Chemical Name: LISINOPRIL (lyse-IN-oh-pril) and HYDROCHLOROTHIAZIDE (hye-droe-klor-oh-THYE-a-zide)
Lisinopril/HCTZ is an angiotensin converting enzyme (ACE) inhibitor and thiazide diuretic combination used to treat high blood pressure. Lisinopril/HCTZ may also be used to treat other conditions as determined by your doctor.
WARNING: This drug can cause serious fetal harm if used during the last six months of pregnancy. If pregnancy occurs, stop using this drug and immediately contact your physician. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking dofetilide or ketanserin. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking non-steroidal anti-inflammatory medicine (such as ibuprofen, naproxen, or celecoxib), salicylates (such as aspirin), phenothiazines (such as thioridazine or chlorpromazine), diuretics (such as hydrochlorothiazide, furosemide, spironolactone, or triamterene), certain medicines for diabetes (such as glyburide, glipizide, tolbutamide, or insulin), pergolide, clozapine, eplerenone, indomethacin, lithium, potassium, azathioprine, diazoxide, digitoxin, digoxin, barbiturates (such as phenobarbital or butalbital), cholestyramine, corticotropin, colestipol, corticosteroids (such as prednisone), other medicines for high blood pressure, or narcotics (such as codeine). DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions such as a recent heart attack or other heart problems, blood vessel problems (such as aortic stenosis or stroke), kidney problems, hemodialysis, liver problems, electrolyte problems, a salt-restricted diet, lupus or scleroderma, diabetes, blood or bone marrow problems, asthma, high cholesterol, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of unusual swelling of your face, neck, throat, tongue, lips, or trunk (angioedema). Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
Follow the directions for using this medicine provided by your doctor. This medicine may be taken on an empty stomach or with food. STORE THIS MEDICINE at room temperature at 77 degrees F (25 degrees C) in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15-30 degrees C) is permitted. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
IF YOU HAVE HAD A SEVERE ALLERGIC REACTION to this medicine or any other sulfonamide medicine (such as sulfamethoxazole, glyburide, or probenecid), contact your doctor or pharmacist before taking this medicine. A severe reaction includes a severe rash, hives, breathing difficulties, or dizziness. If you have a question about whether you are allergic to this medicine or if a certain medicine is a sulfonamide, contact your doctor or pharmacist. DO NOT STOP TAKING THIS MEDICINE without discussing it with your doctor. Laboratory and/or medical tests, including blood pressure checks and blood electrolytes may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. THIS MEDICINE MAY AFFECT CERTAIN LAB TEST RESULTS including parathyroid function tests. Make sure laboratory personnel and your doctors know you use this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. CHECK WITH YOUR DOCTOR before drinking alcohol while you are taking this medicine. Alcohol may add to the effects of this medicine. THIS MEDICINE MAY CAUSE DIZZINESS, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine. THIS MEDICINE MAY CAUSE increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to this medicine. Use a sunscreen or protective clothing if you must be outside for a prolonged period. DO NOT USE A SALT SUBSTITUTE without checking with your doctor. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor. FOR WOMEN: USE OF THIS MEDICINE DURING PREGNANCY has resulted in fetal and newborn death. If you think you may be pregnant, contact your doctor immediately. THIS MEDICINE IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking this medicine. IF YOU HAVE DIABETES, this medicine may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine. MONITOR BLOOD GLUCOSE on a regular basis, as directed by your doctor.
Possible side effects
SIDE EFFECTS that may occur while taking this medicine include nausea, diarrhea, dizziness, headache, dry cough, or fatigue. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience a decrease in the amount of urine produced; loss of appetite; muscle weakness, pain, or cramps; decreased sexual ability; sore throat or fever; unusual tiredness or weakness; or numbness or tingling. CONTACT YOUR DOCTOR IMMEDIATELY if you experience symptoms of hyperglycemia (such as unusual thirst, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor); shortness of breath; persistent or severe nausea or vomiting; fast or irregular heartbeat; chest pain; swelling of face, lips, eyes, or tongue; unusual stomach pain; yellowing of skin or eyes; dark urine; severe dizziness; lightheadedness; fainting; or difficulty swallowing or breathing. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.
If you take too much
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include dizziness, fainting, and weakness.
BE SURE TO KNOW YOUR GOAL BLOOD PRESSURE. Check your blood pressure regularly. Keeping your blood pressure under control is important to help lower the risk of heart, kidney, and blood vessel problems. If your blood pressure is often higher than it should be and you are taking this medicine according to directions, tell your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.