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Acetoxymethylprogesterone (Generic Medroxyprogesterone)

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Why is this medication prescribed?

Medroxyprogesterone is used to treat irregular vaginal bleeding or abnormal menstruation (periods). Medroxyprogesterone can also be used to start a normal menstrual cycle in women who previously had one but have not had one in at least six months, are not pregnant, or are not going through menopause (change of life). In patients taking oestrogen, medroxyprogesterone is also used to prevent the uterine lining from growing too much and may lower the risk of uterine cancer. Progestins are a class of drugs that includes medroxyprogesterone. It functions by inducing the uterus to produce specific hormones and halting the formation of the uterine lining.

How should this medicine be used?

Medroxyprogesterone is available as an oral tablet. On specific days throughout a typical monthly cycle, it is typically taken once each day. Medroxyprogesterone should be taken on the days you are supposed to take it at roughly the same time each day to help you remember to take it. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow the prescription for medroxyprogesterone precisely. Never take it in larger or less amounts or more frequently than directed by your doctor.

Your problem may be controlled but not cured with medroxyprogesterone. Even if you feel good, keep taking medroxyprogesterone as directed on a monthly basis. Without consulting your doctor, do not discontinue taking medroxyprogesterone.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking medroxyprogesterone,

  • If you have any drug allergies, including those to maize, medroxyprogesterone (Provera, Depo-Provera), or any other substances, tell your doctor right away.
  • Inform your physician and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are taking. Mention aminoglutethimide if you can (Cytadren). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have or have ever had breast cancer, cancer of the uterus, cancer of the reproductive system, unexplained vaginal bleeding, missed abortion (pregnancy that ended when the foetus died in the uterus but was not expelled from the body), blood clots in your legs, lungs, brain, or eyes, stroke or mini-stroke, seizures, migraine headaches, depression, asthma, diabetes, heart, kidney, or liver disease.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor right away if you get pregnant while taking medroxyprogesterone. During the first few months of pregnancy, medroxyprogesterone should never be used to detect pregnancy or to stop miscarriage. The foetus could be harmed by medroxyprogesterone, which has not been proven to stop miscarriages.
  • Inform the surgeon or dentist that you are taking medroxyprogesterone if you are having surgery, including dental surgery.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Side effects from medroxyprogesterone are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Sensitive breasts that bleed or secrete liquid
  • Modifications to menstrual flow
  • Abnormal spotting or bleeding in the vagina
  • Acne
  • Facial hair growth
  • Hair loss on the scalp
  • Having trouble falling or staying asleep
  • Drowsiness
  • Uneasy stomach
  • Loss or increase of weight

Some adverse effects can be very harmful. Even though the following signs are unusual, you should call your doctor right once if you notice any of them:

  • One leg only may experience pain, swell, warmth, redness, or discomfort.
  • Slow or challenging speech
  • Unsteadiness or weakness
  • Arm or leg weakness or numbness
  • Breathing difficulty
  • Exhaling blood
  • Crushing or sudden chest discomfort
  • A hammering or rapid heartbeat
  • Vision loss or sudden changes in vision
  • Dual perception
  • Distorted vision
  • Enlarged eyes
  • Missed cycles
  • Depression
  • The skin or eyes turning yellow
  • Fever
  • Hives
  • Itching
  • Skin rash
  • Breathing or swallowing challenges
  • Hands, foot, ankles, or lower legs swelling

When fed medroxyprogesterone, several laboratory animals developed breast cancers. It is unknown if medroxyprogesterone makes people more susceptible to developing breast cancer. Additionally, medroxyprogesterone may raise your risk of developing a blood clot that travels to your lungs or brain. The dangers of using this drug should be discussed with your doctor.

Other negative consequences of medroxyprogesterone are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all appointments with your doctor.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking medroxyprogesterone.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Amen®
  • Curretab®
  • Cycrin®
  • Prodroxy®
  • Provera®
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