Why is this medication prescribed?

Adagrasib is prescribed primarily for the treatment of certain types of cancer. It is a targeted therapy used to treat cancers that have mutations in the KRAS gene, specifically the KRAS G12C mutation. This drug works by inhibiting the mutated KRAS protein, which helps to slow down or stop the growth of cancer cells. It’s commonly used in cases of non-small cell lung cancer (NSCLC) and other cancers where this mutation is present.

How should this medicine be used?

Adagrasib is typically taken orally in the form of tablets. Here are some general guidelines on how it should be used:

• Dosage: The exact dosage and schedule should be determined by your healthcare provider based on your specific condition and response to the drug. It’s usually taken twice a day.
• Administration: Take the tablets at the same times each day, with or without food, as directed by your healthcare provider. Swallow the tablets whole with a glass of water. Do not crush, chew, or break them.
• Missed Dose: If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not double up to make up for a missed dose.
• Interactions: Inform your healthcare provider of all other medications and supplements you are taking, as they may interact with Adagrasib.
• Monitoring: Regular follow-up appointments and tests may be required to monitor your response to the medication and manage any side effects.

Always follow your healthcare provider’s instructions and consult them if you have any questions or concerns about how to take Adagrasib.

Other uses for this medicine

Adagrasib is mainly used for cancers with the KRAS G12C mutation, such as non-small cell lung cancer (NSCLC) and potentially other cancers with this specific mutation. Research is ongoing to explore its effectiveness in other types of cancer or settings.

What special precautions should I follow?

Special Precautions for Adagrasib:

• Allergies and Reactions: Inform your healthcare provider if you have any known allergies to Adagrasib or other medications.
• Medical History: Disclose your complete medical history, especially if you have liver problems, kidney issues, or any other significant health conditions.
• Drug Interactions: Be cautious about potential drug interactions. Inform your doctor about all medications, including over-the-counter drugs, vitamins, and herbal supplements you are taking.
• Pregnancy and Breastfeeding: Adagrasib may harm an unborn baby. Use effective contraception to prevent pregnancy while on this medication. It is not known if Adagrasib passes into breast milk, so discuss with your doctor whether you should avoid breastfeeding during treatment.
• Side Effects: Monitor for any side effects such as nausea, diarrhea, liver problems, or other unusual symptoms. Report these to your healthcare provider promptly.
• Regular Testing: Adagrasib may require regular blood tests and other evaluations to monitor its effects and detect any potential side effects.
• Avoid Grapefruit: Grapefruit and grapefruit juice may interact with Adagrasib, potentially affecting how the drug works. Avoid consuming them unless directed otherwise by your healthcare provider.

Always follow your healthcare provider’s guidance for safe and effective use of Adagrasib.

What special dietary instructions should I follow?

• Food Intake: Adagrasib can be taken with or without food. However, consistency is important, so try to take it the same way each time, either always with food or always without.
• Grapefruit and Grapefruit Juice: Avoid consuming grapefruit and grapefruit juice, as they may interfere with how Adagrasib works in your body.
• Hydration: Maintain adequate hydration, as some side effects may be mitigated by drinking plenty of fluids.

What should I do if I forget a dose?

• Timing: If you miss a dose, take it as soon as you remember, unless it’s close to the time of your next scheduled dose.
• Do Not Double Up: Do not take two doses at once to make up for a missed dose. This could increase the risk of side effects.
• Contact Healthcare Provider: If you’re unsure about what to do after missing a dose, or if you have missed several doses, contact your healthcare provider for specific guidance.

What side effects can this medication cause?

Adagrasib can cause a range of side effects, some of which may be more common or severe than others. Here are some potential side effects:

Common Side Effects:

• Nausea: Feeling sick to your stomach.
• Diarrhea: Frequent, loose bowel movements.
• Fatigue: Feeling unusually tired or weak.
• Loss of Appetite: Reduced desire to eat.
• Vomiting: Throwing up.
• Skin Rash: Rash or other skin changes.

Less Common but Serious Side Effects:

• Liver Problems: Elevated liver enzymes or jaundice (yellowing of the skin/eyes). Symptoms may include dark urine, persistent nausea, or abdominal pain.
• Lung Issues: Difficulty breathing or persistent cough.
• Heart Problems: Symptoms such as chest pain or swelling in the legs and ankles.
• Kidney Problems: Changes in urination patterns or swelling.
• Infections: Increased risk of infections, possibly due to a weakened immune system.
• Allergic Reactions: Symptoms may include rash, itching, swelling, severe dizziness, or trouble breathing.
• Severe Gastrointestinal Issues: Severe or persistent diarrhea that could lead to dehydration.

It’s important to report any unusual or severe side effects to your healthcare provider promptly. They can offer guidance on managing these effects and decide if any adjustments to your treatment are necessary. Regular monitoring and communication with your healthcare team are key to managing side effects effectively.

What should I know about storage and disposal of this medication?

Storage and Disposal of Adagrasib:

• Storage:
  • Temperature: Store Adagrasib at room temperature, typically between 68°F to 77°F (20°C to 25°C).
  • Protection: Keep the medication in its original container, tightly closed, and away from moisture and direct sunlight.
  • Children and Pets: Keep Adagrasib out of reach of children and pets to prevent accidental ingestion.
• Disposal:
  • Unused Medication: Do not flush Adagrasib down the toilet or pour it into a drain unless instructed by a disposal program.
  • Drug Take-Back Programs: Use a drug take-back program or follow local guidelines for safe disposal of unused or expired medications.
  • Household Disposal: If no take-back program is available, mix Adagrasib with an undesirable substance (like coffee grounds or cat litter), place it in a sealed container, and dispose of it in the household trash. Check with local waste disposal authorities for specific instructions.

In case of emergency/overdose

• Symptoms of Overdose: Symptoms of an overdose might include severe nausea, vomiting, diarrhea, or liver problems.
• Contact Poison Control: Call your local poison control center or emergency services immediately if you suspect an overdose.
• Emergency Room: Seek immediate medical attention at an emergency room if advised by poison control or if you experience severe symptoms.
• Information to Provide: Provide details about the amount of Adagrasib taken, the time it was taken, and any symptoms you’re experiencing to medical professionals.

What other information should I know?

• Regular Monitoring: Regular follow-up visits with your healthcare provider are important to monitor the effectiveness of the medication and manage any side effects.
• Drug Interactions: Be aware of potential interactions with other drugs or supplements you are taking. Always inform your healthcare provider about all medications and supplements.
• Adherence: Take Adagrasib exactly as prescribed, and do not stop or adjust the dose without consulting your healthcare provider.
• Support and Resources: Reach out to support groups or counseling if you need emotional or psychological support during your treatment.

Always follow your healthcare provider’s guidance for the best outcomes while using Adagrasib.