Crizanlizumab-tmca injection is used to lessen the frequency of pain crises (acute, severe pain that lasts for several hours to days) in adults and children with sickle cell disease who are 16 years of age and older (an inherited blood disease). The drug crizanlizumab-tmca belongs to the monoclonal antibody drug class. By preventing specific blood cells from communicating, it works.

A doctor or nurse will administer the crizanlizumab-tmca injection intravenously (into a vein) over the course of 30 minutes. For the first two doses, it is typically administered once every two weeks, and subsequently once every four weeks.

Within 24 hours of taking a dose, crizanlizumab-tmca injection can result in significant infusion responses. Both during and after the infusion, a doctor or nurse will keep a close eye on you to make sure you are not having a severe reaction to the medication. Inform your doctor or nurse right away if you suffer any of the following symptoms: fever, chills, nausea, vomiting, fatigue, dizziness, sweating, rash, hives, itching, wheezing, or trouble breathing.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before using crizanlizumab-tmca injection,

• If you have an allergy to crizanlizumab-tmca, any other drugs, or any of the ingredients in crizanlizumab-tmca injection, tell your doctor and pharmacist right away. Request a list of the components from your pharmacist.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, or dietary supplements you are currently taking or intend to take. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you get pregnant while taking crizanlizumab-tmca injectable.

Keep eating normally unless your doctor instructs you otherwise.

Call your doctor as soon as you can if you can’t make it to a crizanlizumab-tmca infusion appointment.

The injection of crizanlizumab-tmca may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Nausea
• Joint or back ache
• Fever
• Redness, discomfort, swelling, or burning at the injection site

Other negative effects from crizanlizumab-tmca injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep all of your appointments with your physician and the lab.

Inform the lab staff and your doctor that you are taking crizanlizumab-tmca prior to any laboratory test.

Ask any inquiries you may have regarding crizanlizumab-tmca to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.