Why is this medication prescribed?

Capivasertib is prescribed primarily for the treatment of advanced solid tumors, particularly those that have specific genetic mutations or alterations. It is an investigational drug that targets and inhibits the Akt protein kinase, which plays a role in cell survival and growth pathways. Akt is often overactive in certain cancers, contributing to their progression. Capivasertib is being studied in clinical trials to assess its effectiveness in inhibiting these cancer-promoting pathways and potentially slowing down or stopping the growth of tumors.

Specifically, Capivasertib may be prescribed in the context of clinical trials or under special circumstances where other treatment options have been exhausted or are not suitable. Its use is typically guided by the specific genetic profile of the tumor and the patient’s overall health status.

How should this medicine be used?

Here’s how Capivasertib is typically used:

• Prescription: Capivasertib is prescribed by oncologists and other specialized physicians who manage cancer treatment.
• Indication: It is used in cases where the cancer has specific mutations that make it sensitive to AKT inhibition. These mutations are often found in cancers such as breast cancer and prostate cancer.
• Administration: Capivasertib is usually taken orally in the form of tablets or capsules. The dosage and schedule may vary depending on the specific cancer being treated, its stage, and the overall health of the patient.
• Combination Therapy: It is often used in combination with other cancer treatments like chemotherapy or other targeted therapies to enhance effectiveness.
• Monitoring: Patients taking Capivasertib require close monitoring by healthcare providers to assess its effectiveness and manage any potential side effects.
• Duration: Treatment duration with Capivasertib is determined by the oncologist based on ongoing assessment of the patient’s response to the medication and any side effects experienced.

It’s crucial for patients to follow their oncologist’s instructions precisely regarding dosage, timing of administration, and any additional guidelines for managing potential side effects or interactions with other medications.

Other uses for this medicine

Capivasertib is primarily being studied and used in clinical trials for its potential in treating various types of cancers. Apart from its main use in cancer treatment, there may be ongoing research exploring its effectiveness in other conditions, but as of my last update, it is not approved or widely used for other purposes besides oncology.

What special precautions should I follow?

When taking Capivasertib, it’s important to follow specific precautions to ensure safe and effective treatment:

• Medical Supervision: Capivasertib should only be used under the supervision of a qualified healthcare provider, typically an oncologist who specializes in cancer treatment.
• Dosage Adherence: Follow the prescribed dosage and schedule exactly as instructed by your doctor. Do not adjust the dosage unless specifically directed to do so by your healthcare provider.
• Monitoring: Regular monitoring of blood tests and other parameters may be necessary to check for any potential side effects or adverse reactions.
• Side Effects: Be aware of potential side effects such as nausea, diarrhea, rash, fatigue, and changes in blood counts. Report any unusual symptoms promptly to your healthcare provider.
• Interactions: Inform your doctor about all other medications, supplements, and herbal products you are taking, as Capivasertib may interact with other drugs.
• Pregnancy and Breastfeeding: Capivasertib may cause harm to unborn babies. It is important to discuss the risks and benefits with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Liver Function: Capivasertib can affect liver function. Your doctor may monitor your liver enzymes regularly during treatment.
• Allergies: Inform your healthcare provider about any known allergies or hypersensitivities, as Capivasertib may contain inactive ingredients that can cause allergic reactions.
• Driving and Activities: Capivasertib may cause fatigue or dizziness. Avoid driving or operating machinery until you know how this medication affects you.
• Storage: Store Capivasertib as directed by your pharmacist or healthcare provider, typically at room temperature away from moisture and heat.

Always consult your healthcare provider for specific guidance tailored to your individual health condition and circumstances when taking Capivasertib.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Capivasertib. However, maintaining a healthy diet is important for overall well-being during cancer treatment.

What should I do if I forget a dose?

• Timing: Take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule.
• Double Dosing: Do not take a double dose to make up for a missed one. Taking extra medication could increase the risk of side effects without improving treatment outcomes.
• Notify Your Healthcare Provider: Inform your healthcare provider about the missed dose during your next appointment or contact them for specific instructions if you are unsure about what to do.

What side effects can this medication cause?

Capivasertib, like many medications, can cause various side effects. It’s important to note that not all people will experience these side effects, and their severity can vary. Common side effects of Capivasertib include:

• Gastrointestinal Effects: Nausea, vomiting, diarrhea, constipation, abdominal pain.
• Skin Reactions: Rash, dry skin, itching.
• Fatigue: Feeling tired or weak.
• Changes in Appetite: Loss of appetite.
• Increased Blood Sugar Levels: Hyperglycemia (high blood sugar), which may require monitoring in patients with diabetes or predisposition to diabetes.
• Musculoskeletal Symptoms: Muscle pain, joint pain.
• Laboratory Abnormalities: Changes in blood counts (e.g., low white blood cells, low platelets), changes in liver function tests.
• Respiratory Symptoms: Cough, shortness of breath.
• Cardiovascular Effects: Increased blood pressure.
• Other: Headache, dizziness, altered taste sensation.

These side effects can vary in intensity from mild to severe. Some patients may experience more serious adverse effects that require immediate medical attention, such as severe allergic reactions, severe skin reactions, or significant changes in blood counts or liver function tests.

It’s essential for patients taking Capivasertib to communicate any side effects promptly to their healthcare provider. Your doctor can provide guidance on managing side effects and may adjust your treatment regimen if necessary to minimize discomfort and ensure the safety and effectiveness of your treatment. Regular monitoring through blood tests and check-ups is often recommended to monitor for any potential complications.

What should I know about storage and disposal of this medication?

Storage and Disposal of Capivasertib:

• Storage: Capivasertib should be stored according to the manufacturer’s instructions or as directed by your pharmacist. Typically, it should be stored at room temperature away from moisture and heat. Avoid storing it in the bathroom or kitchen where moisture levels can fluctuate.
• Handling: Handle Capivasertib tablets or capsules with care. Avoid crushing, breaking, or chewing them unless specifically instructed by your healthcare provider.
• Disposal: Properly dispose of any unused Capivasertib tablets or capsules. Do not flush them down the toilet or pour them into a drain unless instructed to do so. Ask your pharmacist or healthcare provider about the safe disposal of unused medications.

In case of emergency/overdose

• Seek Immediate Medical Attention: If you suspect an overdose or experience severe symptoms such as severe nausea, vomiting, diarrhea, dizziness, or difficulty breathing after taking Capivasertib, seek emergency medical help right away.
• Poison Control: You can also contact your local poison control center at 1-800-222-1222 (US) for guidance on what to do in case of overdose.

What other information should I know?

• Regular Follow-Up: Attend all scheduled appointments with your healthcare provider for monitoring your response to Capivasertib treatment and managing any potential side effects.
• Blood Tests: Your doctor may order regular blood tests to monitor your blood cell counts, liver function, and other parameters to ensure the medication is working properly and not causing harm.
• Medication Interaction: Inform your healthcare provider about all other medications, supplements, and herbal products you are taking, as Capivasertib can interact with other drugs.
• Pregnancy and Breastfeeding: Discuss with your doctor the potential risks and benefits of Capivasertib if you are pregnant, planning to become pregnant, or breastfeeding.
• Driving and Activities: Capivasertib may cause fatigue or dizziness. Use caution when driving or operating machinery until you know how this medication affects you.
• Storage and Handling: Keep Capivasertib out of reach of children and pets. Store it in a secure location to prevent accidental ingestion.
• Patient Support: Consider joining a support group for individuals undergoing cancer treatment to connect with others who may be taking similar medications and share experiences.

Always follow your healthcare provider’s instructions and guidance regarding Capivasertib to ensure safe and effective use of the medication.