Why is this medication prescribed?

Bendamustine injection is prescribed primarily for the treatment of certain types of cancer, particularly chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL). It belongs to a class of medications called alkylating agents, which work by interfering with the growth and spread of cancer cells in the body.

How should this medicine be used?

The dosage and administration of bendamustine injection can vary depending on the specific type of cancer being treated, as well as other factors such as the patient’s overall health and medical history. It’s typically administered intravenously (IV) by a healthcare professional in a clinical setting like a hospital or doctor’s office.

The exact dosage and treatment schedule will be determined by the prescribing healthcare provider, but typically, bendamustine injection is given in cycles, with each cycle consisting of several days of treatment followed by a period of rest to allow the body to recover. This pattern may be repeated over several weeks or months, depending on the response to treatment and the individual patient’s needs.

It’s crucial to follow the healthcare provider’s instructions regarding the dosage and schedule of bendamustine injection carefully. Never change the dosage or stop using the medication without consulting a healthcare professional, as doing so could reduce its effectiveness or lead to other complications. Additionally, be sure to discuss any concerns or potential side effects with your healthcare provider during treatment.

Other uses for this medicine

Some off-label uses of bendamustine injection may include:

• Multiple myeloma: Bendamustine may be used in combination with other medications to treat multiple myeloma, a type of cancer that affects plasma cells in the bone marrow.
• Hodgkin’s lymphoma: It may be used as part of a chemotherapy regimen for Hodgkin’s lymphoma, a cancer of the lymphatic system.
• Soft tissue sarcoma: Bendamustine may be used off-label in the treatment of certain types of soft tissue sarcoma, although its efficacy in this context is still being studied.
• Chronic myeloid leukemia (CML): In some cases, bendamustine may be used off-label in the treatment of chronic myeloid leukemia, a type of cancer that affects the blood and bone marrow.

What special precautions should I follow?

When using bendamustine injection, it’s essential to follow specific precautions to ensure its safe and effective use. Here are some key precautions to keep in mind:

• Medical History: Before starting bendamustine treatment, inform your healthcare provider about any medical conditions you have, especially if you have a history of liver or kidney problems, infections, or other serious illnesses. Also, disclose any medications, supplements, or herbal remedies you are currently taking, as they may interact with bendamustine.
• Pregnancy and Breastfeeding: Bendamustine can cause harm to an unborn baby, so it’s crucial to avoid becoming pregnant while receiving treatment. If you are pregnant or planning to become pregnant, discuss the risks and benefits of bendamustine with your healthcare provider. Similarly, it’s not recommended to breastfeed while using bendamustine, as it may pass into breast milk and harm the nursing infant.
• Infections: Bendamustine can suppress the immune system, making you more susceptible to infections. Take precautions to avoid exposure to infectious agents, such as washing your hands frequently, avoiding contact with sick individuals, and practicing good hygiene. If you develop signs of infection, such as fever, chills, or sore throat, contact your healthcare provider promptly.
• Blood Counts: Bendamustine can affect blood cell counts, leading to an increased risk of anemia, bleeding, and infections. Your healthcare provider will monitor your blood counts regularly during treatment. If you experience symptoms such as unusual bruising or bleeding, persistent fatigue, or signs of infection, notify your healthcare provider immediately.
• Allergic Reactions: Some individuals may experience allergic reactions to bendamustine, which can be severe. Inform your healthcare provider if you have a history of allergies to medications or other substances. Seek medical attention right away if you develop symptoms of an allergic reaction, such as rash, itching, swelling, difficulty breathing, or dizziness.
• Liver and Kidney Function: Bendamustine is metabolized by the liver and excreted by the kidneys. If you have liver or kidney impairment, your healthcare provider may adjust your dosage or monitor you more closely during treatment to prevent potential complications.
• Fertility: Bendamustine may impair fertility in both men and women. If you are concerned about preserving fertility, discuss this with your healthcare provider before starting treatment. They may be able to offer options for fertility preservation.

Always follow your healthcare provider’s instructions carefully and don’t hesitate to ask questions or raise concerns about bendamustine or any other aspect of your treatment plan.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are no specific dietary restrictions associated with bendamustine injection. However, it is essential to maintain a balanced diet and stay hydrated during treatment to support overall health and well-being. If you have any concerns about your diet or nutritional needs during treatment, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget a dose of bendamustine injection, it is crucial to contact your healthcare provider or treatment team for guidance. Do not try to make up for the missed dose by taking extra medication unless instructed to do so by your healthcare provider. They will advise you on the appropriate course of action based on your treatment schedule and medical condition. It’s important to adhere to the prescribed dosing schedule as closely as possible to ensure the effectiveness of the medication.

