WARNING

Glofitamab-gxmb is an investigational bispecific antibody being studied for the treatment of certain types of cancer. While it holds promise for improving cancer treatment, like all medications, it carries potential risks and side effects. Some of the risks associated with Glofitamab-gxmb may include:

• Infusion reactions: These are common with many monoclonal antibodies and can range from mild to severe allergic reactions during or shortly after the infusion of the medication.
• Cytokine release syndrome (CRS): This is a systemic inflammatory response that can occur as a result of the activation and proliferation of immune cells. It can range from mild symptoms like fever and nausea to more severe symptoms like low blood pressure and organ dysfunction.
• Neurotoxicity: Some patients may experience neurological side effects such as confusion, delirium, seizures, or other symptoms affecting the nervous system.
• Infections: By suppressing certain components of the immune system, Glofitamab-gxmb may increase the risk of infections. This risk could be especially significant in patients already compromised by their underlying disease or other treatments.
• Tumor lysis syndrome (TLS): This is a potentially life-threatening complication that can occur when cancer cells are rapidly destroyed, releasing their contents into the bloodstream faster than the body can eliminate them. This can lead to electrolyte imbalances, kidney failure, and other serious complications.
• Hematological toxicity: Glofitamab-gxmb may cause decreases in blood cell counts, including red blood cells, white blood cells, and platelets, which can lead to anemia, increased risk of infections, and bleeding.
• Other side effects: Other potential side effects may include fatigue, gastrointestinal disturbances, skin reactions, and muscle weakness.

It’s important for patients considering Glofitamab-gxmb treatment to discuss the potential risks and benefits thoroughly with their healthcare provider. Not everyone will experience these side effects, and some may be manageable with supportive care or dose adjustments. Close monitoring during treatment can help mitigate risks and manage any adverse effects that may arise.

Why is this medication prescribed?

Glofitamab-gxmb is a prescription medication used for the treatment of certain types of cancer, specifically diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). It is a type of immunotherapy known as a bispecific antibody, designed to target cancer cells and trigger the body’s immune system to attack them.

How should this medicine be used?

Glofitamab-gxmb is typically administered intravenously (IV) by a healthcare professional in a clinical setting such as a hospital or infusion center. Here’s how it is generally used:

• Administration: Glofitamab-gxmb is given through a needle placed into a vein, usually in the arm or hand. The infusion is typically delivered over a specified period of time, which can vary depending on factors such as the dosage and the patient’s tolerance.
• Dosage: The dosage of Glofitamab-gxmb can vary based on factors such as the type and stage of cancer being treated, the patient’s weight, and overall health. Your healthcare provider will determine the appropriate dosage for you.
• Treatment Schedule: Glofitamab-gxmb is usually given in cycles, with each cycle consisting of several doses over a set period of time. The specific treatment schedule will be determined by your healthcare provider based on your individual circumstances. It’s essential to follow the treatment schedule as prescribed to ensure the best possible outcomes.
• Monitoring: During and after the infusion, your healthcare provider will monitor you closely for any signs of infusion reactions or other adverse effects. This may include regular checks of vital signs and blood tests to assess your response to treatment.
• Follow-up: After receiving Glofitamab-gxmb, your healthcare provider will schedule follow-up appointments to monitor your progress, assess any side effects, and adjust your treatment plan as needed.

It’s crucial to follow your healthcare provider’s instructions carefully and communicate any concerns or side effects you may experience during treatment. Additionally, be sure to attend all scheduled appointments and adhere to the recommended treatment schedule to optimize the effectiveness of Glofitamab-gxmb therapy.

Other uses for this medicine

As for other uses for Glofitamab-gxmb, it is primarily indicated for the treatment of certain types of cancer, particularly non-Hodgkin’s lymphoma. There may be ongoing research into other potential uses for this medication, but its primary use currently lies in cancer treatment.

What special precautions should I follow?

Regarding special precautions when using Glofitamab-gxmb, it’s essential to follow your healthcare provider’s instructions closely. Here are some general precautions that may apply:

• Medical supervision: Glofitamab-gxmb is typically administered in a healthcare setting by trained medical professionals who can monitor for any adverse reactions during and after infusion.
• Pre-treatment evaluation: Before starting Glofitamab-gxmb therapy, your healthcare provider may perform tests to assess your overall health, including blood tests, imaging scans, and cardiac evaluations.
• Infusion-related precautions: Infusion reactions are common with many monoclonal antibodies, so patients may receive pre-medications such as antihistamines or corticosteroids to help prevent or mitigate these reactions. Vital signs are usually monitored during and after infusion.
• Infection prevention: Since Glofitamab-gxmb may suppress the immune system, it’s essential to take precautions to reduce the risk of infections. This may include practicing good hand hygiene, avoiding close contact with sick individuals, and receiving recommended vaccinations.
• Monitoring for side effects: Your healthcare provider will likely monitor you closely for potential side effects of Glofitamab-gxmb treatment, such as cytokine release syndrome, neurotoxicity, and hematological toxicity. Prompt reporting of any new or worsening symptoms is crucial for early intervention.
• Follow-up care: Regular follow-up appointments with your healthcare provider are essential to assess your response to treatment, monitor for any signs of disease progression or recurrence, and manage any ongoing side effects.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, it’s crucial to discuss the risks and benefits of Glofitamab-gxmb therapy with your healthcare provider. The potential risks to the fetus or infant must be weighed against the potential benefits of treatment.

