Marrow Suppression: It can reduce blood cell production, leading to anemia, increased risk of infections, and bleeding problems.
• Gastrointestinal Issues: Nausea, vomiting, diarrhea, and mouth sores are common.
• Skin Reactions: It may cause rash, redness, or peeling of the skin.
• Increased Sensitivity: Patients may be more sensitive to infections and may experience a higher risk of certain types of infections.
• Liver Toxicity: It can affect liver function, potentially leading to liver damage.

Regular monitoring and consultations with a healthcare provider are essential to manage these risks effectively.

Why is this medication prescribed?

Adrucil is prescribed primarily for its effectiveness in treating various types of cancer. It works by interfering with the growth of cancer cells, ultimately leading to their destruction. Some of the cancers it is commonly used to treat include:

• Colorectal Cancer: It is often used as part of a combination therapy for treating cancers of the colon and rectum.
• Breast Cancer: It can be used in combination with other drugs for certain types of breast cancer.
• Stomach Cancer: Adrucil is sometimes used in treating gastric (stomach) cancer.
• Head and Neck Cancers: It may be used for certain cancers in these areas.

The drug is usually part of a broader chemotherapy regimen designed to target and kill cancer cells more effectively.

How should this medicine be used?

Adrucil (Fluorouracil) is administered as an injection, usually into a vein (intravenous or IV). The specifics of how it should be used can vary depending on the treatment plan developed by a healthcare provider. Here’s a general outline of its use:

• Administration: Adrucil is given by a healthcare professional, typically in a hospital or clinic setting. It can be administered as a continuous infusion over several days or as intermittent bolus injections.
• Dosage: The dosage and frequency depend on the type of cancer being treated, the patient’s overall health, and their response to the drug. The healthcare provider will determine the appropriate dosage and schedule.
• Monitoring: Regular monitoring of blood counts, liver function, and overall health is crucial while on Adrucil. This helps manage side effects and adjust the treatment as needed.
• Combination Therapy: It is often used in combination with other chemotherapy drugs. The healthcare provider will outline the complete regimen and schedule.

Patients should follow their healthcare provider’s instructions carefully and report any side effects or unusual symptoms promptly.

Other uses for this medicine

• Anal Cancer: It can be part of a treatment regimen for cancer of the anus.
• Esophageal Cancer: Occasionally used in the treatment of esophageal cancer.
• Pancreatic Cancer: Sometimes included in treatment protocols for pancreatic cancer.

What special precautions should I follow?

Special Precautions for Adrucil Injection:

• Allergies: Inform your healthcare provider if you have any allergies or have had a previous allergic reaction to Fluorouracil or any other medications.
• Medical History: Discuss your complete medical history, especially any history of liver disease, kidney problems, or bone marrow issues.
• Infection Risks: Since Adrucil can lower white blood cell counts, you are at a higher risk of infections. Avoid contact with people who have infections and practice good hygiene.
• Pregnancy and Breastfeeding: Adrucil can be harmful to an unborn baby and should not be used during pregnancy unless absolutely necessary. It can also affect breastfeeding, so consult your healthcare provider if you are pregnant or breastfeeding.
• Drug Interactions: Inform your provider about all other medications and supplements you are taking to avoid potential interactions.
• Hydration and Diet: Maintain good hydration and follow dietary recommendations provided by your healthcare team, as Fluorouracil can cause gastrointestinal side effects.
• Regular Monitoring: Regular blood tests and liver function tests are essential to monitor for side effects and adjust treatment as needed.

Always follow your healthcare provider’s specific instructions and attend all scheduled appointments for monitoring and treatment adjustments.

What special dietary instructions should I follow?

• Hydrate: Drink fluids regularly to stay hydrated, especially if you experience diarrhea or vomiting.
• Avoid Certain Foods: Consult your healthcare provider about any specific dietary restrictions or foods to avoid, especially if you have other health conditions that might interact with the treatment.
• Balanced Diet: Maintain a balanced diet rich in nutrients to support overall health and help your body cope with the effects of the medication.

