Why is this medication prescribed?

Adstiladrin (also known as nadofaragene firadenovec) is prescribed for patients with certain types of bladder cancer. It is a type of gene therapy used to treat high-risk, non-muscle invasive bladder cancer (NMIBC) that has not responded well to other treatments. Adstiladrin works by delivering a gene that produces a protein designed to help the immune system target and destroy cancer cells in the bladder. It’s usually given as an intravesical therapy, meaning it’s administered directly into the bladder through a catheter.

How should this medicine be used?

Adstiladrin is administered intravesically, meaning it’s delivered directly into the bladder through a catheter. Here’s a general overview of the process:

• Preparation: The patient is usually asked to empty their bladder before the procedure.
• Catheter Insertion: A catheter is inserted into the bladder through the urethra.
• Administration: Adstiladrin is then introduced into the bladder through the catheter.
• Retention: The patient will need to hold the medication in the bladder for a specified period (usually about 1 to 2 hours) to allow it to work effectively.
• Removal: After the retention period, the catheter is removed, and the patient can empty their bladder.

The exact details and schedule of the treatment may vary based on the patient’s condition and the healthcare provider’s recommendations. It’s important to follow the specific instructions given by the healthcare team for the best results.

Other uses for this medicine

Adstiladrin is specifically designed for treating high-risk, non-muscle invasive bladder cancer. Its use is generally confined to this indication due to its targeted action and the nature of its delivery method.

What special precautions should I follow?

Special Precautions:

• Bladder Health: Since Adstiladrin is administered directly into the bladder, it’s important to ensure there are no active infections or severe irritation in the bladder before starting treatment.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, you should inform your healthcare provider. Adstiladrin is not typically recommended during pregnancy or breastfeeding due to potential risks.
• Infection Prevention: Before and during treatment, you should be monitored for signs of urinary tract infections (UTIs) or other infections. Maintaining good personal hygiene and following your provider’s advice can help minimize infection risks.
• Hydration: Staying well-hydrated is important, but you should follow specific instructions about fluid intake around the time of treatment, as excessive or insufficient fluid intake might affect treatment.
• Follow-Up Care: Regular follow-up appointments and monitoring are essential to assess the effectiveness of the treatment and to watch for any side effects or complications.

Always consult your healthcare provider for personalized advice and to address any specific concerns you might have.

What special dietary instructions should I follow?

There are typically no specific dietary restrictions associated with Adstiladrin. However, it’s a good idea to:

• Stay Hydrated: Drink plenty of fluids, but follow any specific recommendations your healthcare provider gives about fluid intake around the time of treatment.
• Avoid Irritants: It might be helpful to avoid irritants such as caffeine, alcohol, and spicy foods that could exacerbate bladder irritation or discomfort.

What should I do if I forget a dose?

If you forget a dose of Adstiladrin:

• Contact Your Healthcare Provider: Inform your healthcare provider or clinic as soon as possible for guidance on how to proceed.
• Follow Instructions: Your healthcare provider will give you specific instructions, which may include rescheduling your dose or continuing with your next scheduled treatment.

What side effects can this medication cause?

Adstiladrin, like any medication, can cause side effects. Some of the common and potential side effects include:

Common Side Effects:

• Bladder Irritation: This can include symptoms like burning sensation, pain, or discomfort while urinating.
• Increased Urinary Frequency: You might feel the need to urinate more often.
• Urgency: A strong, often sudden, need to urinate.
• Hematuria: Blood in the urine, which might cause it to appear pink or red.
• Urinary Tract Infection (UTI): Symptoms can include burning sensation, frequent urination, or cloudy and foul-smelling urine.

Less Common or Severe Side Effects:

• Bladder Pain: Persistent or severe pain in the bladder area.
• Persistent Bleeding: Continued blood in the urine or abnormal bleeding.
• Severe Urinary Tract Symptoms: Such as severe pain, significant blood in urine, or fever, which could indicate a serious infection.
• Allergic Reactions: Though rare, some people might experience allergic reactions, including rash, itching, or swelling.

It’s important to report any new or worsening symptoms to your healthcare provider promptly. They can provide guidance on managing side effects and determine if any adjustments to your treatment are needed.

What should I know about storage and disposal of this medication?

Storage and Disposal of Adstiladrin:

Storage:

• Temperature: Adstiladrin should be stored according to the instructions provided by your healthcare provider or the medication’s packaging. It typically requires refrigeration.
• Protection from Light: Keep the medication away from light and moisture.
• Location: Store it in a secure place, out of reach of children and pets.

Disposal:

• Unused or Expired Medication: Follow specific disposal instructions provided by your healthcare provider or pharmacist. Do not dispose of medications in household trash or down the sink unless directed to do so.
• Medication Take-Back Programs: Consider using medication take-back programs or disposal sites available in your community.

In case of emergency/overdose

• Adrenaclick is an epinephrine auto-injector used for treating severe allergic reactions. If an overdose is suspected or if you experience severe symptoms, take these steps:
• Call emergency services (911) or go to the nearest emergency room right away.
• Let them know if you used Adrenaclick or any other medications.

Signs of an Overdose:

• Severe Headache
• Rapid Heartbeat
• Dizziness
• Tremors
• Paleness or Sweating

What other information should I know?

• Patient Information: Always follow the instructions provided with your medication and consult with your healthcare provider about any concerns or questions.
• Interactions: Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.
• Monitoring: Regular follow-up appointments with your healthcare provider are important to monitor the effectiveness of your treatment and manage any side effects.
• Emergency Plan: If you have a serious condition like severe allergies, make sure to have an action plan and communicate it with those around you (family, friends, or coworkers).

For any specific concerns or additional guidance, always reach out to your healthcare provider or pharmacist.