What side effects can this medication cause?

Bendamustine injection, like many cancer treatments, can cause various side effects. These side effects can vary in severity from person to person and depend on factors such as the dose of bendamustine, the duration of treatment, and individual health factors. Common side effects of bendamustine injection may include:

• Nausea and vomiting: These are among the most common side effects. Your healthcare provider may prescribe medications to help manage these symptoms.
• Fatigue: Feeling tired or weak is common during and after bendamustine treatment. Getting plenty of rest and engaging in light physical activity may help manage fatigue.
• Low blood cell counts: Bendamustine can reduce the production of blood cells in the bone marrow, leading to anemia (low red blood cell count), thrombocytopenia (low platelet count), and neutropenia (low white blood cell count). This can increase the risk of bleeding, infection, and fatigue.
• Hair loss: Some people may experience hair thinning or loss during treatment with bendamustine. Hair typically grows back after treatment ends.
• Fever and chills: These symptoms may occur during or shortly after infusion of bendamustine and are usually mild.
• Injection site reactions: Redness, swelling, or irritation at the site of injection may occur.
• Nerve damage (peripheral neuropathy): This can cause tingling, numbness, or weakness in the hands and feet. It’s usually temporary but can persist in some cases.
• Skin reactions: Rash, itching, or dry skin may occur.
• Digestive issues: Diarrhea, constipation, abdominal pain, and loss of appetite are possible side effects.
• Respiratory problems: Coughing, shortness of breath, or other respiratory symptoms may occur.
• Infections: Bendamustine can suppress the immune system, increasing the risk of infections.
• Kidney or liver problems: Rarely, bendamustine can cause kidney or liver damage. Your healthcare provider will monitor your kidney and liver function regularly during treatment.

It’s essential to report any side effects you experience to your healthcare provider promptly. They can provide guidance on managing side effects and may adjust your treatment plan if necessary to minimize discomfort and ensure your safety.

What should I know about storage and disposal of this medication?

Storage and disposal of Benralizumab injection:

• Storage: Bendamustine injection should be stored at room temperature, away from light and moisture. Do not freeze the medication. Keep it out of reach of children and pets. Follow any specific storage instructions provided by your healthcare provider or pharmacist.
• Disposal: Unused or expired bendamustine injection should be disposed of properly according to local regulations. Do not dispose of it in household trash or flush it down the toilet unless instructed to do so by your healthcare provider or pharmacist. Instead, consult your local pharmacy, healthcare facility, or waste disposal authority for guidance on safe disposal methods.

In case of emergency/overdose

In case of emergency or overdose of bendamustine injection, it’s essential to seek immediate medical attention. Symptoms of overdose may include severe nausea, vomiting, diarrhea, fever, chills, or signs of allergic reaction. Contact your healthcare provider, local emergency services, or go to the nearest emergency room for evaluation and treatment.

What other information should I know?

• Follow-up appointments: Attend all scheduled appointments with your healthcare provider for blood tests and monitoring during treatment. These appointments are essential for assessing your response to treatment and managing any side effects or complications.
• Avoid live vaccines: During bendamustine treatment, avoid receiving live vaccines, as they may pose a risk of infection. Discuss vaccination schedules and recommendations with your healthcare provider before starting treatment.
• Inform healthcare providers: Inform all healthcare providers involved in your care, including dentists and pharmacists, that you are receiving bendamustine treatment. They should be aware of your medication regimen to provide appropriate care and avoid potential drug interactions or complications.
• Patient support resources: Consider seeking support from patient advocacy groups, support groups, or counseling services to help cope with the emotional and practical challenges of cancer treatment. Your healthcare provider or local cancer center may be able to provide information about available resources.
• Medication adherence: Take bendamustine injection exactly as prescribed by your healthcare provider. Do not change the dosage or frequency of administration without consulting them first. If you have any questions or concerns about your treatment regimen, discuss them with your healthcare provider.

By following these guidelines and staying informed about bendamustine injection treatment, you can help ensure its safe and effective use as part of your cancer therapy.