Why is this medication prescribed?

Glofitamab-gxbm is prescribed for the treatment of certain types of lymphomas, specifically relapsed or refractory diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) in adult patients who have received at least two prior therapies.

How should this medicine be used?

The usage instructions for Glofitamab-gxbm typically involve the following steps:

• Administration: Glofitamab-gxbm is administered intravenously (IV), meaning it is infused directly into a vein.
• Dosage: The dosage and schedule of Glofitamab-gxbm can vary based on individual patient factors and the prescribing physician’s guidance. It typically involves a series of infusions over a specific period.
• Infusion Process: The infusion usually begins with a low initial dose, followed by an escalation to higher doses over several days to allow the body to adjust and minimize potential infusion-related reactions.
• Monitoring: During and after the infusion, patients are closely monitored for any signs of infusion-related reactions or other adverse effects.
• Frequency: Treatment with Glofitamab-gxbm may be repeated at certain intervals, depending on the response to therapy and the tolerance of the patient.
• Medical Supervision: Administration of Glofitamab-gxbm should be performed under the supervision of healthcare professionals experienced in the use of cancer therapies and in facilities equipped to manage potential infusion-related reactions.

It’s crucial for patients to follow their healthcare provider’s instructions precisely regarding the administration and monitoring of Glofitamab-gxbm to maximize its effectiveness and minimize any risks associated with treatment.

Other uses for this medicine

Currently, Glofitamab-gxbm is not widely approved or used for indications outside of relapsed or refractory DLBCL and MCL. Its use in clinical trials or off-label settings for other types of lymphomas or cancers would be considered investigational and would require specific protocols and approvals.

What special precautions should I follow?

When using Glofitamab-gxbm, several special precautions should be taken:

• Infusion Reactions: Glofitamab-gxbm can cause infusion-related reactions, which may include fever, chills, nausea, headache, and low blood pressure. Patients should be closely monitored during and after the infusion for these reactions. Medications to manage and prevent these reactions may be administered before the infusion.
• Infections: As with other immunotherapy agents, there is an increased risk of infections with Glofitamab-gxbm. Patients should be monitored for signs and symptoms of infection, and appropriate measures should be taken to prevent infections.
• Hypersensitivity: Patients with known hypersensitivity to any components of Glofitamab-gxbm should not receive the medication.
• Pregnancy and Breastfeeding: The effects of Glofitamab-gxbm on pregnancy and breastfeeding are not well studied. It should only be used during pregnancy if clearly needed and after careful consideration of the potential risks and benefits.
• Liver Function: Glofitamab-gxbm can affect liver function. Liver enzymes should be monitored before and during treatment.
• Other Medical Conditions: Patients with pre-existing medical conditions such as heart disease, lung disease, or autoimmune disorders may require special consideration and monitoring when receiving Glofitamab-gxbm.
• Pediatric Use: The safety and efficacy of Glofitamab-gxbm in pediatric patients have not been established.

Always follow the specific guidance provided by your healthcare provider regarding precautions and monitoring when receiving Glofitamab-gxbm. Regular communication with your healthcare team is essential to manage potential side effects and optimize treatment outcomes.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Glofitamab-gxbm. However, maintaining a balanced and nutritious diet is important for overall health and well-being during cancer treatment. If you have any specific dietary concerns or preferences, discuss them with your healthcare provider or a registered dietitian.

What side effects can this medication cause?

Glofitamab-gxbm, like any medication, can cause side effects. These side effects can vary in severity and may affect individuals differently. Here are some potential side effects associated with Glofitamab-gxbm:

• Infusion-related reactions: This is one of the most common side effects and can include symptoms such as fever, chills, nausea, vomiting, headache, fatigue, low blood pressure, and shortness of breath. These reactions typically occur during the infusion or shortly after and are managed by slowing down the infusion rate or temporarily stopping it, along with supportive medications.
• Infections: Glofitamab-gxbm can suppress the immune system, increasing the risk of infections. Common signs of infection include fever, cough, sore throat, and difficulty breathing.
• Low blood cell counts: Glofitamab-gxbm may cause a decrease in red blood cells (anemia), white blood cells (neutropenia), and platelets (thrombocytopenia). This can lead to symptoms such as fatigue, weakness, increased susceptibility to infections, and easy bruising or bleeding.
• Fatigue: Feeling tired or weak is a common side effect of Glofitamab-gxbm treatment.
• Digestive issues: Nausea, diarrhea, constipation, and abdominal pain can occur.
• Liver problems: Elevated liver enzymes (aspartate aminotransferase and alanine aminotransferase) may occur, indicating potential liver inflammation or damage.
• Fever: Some patients may experience fever unrelated to infusion reactions.
• Muscle and joint pain: This can occur as a result of the treatment.
• Allergic reactions: Rarely, severe allergic reactions (anaphylaxis) may occur.

It’s important to note that not all patients will experience these side effects, and the severity can vary. Your healthcare provider will monitor you closely during and after treatment to manage any side effects and adjust your treatment plan as needed. If you experience any concerning symptoms or side effects, promptly inform your healthcare team for appropriate management.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Glofitamab-gxbm is typically stored by healthcare providers in a clinical setting, such as a hospital or infusion center. It is important to store it according to the manufacturer’s instructions, usually at controlled room temperature. Proper storage ensures the medication’s stability and effectiveness.
• Disposal: Since Glofitamab-gxbm is administered under medical supervision and not typically prescribed for home use, disposal is handled by healthcare facilities following institutional protocols and local regulations for handling hazardous waste.

In case of emergency/overdose

• Emergency: If you experience severe infusion reactions or any other serious adverse effects during or after receiving Glofitamab-gxbm, seek immediate medical attention. Healthcare providers administering the infusion are trained to manage such emergencies with appropriate medications and supportive care.
• Overdose: Given the nature of Glofitamab-gxbm as an intravenously administered medication in a clinical setting, the risk of overdose is low under normal circumstances. However, in case of an overdose (receiving more than the prescribed dose accidentally), medical professionals would manage it by closely monitoring your condition and providing supportive care as necessary.

What other information should I know?

• Monitoring: You will be closely monitored during and after each infusion of Glofitamab-gxbm for any signs of infusion-related reactions, infections, changes in blood counts, or other potential side effects.
• Follow-up: Regular follow-up appointments with your healthcare provider are essential to assess your response to treatment, monitor for side effects, and adjust the treatment plan as needed.
• Patient Education: It’s important to understand the signs and symptoms of potential side effects and to promptly report any concerns to your healthcare team. This helps ensure timely intervention and management.
• Compliance: Follow your healthcare provider’s instructions regarding the Glofitamab-gxbm treatment schedule and any pre-medications recommended to minimize infusion-related reactions.
• Support: Engage with support services offered by your healthcare facility, such as oncology nurses, social workers, or support groups, to help manage the emotional and practical aspects of your treatment journey.

Always communicate openly with your healthcare team about any questions or concerns you may have regarding Glofitamab-gxbm treatment. They are your best resource for personalized guidance and support throughout your treatment course.