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Without consulting your doctor, do not discontinue taking adefovir. Your hepatitis may worsen if you stop using adefovir. The first three months after stopping adefovir are when this is most likely to occur. Take cautious not to forget your medications or run out of adefovir. If you have or have had had a liver condition other than cirrhosis or hepatitis B, let your doctor know (scarring of the liver). Call your doctor right away if you suffer any of the following signs and symptoms after stopping adefovir: Extreme fatigue, weakness, nausea, vomiting, appetite loss, skin or eye yellowing, dark urine, light bowel motions, and discomfort in the muscles or joints.

Adefovir might harm kidney tissue. Inform your doctor if you suffer from kidney disease, high blood pressure, or diabetes now or in the past. Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), cyclosporine (Gengraf, Neoral, Sandimmune), tacrolimus (Prograf), and vancomycin, should all be disclosed to your doctor and pharmacist if you are currently taking any of these medications or have ever taken any of them. Make a quick call to your doctor if you encounter any of the following signs: disorientation, a reduction in urine, or swelling of the hands, feet, ankles, or lower legs.

Adefovir may make treating your HIV infection more challenging if you have AIDS or HIV that is not being treated medically. Inform your doctor if you have HIV or AIDS, engage in unprotected sex with several partners, use injectable street drugs, or have any of these conditions. Before you start adefovir medication and at any point while you are receiving it if there is a potential that you were exposed to HIV, your doctor may do an HIV infection test on you.

Adefovir can harm the liver seriously or even kill you when taken by alone or in conjunction with other antiviral drugs, a condition known as lactic acidosis (a build-up of acid in the blood). If you are a woman, are overweight, or have previously received extensive treatment for hepatitis B virus (HBV) infection, your chance of developing lactic acidosis may be higher. If you have liver illness now or ever had it, let your doctor know. Call your doctor right away if you have any of the following symptoms: confusion; Itching, feeling cold, especially in the arms or legs, unusual bleeding or bruising, yellowing of the skin or eyes, dark urine, light bowel movements, difficulty breathing, stomach pain or swelling, nausea, unusual muscle pain, lack of energy, flu-like symptoms, dizziness or lightheadedness, a rapid or irregular heartbeat, or extreme weakness or exhaustion.

Before, during, and for a few months following your treatment with adefovir, keep all appointments with your doctor and the lab. To monitor your body’s reaction to adefovir throughout this period, your doctor will prescribe specific lab tests.

About the dangers of using adefovir, see your doctor.

Why is this medication prescribed?

Adefovir is used to treat adults and children 12 years of age and older who have chronic (long-term) hepatitis B infection (liver swelling brought on by a virus). Nucleotide analogues are a group of drugs that includes a drug called adefovir. Hepatitis B virus (HBV) levels in the body are lowered as a result of its action. Adefovir may not be able to stop chronic hepatitis B consequences such liver cancer or cirrhosis, though. Hepatitis B is not curable with this medication. Hepatitis B transmission to other persons might not be stopped by adefovir.

How should this medicine be used?

Adefovir is available as an oral tablet. Typically, it is taken once day, with or without food. Adefovir should be taken every day at about the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Adefovir should be taken as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking adefovir,

  • If you have an allergy to adefovir, any other medications, or any of the ingredients in adefovir tablets, tell your doctor and pharmacist right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Aside from the drugs indicated in the IMPORTANT WARNING section, make sure to include lamivudine (Combivir, Epivir, Epivir-HBV, Epzicom, Triumeq, or Trizivir) or tenofovir (Viread, in Atripla, in Complera, in Stribild, in Truvada). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. While using adefovir, avoid taking any other medications unless your doctor has instructed you to.
  • If you are pregnant or intend to become pregnant, avoid taking adefovir. Call your doctor if you become pregnant while taking adefovir. If you are taking adefovir, stop breastfeeding.
  • Inform your doctor or dentist that you are taking adefovir if you are having surgery, including dental surgery.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Take the missing dose as soon as you remember it if you recollect the missed dose on the day that you were intended to take it. On the other hand, skip the missed dose and carry on with your regular dosing plan if you don’t realise you missed it until the following day. Adefovir should not be used more than once on the same day. Do not take two doses at once.

What side effects can this medication cause?

Adefovir might have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Weakness
  • Headache
  • Diarrhea
  • Gas
  • Indigestion
  • Unwell throat
  • Clogged nose
  • Rash

Adefovir may result in additional adverse effects. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Uneasy stomach
  • Uncomfortable stomach

What other information should I know?

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Hepsera®
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