WARNING

Taking Actiq (generic fentanyl) carries several risks:

• Overdose: Actiq is highly potent, and taking too much can lead to severe respiratory depression, which can be fatal.
• Respiratory Issues: It can cause slow or difficult breathing, particularly in those with existing respiratory conditions.
• Addiction and Dependence: Long-term use can lead to physical dependence and addiction, especially if not used as prescribed.
• Side Effects: Common side effects include drowsiness, nausea, constipation, and dry mouth. Serious side effects can include severe allergic reactions and extreme sedation.
• Interactions: It can interact dangerously with other medications and substances, increasing the risk of adverse effects.
• Misuse Potential: Actiq has a high potential for misuse due to its potent effects, which can be especially risky if used by individuals who are not already tolerant to opioids.

Always use Actiq exactly as prescribed by a healthcare provider and be aware of the risks associated with its use.

Why is this medication prescribed?

Actiq, which is a brand name for fentanyl in the form of a lozenge on a stick, is prescribed primarily for managing breakthrough pain in cancer patients who are already receiving and tolerant to other opioid medications. Breakthrough pain is a sudden and intense episode of pain that “breaks through” the baseline pain control provided by other medications.

Actiq is a potent opioid, and it works quickly to provide relief because it’s absorbed through the mucous membranes in the mouth. Its use is generally limited to individuals with cancer-related pain who have developed a tolerance to other opioids, due to the risks of addiction and side effects associated with fentanyl.

How should this medicine be used?

Actiq should be used according to the specific instructions provided by a healthcare professional. Here are some general guidelines for its use:

• Administration: Place the Actiq lozenge on the stick between your cheek and gum. Allow it to dissolve slowly. Do not chew, bite, or swallow the lozenge. This helps ensure the medication is absorbed effectively through the mucous membranes in the mouth.
• Dosage: Use the lozenge only as prescribed. Your doctor will determine the appropriate dose based on your pain levels and opioid tolerance. It’s crucial to follow the prescribed dosage to avoid overdose or side effects.
• Timing: Actiq is typically used for breakthrough pain episodes. You should only use it when you experience this type of pain, not on a regular schedule.
• Storage: Keep Actiq in its original container and store it at room temperature. Keep it out of reach of children and pets, as fentanyl can be very dangerous if ingested by someone not prescribed the medication.
• Safety: Avoid consuming alcohol or other central nervous system depressants while using Actiq. Be cautious of activities that require full attention, like driving, as the medication can impair your ability to perform these tasks safely.

Always follow your healthcare provider’s instructions and consult them if you have any questions or concerns about using Actiq.

Other uses for this medicine

Actiq is primarily prescribed for breakthrough pain in cancer patients, but it can also be used in other situations where short-term, rapid pain relief is needed for individuals who are already tolerant to opioid medications. However, due to its potency, it is generally not prescribed for other types of pain or for use in people who are not already receiving opioid treatment.

What special precautions should I follow?

Special Precautions for Actiq:

• Opioid Tolerance: Actiq should only be used by individuals who are already tolerant to other opioids. It is not intended for use in opioid-naive patients due to the risk of overdose.
• Overdose Risk: Fentanyl is a highly potent opioid, and using too much can lead to serious, potentially fatal respiratory depression. Always adhere to the prescribed dose and avoid using more than directed.
• Avoid Misuse: Keep Actiq out of reach of children and others who might misuse it. Misuse of fentanyl can result in overdose and death.
• Interactions: Be cautious about drug interactions. Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs and herbal supplements, as they can interact with Actiq and increase the risk of adverse effects.
• Driving and Operating Machinery: Actiq can impair your ability to perform tasks that require full attention and coordination. Avoid driving or operating heavy machinery if you feel drowsy or impaired.
• Respiratory Conditions: If you have a history of respiratory issues, such as asthma or chronic obstructive pulmonary disease (COPD), inform your doctor, as Actiq can exacerbate these conditions.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Opioids can affect the fetus and nursing infant, and your doctor will weigh the benefits and risks before prescribing Actiq.
• Withdrawal Symptoms: If you need to stop using Actiq, your healthcare provider will provide guidance on how to taper off the medication to avoid withdrawal symptoms.

