Why is this medication prescribed?

Akeega is a medication used to treat prostate cancer. It is prescribed specifically for non-metastatic castration-resistant prostate cancer (nmCRPC), which means it’s used when prostate cancer continues to grow despite low levels of testosterone, but has not spread to other parts of the body.

How should this medicine be used?

Akeega (niraparib and abiraterone acetate) is a combination medication used in the treatment of certain types of prostate cancer. Here’s how it should generally be used, but it’s crucial to follow the specific instructions provided by your healthcare provider:

• Dosage: The typical dosage involves taking Akeega once daily. Your doctor will determine the exact dosage based on your medical condition and response to treatment.
• Administration: Take Akeega at the same time each day, with or without food. Swallow the tablet whole; do not crush, chew, or break it.
• Additional Medications: You may be prescribed a corticosteroid like prednisone to take alongside Akeega. This helps manage certain side effects and enhances the treatment’s effectiveness.
• Consistent Timing: Take Akeega at the same time every day to maintain consistent levels of the medication in your body.
• Missed Dose: If you miss a dose and it’s less than 12 hours until your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
• Regular Monitoring: Your doctor will likely monitor your blood pressure, liver function, and potassium levels regularly, as Akeega can affect these.

Always follow your healthcare provider’s specific instructions for using Akeega. If you have any questions or concerns about the medication, don’t hesitate to contact your healthcare team.

Other uses for this medicine

Akeega is primarily used for treating fungal infections of the skin. It’s generally not used for other conditions. If you’re considering it for another use, consult with a healthcare professional.

What special precautions should I follow?

Akeega (abemaciclib) is a medication used to treat certain types of breast cancer. Here are some special precautions to keep in mind:

• Monitor for Side Effects: Regularly monitor for side effects like diarrhea, nausea, vomiting, fatigue, and liver problems. Report any severe or persistent symptoms to your healthcare provider.
• Liver Function Tests: Regular blood tests to monitor liver function are important because Akeega can affect the liver.
• Drug Interactions: Inform your healthcare provider about all other medications you’re taking, including over-the-counter drugs and supplements, as Akeega can interact with other medications.
• Pregnancy and Breastfeeding: Akeega is not recommended during pregnancy or breastfeeding. Use effective contraception and inform your doctor if you become pregnant.
• Infection Risk: Be aware of signs of infection, as Akeega can affect your immune system. Report any symptoms like fever or sore throat.
• Grapefruit Juice: Avoid grapefruit juice as it can interact with Akeega and affect how the medication works.

Always follow your healthcare provider’s instructions and reach out to them with any concerns or questions about your treatment.

What special dietary instructions should I follow?

• Food Interactions: Generally, there are no specific dietary restrictions with Akeega. However, it’s always a good idea to maintain a balanced diet to support overall health.
• Alcohol: Limit alcohol consumption, as it can potentially interact with medications and affect your overall well-being.
• Grapefruit and Grapefruit Juice: Some medications interact with grapefruit, so consult your doctor or pharmacist about whether you should avoid grapefruit products.

What should I do if I forget a dose?

• Timing: If you realize you missed a dose and it is still several hours before your next dose, take it as soon as possible.
• If Close to Next Dose: If it’s almost time for your next dose, skip the missed dose. Do not take two doses at once to make up for the missed one.
• Contact Healthcare Provider: If you’re unsure what to do or have missed multiple doses, contact your healthcare provider for guidance.

What side effects can this medication cause?

Akeega (niraparib and abiraterone acetate) can cause a range of side effects, some of which may be serious. It’s important to monitor your health closely while taking this medication and report any concerning symptoms to your healthcare provider.

Common Side Effects:

• Fatigue: Feeling unusually tired or weak is a common side effect.
• Hypertension (High Blood Pressure): Akeega can cause an increase in blood pressure, which may need to be managed with medication.
• Nausea and Vomiting: Some patients may experience nausea or vomiting, which can usually be managed with dietary changes or anti-nausea medications.
• Diarrhea: Loose or frequent stools may occur and could lead to dehydration if severe.
• Decreased Appetite: You may lose your appetite or feel full quickly.
• Joint Pain (Arthralgia) and Muscle Pain (Myalgia): Akeega can cause discomfort in the joints and muscles.
• Edema (Swelling): Swelling of the legs, ankles, or feet may occur, often due to fluid retention.
• Anemia: A reduction in red blood cells can lead to symptoms like fatigue, shortness of breath, and dizziness.

