Why is this medication prescribed?

Acthar Gel, or corticotropin, is a medication used to treat a variety of conditions, primarily by influencing the adrenal glands and their hormone production. It is often prescribed for:

• Multiple Sclerosis (MS): To manage acute exacerbations.
• Rheumatic Disorders: For conditions like rheumatoid arthritis or systemic lupus erythematosus.
• Infantile Spasms: A type of epilepsy in infants.
• Skin Conditions: Such as psoriasis and eczema.
• Certain Endocrine Disorders: Like adrenal insufficiency or Addison’s disease.

Acthar Gel works by stimulating the adrenal glands to produce more cortisol, a hormone that helps reduce inflammation and regulate various bodily functions. It’s usually considered when other treatments are not effective or appropriate.

How should this medicine be used?

Acthar Gel, also known as adrenocorticotropic hormone (ACTH), is used primarily for its anti-inflammatory and immunosuppressive effects. It’s often prescribed for conditions like multiple sclerosis, certain types of arthritis, and other inflammatory or autoimmune disorders.

Here’s a general overview of how it’s used:

• Administration: Acthar Gel is typically administered via intramuscular injection. It’s usually injected into the muscle of the upper arm, thigh, or buttock. The injections are generally given by a healthcare provider, though in some cases, patients might be trained to administer it themselves.
• Dosage: The dosage and frequency of Acthar Gel can vary depending on the condition being treated. Your doctor will determine the appropriate dose based on your specific situation. It’s important to follow the prescribed dosage and schedule closely.
• Preparation: Before administering, the gel should be inspected for any particulate matter or discoloration. It should be gently mixed, not shaken, to ensure uniformity.
• Side Effects: Be aware of potential side effects, which can include weight gain, fluid retention, high blood pressure, mood changes, and more. Long-term use can lead to additional side effects like osteoporosis or increased risk of infection.
• Monitoring: Regular follow-up appointments with your healthcare provider are important to monitor your response to the medication and adjust the dosage if needed.

Always follow the specific instructions provided by your healthcare provider or the medication’s prescribing information. If you have any questions or concerns about using Acthar Gel, it’s best to discuss them with your healthcare provider.

Other uses for this medicine

• Infantile Spasms: Acthar Gel is sometimes used to treat infantile spasms, a type of seizure seen in young children.
• Nephrotic Syndrome: It may be used for certain types of nephrotic syndrome, a kidney disorder that causes the body to excrete too much protein in the urine.
• Certain Types of Allergies: In some cases, it may be used for severe allergic reactions or conditions where inflammation is a major factor.

What special precautions should I follow?

Special Precautions to Follow:

• Medical History: Inform your healthcare provider of any history of infections, high blood pressure, diabetes, kidney problems, or any other significant medical conditions.
• Infections: Acthar Gel can suppress the immune system, making you more susceptible to infections. Avoid contact with people who have contagious diseases.
• Vaccinations: Live vaccines should generally be avoided while on Acthar Gel. Check with your healthcare provider about any vaccinations you may need.
• Bone Health: Long-term use can lead to bone thinning. Your doctor might monitor bone density and recommend lifestyle changes or medications to protect bone health.
• Blood Sugar Levels: It can affect blood sugar levels, so if you have diabetes or are at risk of diabetes, regular monitoring may be necessary.
• Mood Changes: Watch for mood swings or behavioral changes and report them to your doctor. Corticosteroids can affect mood and mental health.
• Pregnancy and Breastfeeding: Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Acthar Gel can have effects on both.

Always follow your doctor’s instructions and discuss any concerns or side effects you experience while using Acthar Gel.

What special dietary instructions should I follow?

• Sodium Intake: Acthar Gel can cause fluid retention and high blood pressure, so it may be helpful to reduce sodium (salt) intake to manage these effects.
• Calcium and Vitamin D: Since long-term use can impact bone health, ensure adequate intake of calcium and vitamin D through your diet or supplements as recommended by your healthcare provider.
• Balanced Diet: Maintain a balanced diet to support overall health and help manage any side effects related to weight gain or changes in metabolism.

