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Abraxane (Generic Paclitaxel (with albumin) Injection)

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When you receive paclitaxel (with albumin) injections, it’s possible that your blood’s level of white blood cells, which are essential for fighting infection, would significantly drop. Your chance of getting a serious infection rises as a result. If your level of white blood cells is already low, you shouldn’t receive paclitaxel (with albumin). Before and during your therapy, your doctor will request laboratory tests to determine the quantity of white blood cells in your blood. If your white blood cell count is too low, your doctor will postpone or stop your treatment. If you have any of the following during your paclitaxel injection treatment: a temperature higher than 100.4 °F (38 °C), a sore throat, cough, chills, difficult, frequent, or painful urination, or any indicators of infection.

Keep all of your appointments with your physician and the lab. Your doctor will prescribe specific tests to see how your body reacts to the injection of paclitaxel (with albumin).

Discuss the dangers of obtaining an injection of paclitaxel (with albumin) with your doctor.

Why is this medication prescribed?

Breast cancer that has spread to other body areas and has not improved or gotten worse after treatment with other drugs is treated with paclitaxel (with albumin) injection. Non-small cell lung cancer is also treated with paclitaxel (with albumin) injection in conjunction with other chemotherapy drugs (NSCLC). Gemcitabine (Gemzar) and paclitaxel (with albumin) injection are both used to treat pancreatic cancer. The drug paclitaxel belongs to the group of drugs known as antimicrotubule agents. It functions by preventing the development and spread of cancer cells.

How should this medicine be used?

A doctor or nurse will combine paclitaxel (with albumin) injection with liquid and administer it intravenously (into a vein) over the course of 30 minutes. Paclitaxel (with albumin) injection is typically used once every three weeks to treat breast cancer. Paclitaxel (with albumin) injection is typically administered three times over a three-week period to treat non-small cell lung cancer. Usually administered as part of a 4-week cycle, paclitaxel (with albumin) injection is used to treat pancreatic cancer on days 1, 8, and 15. You can keep repeating these cycles for as long as your doctor advises.

Depending on how you respond to the drug and any side effects you have, your doctor may need to stop, modify, or interrupt your therapy. During your treatment, be careful to let your doctor know how you are feeling.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

The treatment of cancer of the head and neck, oesophagus (the tube connecting the mouth and stomach), bladder, endometrium (the lining of the uterus), and cervix may also involve the injection of paclitaxel (opening of the uterus). The dangers of using this drug for your illness should be discussed with your doctor.

What special precautions should I follow?

Before receiving paclitaxel (with albumin) injection,

  • If you have an allergy to paclitaxel, docetaxel, any other drugs, or human albumin, tell your doctor and pharmacist. If you are unsure whether a medication to which you are allergic contains human albumin, ask your doctor or pharmacist.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Incorporate any of the following: Carbamazepine (Carbatrol, Equetro, Tegretol); buspirone (Buspar); a number of drugs used to treat human immunodeficiency virus (HIV), including atazanavir (Reyataz, in Evotaz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, in Viekira Pak), and saquinavir (Invirase); clarithromycin (Biaxin, in Prevpac); telithromycin (Ketek; not available in the United States), midazolam, nefazodone, phenobarbital, repaglinide (Prandin, in Prandimet), rifampin (Rimactane, Rifadin, in Rifamate, in Rifater), rifampin (Rimactane, Rifadin, in Rifamate, in Rifater), rifamp (Halcion). Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects. It’s important to inform your doctor about all of the medications you are taking, including ones that do not appear on this list, as many other drugs may also interact with paclitaxel.
  • If you have or have had had heart, renal, or liver disease, let your doctor know.
  • Inform your doctor if you intend to father a child, are pregnant, or think you could get pregnant. While having paclitaxel (with albumin) injection, neither you nor your partner should become pregnant. To ensure that you are not pregnant when you start getting paclitaxel (with albumin) injection, your doctor may run a pregnancy test. During and for at least six months following your final dose of paclitaxel (with albumin) injection, female patients should utilise birth control. During your paclitaxel (with albumin) treatment and for three months after you finish getting paclitaxel (with albumin) injections, male patients should utilise birth control along with their female partners. Discuss effective birth control options with your doctor. Call your doctor if you or your partner become pregnant while receiving an injection of paclitaxel (with albumin). The foetus could be harmed by paclitaxel.
  • Inform your doctor if you are nursing a baby. While getting paclitaxel (with albumin) injection and for two weeks following your final dosage, you shouldn’t breastfeed.
  • Tell the surgeon or dentist if you are having surgery, including dental surgery, that you are receiving an injection of paclitaxel (with albumin).

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

There may be negative effects from paclitaxel when used with albumin. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Pain, swelling, redness, or sores at the site of the drug injection
  • Unusual weakness or fatigue
  • Nausea
  • Vomiting
  • Diarrhea
  • The throat or mouth feeling sore
  • Hair fall
  • Hand, foot, ankle, or lower leg swelling
  • Eyesight alterations or fuzziness
  • Less urinations
  • Mouth ache
  • Thirst
  • Cramping or aching muscles
  • Aching joints

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT WARNING section:

  • Tingling, numbness, or burning in the hands or feet
  • Sudden onset of a persistent dry cough
  • Breathing difficulty
  • Rash
  • Hives
  • Breathing or swallowing challenges
  • Eye, face, mouth, lips, tongue, or throat swelling
  • Light skin
  • Excessive fatigue
  • Abnormal bleeding or bruising
  • Chest pain
  • Irregular or slow heartbeat
  • Fainting

Other negative effects could result from using paclitaxel with albumin. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Light skin
  • Breathing difficulties
  • Excessive fatigue
  • Infection symptoms such as a sore throat, fever, chills, and others
  • Abnormal bleeding or bruising
  • Hands and feet tingling, burning, or going numb
  • Infections in the mouth

What other information should I know?

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Abraxane®
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