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Acticlate (Generic Doxycycline)

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Why is this medication prescribed?

Doxycycline is used to treat a range of infections brought on by particular bacterial strains. In addition, doxycycline is used to treat or prevent plague and tuleramia, as well as anthrax (a dangerous infection that can be intentionally spread as part of a bioterror strike) (serious infections that may be spread on purpose as part of a bioterror attack). Malaria is also avoided by using it. Along with other drugs, doxycycline is also used to treat rosacea and acne (a skin disease that causes redness, flushing, and pimples on the face). Only rosacea-related bumps and pimples can be treated with doxycycline (Oracea). Tetracycline antibiotics, which include doxycycline, are a group of drugs. By limiting bacterial growth and spread, it helps to treat infections. By eliminating the bacteria that causes pore infections and reducing a certain natural greasy component that causes acne, it effectively treats acne. By reducing the inflammation that leads to this illness, it helps treat rosacea.

Colds, the flu, or any other viral infections will not be treated by antibiotics like doxycycline. Antibiotic overuse raises the likelihood that you’ll get an infection later on that is resistant to antibiotic therapy.

How should this medicine be used?

Doxycycline is available as a liquid suspension, tablet, delayed-release tablet, and capsule for oral consumption. One or two doses of doxycycline are typically taken each day. Each dose should be followed by a full glass of water. If taking doxycycline causes stomach distress, you can take it with food or milk. Obtain advice from your physician or pharmacist regarding the ideal doxycycline dosage. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Take doxycycline as prescribed by your doctor. Never take it in larger or less amounts or more frequently than directed by your doctor.

Do not split, chew, or crush the delayed-release pills; instead, swallow them whole.

The contents of some delayed-release tablets (Doryx; generics) can be sprinkled on a spoonful of cold or room temperature (not hot) applesauce if you are unable to swallow them whole. While you are breaking apart the tablet, take care not to harm or crush any of the pellets. Immediately consume the concoction and swallow it without chewing. The combination should be thrown away if it cannot be consumed straight away.

Before each use, thoroughly shake the suspension to combine the medication.

Start taking doxycycline 1–2 days prior to travel to a malaria-endemic area if you’re taking it to avoid malaria. Every day you are there and for four weeks after you leave, keep taking doxycycline. Doxycycline shouldn’t be taken for more than four months in order to prevent malaria.

Even if you feel well, keep taking doxycycline. Unless your doctor instructs you otherwise, take the medication completely until you have finished it.

It might not be possible to switch out one doxycycline product for another. Make sure you only take the brand of doxycycline that your doctor has recommended. If you have any inquiries concerning the brand of doxycycline you were prescribed, speak with your pharmacist.

Other uses for this medicine

The drug doxycycline can also be used to treat malaria. For certain people who have been bitten by a tick, it may also be used to treat or prevent Lyme disease. Additionally, it can be used to persons who have experienced sexual assault to stop infection. Discuss the potential dangers of using this medicine for your illness with your doctor.

Ask your doctor or pharmacist for more details if you’re interested in using this drug for any other conditions.

What special precautions should I follow?

Before taking doxycycline,

  • If you have any allergies to doxycycline, minocycline (Dynacin, Minocin, Solodyn, Ximino), tetracycline (Achromycin V, in Pylera), demeclocycline, other medicines, sulfites, or any of the components in doxycycline capsules, tablets, extended-release tablets, or suspension, let your doctor and pharmacist know right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any prescription and over-the-counter drugs, vitamins, and dietary supplements you are currently taking or intend to take. Incorporate any of the following: acitretin, warfarin (Jantoven), bismuth subsalicylate, carbamazepine (Epitol, Tegretol, other brands), isotretinoin (Absorica, Clavaris, Myorisan, Zenatane), and anticoagulants (sometimes known as “blood thinners”). Proton pump inhibitors such dexlansoprazole (Dexilant), esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid, in Talicia), pantoprazole (Protonix), and rabeprazole (Phenytoin, Phenytek), as well as penicillin, phenobarbital, phen (Aciphex). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Be advised that doxycycline is interfered with and rendered less effective by items containing magnesium, aluminium, or calcium, calcium supplements, iron products, and laxatives. Doxycycline should be taken one to two hours before or after taking antacids, calcium supplements, and magnesium-containing laxatives. Take doxycycline two hours before or three hours after taking iron supplements or iron-containing vitamins.
  • Inform your doctor if you have or have ever had lupus (a condition in which the immune system attacks numerous tissues and organs, including the skin, joints, blood, and kidneys), intracranial hypertension (pseudotumor cerebri; high pressure in the skull that may cause headaches, double vision, vision loss, and other symptoms), a yeast infection in your mouth or vagina, stomach surgery, asthma, kidney disease, or any other of these conditions. If you develop diarrhoea, let your doctor know as well.
  • You should be aware that doxycycline might lessen how well hormonal contraceptives work (birth control pills, patches, rings, or injections). Consult your doctor before adopting a different method of birth control.
  • If you are pregnant or want to become pregnant, let your doctor know. Call your doctor right away if you become pregnant while taking doxycycline. The foetus could be harmed by doxycycline.
  • Inform your doctor if you are nursing a child. You might be advised by your doctor to stop breastfeeding while taking doxycycline.
  • Make a plan to limit your time spent in the sun and to use sunscreen, sunglasses, and protective clothes. Your skin could become photosensitive if you use doxycycline. If you have a sunburn, tell your doctor as soon as possible.
  • You should be aware that in addition to using precautionary measures like efficient insect repellent, mosquito nets, clothing that covers your entire body, and staying in well-screened locations, especially from dusk till dawn, when taking doxycycline to prevent malaria. Doxycycline does not completely protect you from malaria.
  • You should be aware that doxycycline might cause teeth to become permanently discoloured and can interfere with bone formation when used during pregnancy, in newborns, or in children under the age of eight. Except in cases of inhalational anthrax, Rocky Mountain spotted fever, or if your doctor deems it necessary, doxycycline shouldn’t be administered to kids younger than 8 years old.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Doxycycline could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Diarrhea
  • Reduced appetite
  • The rectum itches
  • Vaginal enlargement, redness, stinging, itching, or irritation
  • Virulent discharge
  • Difficult or painful urinating
  • Sore nose or throat
  • Enlarged tongue
  • Mouth ache
  • Anxiety
  • Back ache
  • Skin, scars, nails, eyes, or mouth colour changes

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • Headache
  • Vision loss, double vision, or blurry vision
  • Perhaps feverish or gland-swelling rash
  • Hives
  • Scorching, peeling, or ruddy skin
  • Breathing or swallowing challenges
  • Swelling of the lips, tongue, throat, eyes, or face
  • Uncommon bruising or bleeding
  • During therapy or for up to two or more months after quitting it, you may experience fever, sore throat, chills, or other
  • Infection-related symptoms such as bloody or watery stools, stomach cramps, or fever
  • Aching joints
  • Teeth that are permanent (adult) and discoloured


Other negative effects of doxycycline are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from light, excessive heat, and moisture at room temperature (not in the bathroom).

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. Your physician will want to assess how you are reacting to doxycycline.

Inform the lab staff and your doctor that you are taking doxycycline prior to any laboratory test.

No one else should take your medication. It’s likely that your prescription cannot be renewed. Call your doctor if you continue to experience infection symptoms after finishing the doxycycline.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Acticlate®
  • Acticlate CAP®
  • Doryx®
  • Doryx MPC®
  • Doxychel®
  • Monodox®
  • Oracea®
  • Periostat®
  • Vibra-Tabs®
  • Vibramycin®
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