What should I do if I forget a dose?

• Contact Your Healthcare Provider: If you miss a dose of Adrucil, contact your healthcare provider or pharmacist immediately for guidance on what to do next. Do not attempt to make up for a missed dose on your own.
• Follow Instructions: Your healthcare provider will provide instructions on how to proceed. In some cases, they may schedule a new dose or adjust your treatment plan based on the missed dose.
• Do Not Double Dose: Avoid taking a double dose to compensate for a missed one, as this can increase the risk of side effects

What side effects can this medication cause?

Adrucil (Fluorouracil) can cause a range of side effects. Here are some of the more common and serious ones:

Common Side Effects:

• Gastrointestinal Issues: Nausea, vomiting, diarrhea, and mouth sores.
• Fatigue: General feeling of tiredness or weakness.
• Loss of Appetite: Reduced desire to eat.
• Skin Reactions: Rash, redness, or peeling skin.

Serious Side Effects:

• Bone Marrow Suppression: Can lead to anemia, increased risk of infections, and bleeding issues due to low blood cell counts.
• Liver Problems: Elevated liver enzymes, jaundice (yellowing of the skin and eyes), and liver damage.
• Heart Issues: Rare but can include chest pain or heart rhythm problems.
• Severe Infections: Increased susceptibility to infections due to lowered white blood cell counts
• Neurological Issues: Symptoms like confusion, seizures, or sudden changes in mood or behavior.
• Severe Allergic Reactions: Rash, itching, swelling, severe dizziness, or trouble breathing.

If you experience any severe or concerning symptoms, contact your healthcare provider immediately. They can offer guidance on managing side effects and adjusting treatment if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Adrucil Injection:

• Storage:
  • Temperature: Store Adrucil Injection according to the manufacturer’s guidelines, usually in a controlled room temperature away from light and moisture. Typically, it should be kept at room temperature (20°C to 25°C or 68°F to 77°F).
  • Handling: Keep it out of reach of children and pets. If there are specific storage instructions provided by your healthcare provider or pharmacist, follow those carefully.
• Disposal:
  • Do Not Flush: Do not dispose of Adrucil in the toilet or sink unless instructed to do so by your pharmacist or local waste disposal regulations.
  • Take-Back Programs: Use a drug take-back program or follow your local regulations for proper disposal. Many communities have designated sites or events for safe disposal of medications.
  • Disposal Instructions: Follow any specific disposal instructions given by your healthcare provider or pharmacist.

In case of emergency/overdose

• Contact Medical Help: If you suspect an overdose, seek emergency medical attention immediately. Call your local emergency services or go to the nearest emergency room.
• Symptoms of Overdose: Symptoms might include severe nausea, vomiting, diarrhea, mouth sores, or unusual bleeding/bruising. If you experience any of these symptoms or others that concern you, get medical help right away.
• Emergency Information: Have the medication packaging or prescription information available when you seek emergency care. This helps healthcare providers understand what has been taken and how to treat it.

What other information should I know?

• Regular Monitoring: Keep up with all scheduled appointments for monitoring blood counts, liver function, and overall health while on Adrucil.
• Drug Interactions: Inform your healthcare provider about all other medications, including over-the-counter drugs and supplements, to avoid potential interactions.
• Follow-Up: Adhere to the treatment plan and any specific instructions from your healthcare provider regarding dosage, administration, and side effects.
• Patient Support: If you have questions or concerns about the medication or its side effects, don’t hesitate to contact your healthcare provider or pharmacist for support.
• Documentation: Keep a record of any side effects, changes in symptoms, or other relevant information to discuss with your healthcare provider during follow-ups.

Always consult your healthcare provider or pharmacist if you have specific questions or concerns about your treatment with Adrucil.