What should I do if I forget a dose?

• Timing: If you miss a dose, contact your healthcare provider for specific instructions. They will advise you based on how much time has passed since the missed dose.
• Do Not Double Dose: Do not take a double dose to make up for a missed one, as this can increase the risk of side effects.
• Regular Schedule: Try to take Acthar Gel at the same time each day to help remember your doses and maintain consistent levels in your system.

What side effects can this medication cause?

Acthar Gel can cause a range of side effects, some of which may vary depending on the individual and the duration of use. Here are some common and serious side effects:

Common Side Effects:

• Weight Gain: Fluid retention and increased appetite can lead to weight gain.
• Mood Changes: Anxiety, mood swings, or depression may occur.
• Increased Blood Pressure: You might experience elevated blood pressure.
• Fluid Retention: Swelling in your hands, feet, or ankles can happen.
• Insomnia: Difficulty sleeping or insomnia may be reported.
• Digestive Issues: Nausea, vomiting, or stomach upset can occur.

Serious Side Effects:

• Infections: Increased susceptibility to infections due to immune system suppression.
• Osteoporosis: Long-term use can lead to bone thinning and an increased risk of fractures.
• High Blood Sugar: Risk of developing diabetes or worsening existing diabetes due to increased blood sugar levels.
• Psychiatric Effects: Severe mood changes, depression, or psychosis in some cases.
• Eye Issues: Possible development of cataracts or glaucoma.
• Muscle Weakness: Prolonged use can cause muscle weakness or wasting.
• Adrenal Insufficiency: Abrupt discontinuation may lead to adrenal insufficiency or withdrawal symptoms.

Less Common but Serious Effects:

• Gastrointestinal Bleeding: Rarely, it may cause bleeding or ulcers in the stomach or intestines.
• Heart Problems: Risk of heart failure or other cardiovascular issues in susceptible individuals.

If you experience any severe or persistent side effects, contact your healthcare provider immediately. They can provide guidance on managing side effects or adjust your treatment if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Acthar Gel:

• Storage:
  • Temperature: Store Acthar Gel in the refrigerator at 36°F to 46°F (2°C to 8°C). Do not freeze it.
  • Protection from Light: Keep it in its original container to protect it from light.
  • Accessibility: Keep it out of reach of children and pets.
• Disposal:
  • Expired or Unused: Dispose of expired or unused Acthar Gel according to your local regulations. Some communities have drug take-back programs or designated disposal sites.
  • Do Not Flush: Do not flush the medication down the toilet or pour it into a drain unless instructed to do so by your local waste disposal authorities.

In case of emergency/overdose

• • Contact Healthcare Provider: If you experience severe side effects or symptoms of an allergic reaction (such as rash, itching, swelling, severe dizziness, or trouble breathing), seek immediate medical attention.
  • Call Emergency Services: If you believe it’s a life-threatening emergency, call emergency services or go to the nearest emergency room.
  • Symptoms: Symptoms of an overdose may include severe mood changes, muscle weakness, or significant weight gain.
  • Seek Medical Help: Contact your healthcare provider or go to the emergency room if you suspect an overdose. They can provide the appropriate treatment based on your symptoms.

What other information should I know?

• Regular Monitoring: Regular follow-up with your healthcare provider is important to monitor the effects of Acthar Gel and adjust the dosage if needed.
• Drug Interactions: Inform your doctor about all other medications you are taking, including over-the-counter drugs and supplements, as Acthar Gel can interact with other medications.
• Patient Information Leaflet: Read and understand the patient information leaflet that comes with Acthar Gel for detailed instructions on use, side effects, and other important information.
• Keep Records: Maintain a record of your doses and any side effects you experience to discuss with your healthcare provider during appointments.

Always follow your healthcare provider’s instructions for using, storing, and disposing of Acthar Gel, and consult them if you have any questions or concerns.