Serious Side Effects:

• Heart Problems: Including chest pain, heart attack, or arrhythmias (irregular heartbeats). Monitor for symptoms like chest pain, shortness of breath, or palpitations.
• QT Prolongation: This can lead to serious heart rhythm issues.
• Liver Damage: Akeega can cause elevated liver enzymes or other signs of liver injury. Symptoms include yellowing of the skin or eyes (jaundice), dark urine, or severe abdominal pain.
• Hormonal Imbalance: Long-term use of corticosteroids (taken alongside Akeega) can lead to adrenal insufficiency, where the body does not produce enough cortisol. Symptoms include fatigue, weakness, and dizziness.
• Hypokalemia (Low Potassium Levels): Low potassium can cause muscle weakness, cramping, or irregular heartbeats.
• Severe Allergic Reactions: Although rare, signs of a severe allergic reaction include rash, itching, swelling (especially of the face/tongue/throat), severe dizziness, and difficulty breathing.
• Bone Density Loss (Osteoporosis): Akeega, especially when combined with corticosteroids, can increase the risk of osteoporosis and bone fractures.
• Renal (Kidney) Issues: Symptoms may include changes in urination, swelling, and fatigue.
• Pulmonary Embolism: Blood clots in the lungs can occur, leading to sudden shortness of breath, chest pain, or coughing up blood.
• Hot Flashes: Similar to those experienced during menopause, these may occur due to hormone suppression.
• Headaches: Mild to moderate headaches may occur.
• Mood Changes: Mood swings, depression, or anxiety could be experienced, potentially linked to hormonal changes.

Report them to your healthcare provider during your next visit. They might offer solutions to manage these effects. Contact your healthcare provider immediately if you experience severe or unusual side effects. In some cases, the dose may need to be adjusted, or alternative treatments may be considered.

Your doctor will monitor you for these side effects, but it’s important to keep them informed about how you’re feeling throughout your treatment with Akeega.

What should I know about storage and disposal of this medication?

Storage and Disposal of Akeega:

Storage:

• Temperature: Store Akeega at room temperature, typically between 20°C to 25°C (68°F to 77°F).
• Original Container: Keep the medication in its original container, tightly closed, and away from moisture and light.
• Out of Reach of Children and Pets: Ensure that Akeega is stored in a place where children and pets cannot access it.

Disposal:

• Do Not Flush: Do not flush Akeega down the toilet or pour it down the drain unless specifically instructed to do so.
• Medication Take-Back Programs: Use a drug take-back program if available. Many communities offer such programs for safe disposal.
• Follow Local Guidelines: If no take-back program is available, consult your pharmacist or local waste disposal company for guidelines on how to safely dispose of the medication.

In case of emergency/overdose

• Symptoms of Overdose: If you suspect an overdose, symptoms might include severe dizziness, fainting, or other serious side effects. Seek immediate medical attention.
• Contact Poison Control: In the U.S., you can call the Poison Help line at 1-800-222-1222 for guidance.
• Emergency Room: Go to the nearest emergency room if the person is unconscious, has trouble breathing, or is experiencing severe symptoms.

What other information should I know?

• Follow the Prescription: Take Akeega exactly as prescribed by your doctor. Do not take more or less than the recommended dose.
• Inform Your Doctor: Keep your healthcare provider informed about any other medications, supplements, or herbal products you are taking, as there may be interactions.
• Regular Monitoring: Your doctor will likely schedule regular blood tests and check-ups to monitor your response to the medication and adjust the dose if necessary.
• Missed Dose: If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not double up doses to make up for a missed one.
• Side Effects: Be aware of potential side effects such as nausea, fatigue, or changes in blood pressure. Report any unusual or severe symptoms to your healthcare provider immediately.
• Driving and Operating Machinery: Akeega can cause dizziness. Be cautious when driving or operating heavy machinery until you know how the medication affects you.

If you have any other questions or concerns about using Akeega, consult your healthcare provider for personalized advice and information.