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A-Methapred (Generic Methylprednisolone Injection)

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Why is this medication prescribed?

Injections of methylprednisolone are used to treat life-threatening allergic reactions. Methylprednisolone injection is used to treat multiple sclerosis, lupus, gastroenteritis, and some forms of arthritis. Multiple sclerosis affects the nerves, while lupus causes the body to attack many of its own organs. Other disorders that affect the blood, skin, eyes, neurological system, thyroid, kidneys, and lungs are also treated with methylprednisolone injection. It is sometimes combined with other drugs to relieve the side effects of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). Methylprednisolone injection belongs to the corticosteroid drug class. The body’s normal natural production of corticosteroids is replaced in order to treat patients with low corticosteroid levels. It also helps cure other illnesses by lowering inflammation and redness and altering how the immune system functions.

How should this medicine be used?

Methylprednisolone injection is available as a powder to be combined with liquid and administered intravenously or intramuscularly (into a vein). Additionally, it is available as an injectable suspension that can be given intravenously, intra-articularly (into a joint), or intralesionally (into a lesion). Your illness and how you react to treatment will determine your individual dose regimen.

Methylprednisolone injection can be delivered to you in a hospital or other healthcare facility, or you can be given the medication to use at home. Your doctor will demonstrate how to inject the drug if you choose to use methylprednisolone injection at home. Make sure you comprehend these instructions, and if you have any issues, consult your healthcare professional. If you experience any issues while using methylprednisolone injection, ask your doctor what to do.

To ensure that you are always utilising the lowest dose of methylprednisolone injection that works for you, your doctor may adjust your dose during treatment. If your body is put under unusual stress, such as through surgery, illness, or infection, your doctor could also need to adjust your dose. During your therapy, let your doctor know if your symptoms grow better or worse, if you get sick or experience any changes in your health.

Other uses for this medicine

Additionally, methylprednisolone injection is occasionally used to relieve nausea and vomiting brought on by specific cancer chemotherapy regimens as well as to lower the risk of organ rejection. The dangers of using this drug for your illness should be discussed with your doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving methylprednisolone injection,

  • If you have any drug allergies, including those to benzyl alcohol, methylprednisolone, other drugs, or any of the substances in methylprednisolone injection, let your doctor and pharmacist know right once. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, herbal products, vitamins, and nutritional supplements you are now taking or intend to take. Any of the following should be mentioned: Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), and aminoglutethimide (Cytadren; no longer available in the United States); amphotericin B (Abelcet, Ambisome, Amphotec); anticoagulants (‘blood thinners’) like warfarin (Coumadin, Jantoven); and selective COX-2 inhibitors such as celecoxib (Celebrex); Cholinesterase inhibitors such donepezil (Aricept, in Namzaric), galantamine (Razadyne), neostigmine (Bloxiverz), pyridostigmine (Mestinon, Regonol), and rivastigmine (Exelon); cholestyramine (Prevalite); cyclosporine (Gengraf, Neoral, Sandimmune); diabetic drugs such as insulin; digoxin (Lanoxin); diuretics (‘water pills’); isoniazid (Laniazid, Rifamate, in Rifater); ketoconazole (Nizoral, Xolegel); phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); and rifampin. Other medications include erythromycin (E.E.S., Ery-Tab, Erythrocin, among others); oestrogens, including hormonal (Rifadin, Rimactane, in Rifamate, in Rifater). The dosage of your drugs may need to be adjusted, and your health may need to be closely watched for any negative effects.
  • If you have a fungal infection, tell your doctor (other than on your skin or nails). Most likely, your doctor will advise against using methylprednisolone injection. Tell your physician if you also suffer from idiopathic thrombocytopenic purpura (ITP; an ongoing condition that may cause easy bruising or bleeding due to an abnormally low number of platelets in the blood). If you have ITP, your doctor probably won’t inject you with methylprednisolone.
  • Inform your doctor if you have or have ever had: TB (a type of lung infection); cataracts (clouding of the lens of the eye); glaucoma (an eye disease); Cushing’s syndrome (a condition in which the body produces too much of the hormone cortisol); diabetes; high blood pressure; heart failure; a recent heart attack; emotional issues, depression or other types of mental illness; myasthenia gravis (a condition in which the muscles become weak); or osteoporosis; seizures; ulcers; or conditions affecting the thyroid, liver, kidneys, heart, or intestines. Also let your doctor know if you have any untreated bacterial, parasite, viral, or herpes eye infections, or any other sort of infection anywhere on your body (a type of infection that causes a sore on the eyelid or eye surface).
  • If you are breastfeeding a child or intend to become pregnant, let your doctor know. Call your doctor if you get pregnant while receiving an injection of methylprednisolone.
  • Tell the surgeon or dentist if you are having surgery, including dental surgery, that you are receiving an injection of methylprednisolone.
  • Without seeing your doctor, avoid getting any immunisations (shots to prevent infections).
  • It’s important to be aware that methylprednisolone injection may impair your capacity to fight infection and may shield you from the signs of infection. Avoid contact with sick persons while taking this drug, and wash your hands frequently. Avoid those who have the measles or chicken pox. If you believe you may have come into contact with someone who had the chicken pox or measles, call your doctor right once.

What special dietary instructions should I follow?

Your doctor may instruct you to follow a low-salt or a diet high in potassium or calcium. Your doctor may also prescribe or recommend a calcium or potassium supplement. Follow these directions carefully.

What side effects can this medication cause?

Side effects from methylprednisolone injection are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Dizziness
  • Sluggish wound and bruise healing
  • Acne
  • Dry, brittle, or thin skin
  • Under-the-skin blotches or streaks that are red or purple
  • Skin abrasions where the injection was made
  • Body fat accumulation or a shift in where you move it
  • Having trouble falling or staying asleep
  • Unsuitable happiness
  • Extreme mood swings and behavioural changes
  • Extreme fatigue
  • Depression
  • Increased perspiration
  • Muscle tremor
  • Aching joints
  • Dizziness
  • Irregular or nonexistent menstruation
  • Higher appetite
  • Hiccups

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Infection-related symptoms including a sore throat, a fever, chills, or a cough
  • Seizures
  • Vision issues
  • Swelling of the lower legs, hands, feet, ankles, lips, tongue, throat, arms, or other body parts
  • Breathing or swallowing challenges
  • Breathing difficulty
  • Gaining weight quickly
  • RashHives
  • Itching
  • Confusion
  • Patches of abnormal skin in the mouth, nose, or throat
  • Face, arms, legs, feet, or hands numb, burning, or tingly


Injections of methylprednisolone may retard a child’s growth. While using methylprednisolone injection, your child’s doctor will closely monitor your child’s growth. The hazards of giving your child this medication should be discussed with your child’s doctor.

Long-term methylprednisolone injection users run the risk of developing cataracts or glaucoma. During your therapy, ask your doctor how frequently you should have your eyes checked and any potential hazards associated with taking methylprednisolone injection.

Your chance of developing osteoporosis may increase if you have a methylprednisolone injection. Discuss the dangers of using this drug with your doctor.

Other negative effects from methylprednisolone injection are possible. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor how your body is responding to the methylprednisolone injection, your doctor will request a few lab tests.

Inform the lab staff and your doctor that you are using methylprednisolone injection prior to any laboratory test.

Tell the doctor or technician if you are getting any skin testing, such as allergy or tuberculosis tests, that you are taking methylprednisolone injection.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

Ask your pharmacist any inquiries you may have regarding the injection of methylprednisolone.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • A-Methapred®
  • Depo-Medrol®
  • Solu-Medrol®
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