Always consult with your healthcare provider for personalized advice and recommendations regarding Glofitamab-gxmb treatment and any specific precautions that may apply to your individual situation.

What special dietary instructions should I follow?

Regarding special dietary instructions for Glofitamab-gxmb, there are typically no specific dietary restrictions associated with its use. However, maintaining a balanced and nutritious diet can support overall health and well-being during cancer treatment. It’s essential to stay hydrated and consume a variety of foods rich in vitamins, minerals, and protein to support your immune system and overall recovery.

What should I do if I forget a dose?

If you forget a dose of Glofitamab-gxmb, it’s crucial to contact your healthcare provider or treatment facility promptly for guidance. Missing a dose may impact the effectiveness of your treatment, so your healthcare provider can advise you on the best course of action, which may include rescheduling the missed dose or adjusting your treatment plan as necessary. Never attempt to administer a missed dose without consulting your healthcare provider first.

What side effects can this medication cause?

Glofitamab-gxmb, like many medications, can cause side effects, which can vary from person to person. Common side effects associated with Glofitamab-gxmb may include:

• Infusion reactions: These reactions can occur during or shortly after the infusion of Glofitamab-gxmb and may include symptoms such as fever, chills, flushing, itching, rash, shortness of breath, and low blood pressure.
• Cytokine release syndrome (CRS): CRS is a systemic inflammatory response that can occur as a result of the activation and proliferation of immune cells. Symptoms may include fever, headache, fatigue, muscle aches, nausea, vomiting, diarrhea, low blood pressure, and organ dysfunction.
• Neurological toxicity: Some patients may experience neurological side effects such as confusion, delirium, seizures, tremors, or other symptoms affecting the nervous system.
• Hematological toxicity: Glofitamab-gxmb may cause decreases in blood cell counts, including red blood cells, white blood cells, and platelets, which can lead to anemia, increased risk of infections, and bleeding.
• Infections: By suppressing certain components of the immune system, Glofitamab-gxmb may increase the risk of infections, including bacterial, viral, and fungal infections.
• Tumor lysis syndrome (TLS): This is a potentially life-threatening complication that can occur when cancer cells are rapidly destroyed, leading to the release of cellular contents into the bloodstream. Symptoms may include electrolyte imbalances, kidney dysfunction, and cardiac arrhythmias.
• Fatigue: Feeling tired or fatigued is a common side effect of cancer treatment, including Glofitamab-gxmb.
• Gastrointestinal disturbances: Some patients may experience nausea, vomiting, diarrhea, or other gastrointestinal symptoms during or after treatment with Glofitamab-gxmb.

It’s important to note that not everyone will experience these side effects, and some may be more severe than others. Additionally, there may be other side effects not listed here. It’s essential to discuss any concerns or symptoms with your healthcare provider, as they can provide guidance and support for managing side effects during Glofitamab-gxmb treatment.

What should I know about storage and disposal of this medication?

Storage and disposal of Glofitamab-gxmb:

• Storage: Glofitamab-gxmb should be stored according to the manufacturer’s instructions, typically in a refrigerator at a controlled temperature. It should be kept in its original packaging until ready for use to protect it from light and moisture. Do not freeze the medication. If you have any questions about how to store Glofitamab-gxmb, consult your healthcare provider or pharmacist.
• Disposal: Unused or expired Glofitamab-gxmb should be disposed of properly according to local regulations or guidelines. Do not dispose of it in household trash or flush it down the toilet unless specifically instructed to do so. Your healthcare provider or pharmacist can provide guidance on the proper disposal method for Glofitamab-gxmb.

In case of emergency/overdose

In case of emergency or overdose of Glofitamab-gxmb, it’s essential to seek immediate medical attention. Symptoms of overdose may include severe infusion reactions, cytokine release syndrome, neurological toxicity, or other severe adverse effects. If you or someone else may have overdosed on Glofitamab-gxmb, contact your healthcare provider, local poison control center, or emergency room for assistance.

What other information should I know?

• Monitoring: Regular monitoring by your healthcare provider is crucial during treatment with Glofitamab-gxmb to assess your response to treatment, monitor for side effects, and adjust your treatment plan as needed.
• Follow-up care: Attend all scheduled appointments for monitoring and follow-up care as recommended by your healthcare provider. Be sure to report any new or worsening symptoms to your healthcare provider promptly.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Glofitamab-gxmb treatment with your healthcare provider. It’s essential to weigh the potential risks to the fetus or infant against the potential benefits of treatment.
• Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Glofitamab-gxmb may interact with other medications.
• Patient support: Your healthcare provider or treatment facility may offer resources and support services to help you manage your treatment and cope with any challenges or concerns that arise during Glofitamab-gxmb therapy.

Always consult with your healthcare provider or pharmacist if you have any questions or concerns about Glofitamab-gxmb or its use. They can provide personalized guidance and recommendations based on your individual needs and circumstances.