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Adrucil Injection (Generic Fluorouracil Injection)

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Fluorouracil injection should be administered in a hospital or other healthcare setting under the guidance of a physician with experience administering chemotherapy drugs for cancer. Fluorouracil injection therapy may have detrimental side effects.

Why is this medication prescribed?

In order to treat colon cancer or rectal cancer (cancer that starts in the large intestine) that has gotten worse or spread to other regions of the body, fluorouracil is typically used in combination with other drugs. After radiation therapy or surgery to remove the tumour, fluorouracil is used in combination with other drugs to treat some forms of breast cancer. Additionally, stomach cancer and pancreatic cancer are both treated with fluorouracil. The drug fluorouracil belongs to the group of drugs known as antimetabolites. It functions by reducing or halting the development of cancer cells within your body.

How should this medicine be used?

A doctor or nurse will administer fluorouracil injection intravenously (into a vein) using a solution (liquid) in a medical setting. The sort of drugs you are taking, how well your body reacts to them, and the type of cancer you have will all affect how long your treatment will last.

If you have certain adverse effects, your doctor can decide to postpone your treatment or alter your dose. It is crucial that you communicate your feelings to your doctor throughout your fluorouracil injectable treatment.

Other uses for this medicine

In addition to treating cancers of the mouth, lip, cheek, tongue, palate, throat, tonsils, and sinuses, fluorouracil is also occasionally used to treat cancers of the cervix (the opening of the uterus) and oesophagus, ovarian cancer (cancer that starts in the female reproductive organs where eggs are formed), and renal cell cancer (RCC, a type of cancer that begins in the kidney). The dangers of using this drug for your illness should be discussed with your doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving fluorouracil,

  • If you have an allergy to fluorouracil or any of the ingredients in fluorouracil injection, let your doctor and pharmacist know right once. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Incorporate any of the following: a number of chemotherapeutic drugs, including cyclophosphamide (Cytoxan), busulfan (Myerlan, Busulfex), carmustine (BiCNU, Gliadel Wafer), ifosfamide (Ifex), lomustine (CeeNU), and melphalan (Alkeran), drugs that inhibit the immune system, such as azathioprine (Imuran), cyclosporine (Neoral, Sandimmune), methotrexate (Rheumatrex), sirolimus (Rapamune), and tacrolimus; procarbazine (Mutalane) or temozolomide (Temodar) (Prograf). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have an infection, tell your doctor. You might not be given an injection of fluorouracil by your doctor.
  • Inform your doctor if you have or have ever had kidney or liver illness, undergone radiation therapy (x-ray), other chemotherapeutic treatment, or both.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. While having fluorouracil injections, you shouldn’t try to get pregnant or breastfeed. Call your doctor if you fall pregnant while receiving fluorouracil injections. The foetus could suffer from fluorouracil.
  • Make a plan to limit your time spent in the sun and to use sunscreen, sunglasses, and protective clothes. Your skin could become sun-sensitive if you take fluorouracil.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Fluorouracil could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Reduced appetite
  • Nausea
  • Unusual weakness or fatigue
  • Dizziness
  • Headache
  • Hair fall
  • Cracked and parched skin
  • Vision alters
  • Teary eyes or eyes that are sensitive to light
  • Redness, discomfort, swelling, or burning at the injection site
  • Confusion

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • In the mouth and throat sores
  • Diarrhea
  • Vomiting
  • Skin on the palms and soles of the feet that is swollen, hurts, red, or begins to peel
  • Infection-related symptoms such as fever, chills, sore throat, or others
  • Hives
  • Rash
  • Itching
  • Breathing or swallowing challenges
  • Nosebleeds
  • Spitting up or coughing up blood or what seems to be coffee grounds
  • Uncommon bruising or bleeding
  • Red, dark brown, or pink urine
  • Reddish-orange or tarry-black stools
  • Chest pain

Other negative effects of fluorouracil are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Nausea
  • Diarrhea
  • Vomiting
  • Infection-related symptoms such as fever, chills, sore throat, or others
  • Uncommon bruising or bleeding
  • Tarry, black, or bloody stools
  • Spitting up or coughing up blood or what seems to be coffee grounds

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor how your body is responding to fluorouracil, your doctor may or may not prescribe specific lab tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Adrucil® Injection
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