Always follow the guidance of your healthcare provider when using Actiq and discuss any concerns or side effects you experience.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions associated with Actiq. However, you should avoid alcohol and other central nervous system depressants as they can increase the risk of severe side effects. Always follow your healthcare provider’s advice regarding alcohol and other substances while taking Actiq.

What should I do if I forget a dose?

Actiq is typically used on an as-needed basis for breakthrough pain, so missing a dose might not be a significant concern. If you miss a dose and still experience breakthrough pain, follow the dosing schedule provided by your healthcare provider or contact them for guidance. Never take a double dose to make up for a missed dose.

What side effects can this medication cause?

Actiq (fentanyl) can cause a range of side effects, some of which can be serious. Here are potential side effects to be aware of:

Common Side Effects:

• Drowsiness: You might feel unusually sleepy or fatigued.
• Nausea and Vomiting: Gastrointestinal upset can occur.
• Constipation: Opioids often slow down the digestive system.
• Dry Mouth: This can be a common effect due to the lozenge form of the medication.
• Headache: Some people experience headaches.

Serious Side Effects:

• Respiratory Depression: Slowed or difficult breathing is a serious side effect that can be life-threatening. Seek immediate medical attention if you experience this.
• Overdose: Symptoms include severe drowsiness, slow or difficult breathing, or loss of consciousness. This is a medical emergency.
• Severe Allergic Reactions: Symptoms might include rash, itching, swelling, severe dizziness, or trouble breathing. Immediate medical attention is required.
• Confusion or Hallucinations: Severe changes in mood or perception can occur.
• Low Blood Pressure: Symptoms might include dizziness, lightheadedness, or fainting.

Less Common but Serious Side Effects:

• Urinary Retention: Difficulty urinating or reduced urine output.
• Severe Constipation: Leading to abdominal pain, nausea, or vomiting.

If you experience any severe or persistent side effects, contact your healthcare provider immediately. For less severe side effects, report them to your provider to determine if any adjustments to your treatment are needed. Always use Actiq as prescribed and consult your healthcare provider with any concerns.

What should I know about storage and disposal of this medication?

Storage and Disposal of Actiq:

• Storage:
  • Keep it Secure: Store Actiq in its original container, tightly closed, and out of reach of children and pets.
  • Temperature: Store at room temperature, away from excess heat and moisture. Avoid storing in bathrooms.
  • Avoid Sharing: Do not share Actiq with others, even if they have similar symptoms. This can be dangerous and is against the law.
• Disposal:
  • Medication Take-Back Programs: The best way to dispose of Actiq is to take it to a medication take-back program or a drug disposal kiosk. Many pharmacies and local government programs offer these services.
  • Dispose in Household Trash: If a take-back program is not available, follow specific disposal instructions provided with the medication. Usually, you can mix the medication with an undesirable substance (like used coffee grounds) and place it in a sealed plastic bag before disposing of it in the household trash. Check the medication’s label or contact your pharmacist for any specific disposal instructions.

In case of emergency/overdose

• • Call Emergency Services: Contact emergency services immediately if you suspect an overdose.
  • Administer Naloxone: If available, administer naloxone (Narcan) as it can counteract the effects of opioid overdose. Follow the instructions provided with the naloxone.
  • Do Not Wait: Overdose can be life-threatening, so do not wait for symptoms to worsen. Seek medical help right away.
  • Signs of Overdose:
    • Severe drowsiness
    • Slow or difficult breathing
    • Loss of consciousness

What other information should I know?

• Drug Interactions: Inform your healthcare provider of all medications you are taking, including over-the-counter drugs, herbal supplements, and other opioids, to avoid dangerous interactions.
• Regular Check-Ins: Schedule regular follow-ups with your healthcare provider to monitor your condition and adjust your medication as needed.
• Personal Health History: Provide your doctor with a complete medical history, including any history of substance abuse, mental health conditions, or respiratory issues.
• Emergency Contact: Have an emergency contact or plan in place in case of adverse reactions or other issues.

Always follow the guidance provided by your healthcare provider and the instructions that come with Actiq. If you have any questions or concerns, don’t hesitate to reach out to your healthcare provider or pharmacist.