WARNING

Tenapanor (brand name Ibsrela) is a medication used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). While it can be effective in managing these conditions, like any medication, it carries certain risks and side effects. Here are some of the potential risks associated with taking Tenapanor:

• Gastrointestinal Side Effects: The most common side effects of Tenapanor include diarrhea, abdominal pain, flatulence, and bloating. These gastrointestinal side effects may occur especially during the initial stages of treatment.
• Dehydration: Diarrhea caused by Tenapanor can lead to dehydration if fluid intake is not sufficient. It is important to stay hydrated and monitor fluid intake while taking this medication.
• Electrolyte Imbalance: Prolonged diarrhea can result in electrolyte imbalances, particularly affecting levels of sodium, potassium, and magnesium in the body. This can lead to symptoms such as weakness, dizziness, and irregular heartbeat.
• Decreased Medication Absorption: Tenapanor may decrease the absorption of certain medications taken orally, such as antibiotics, birth control pills, and certain vitamins. It is important to discuss potential interactions with your healthcare provider.
• Allergic Reactions: Some individuals may experience allergic reactions to Tenapanor, although this is rare. Symptoms of an allergic reaction may include rash, itching, swelling, severe dizziness, or trouble breathing.
• Contraindications: Tenapanor is contraindicated in individuals with a history of bowel obstruction, severe diarrhea, or conditions that may predispose to bowel obstruction. It should also be used with caution in individuals with severe renal impairment.
• Pregnancy and Breastfeeding: The safety of Tenapanor during pregnancy and breastfeeding has not been established. It is important to discuss the risks and benefits with your healthcare provider if you are pregnant or breastfeeding.

It’s crucial to talk to your healthcare provider about any concerns or potential risks associated with taking Tenapanor, and to report any adverse reactions or side effects experienced while taking the medication.

Why is this medication prescribed?

Tenapanor (brand name: Ibsrela) is prescribed for the treatment of irritable bowel syndrome with constipation (IBS-C) in adults. It works by reducing the absorption of dietary sodium in the intestines, which in turn increases the secretion of water into the intestines. This results in softer stools and improved bowel movements, alleviating symptoms of constipation associated with IBS.

How should this medicine be used?

Here’s how Tenapanor is typically used:

• Dosage: The usual recommended dosage of Tenapanor is 50 mg twice daily with food. Your healthcare provider may adjust the dosage based on your individual response to the medication and your medical condition.
• Administration: Tenapanor tablets should be swallowed whole with a glass of water, and they should be taken with food. Do not crush, chew, or break the tablets.
• Timing: Take Tenapanor consistently at the same times each day to maintain steady levels of the medication in your body and to maximize its effectiveness.
• Follow-up: Your healthcare provider may monitor your response to Tenapanor and may adjust your dosage or treatment plan accordingly. Be sure to keep all follow-up appointments and communicate any concerns or changes in symptoms with your healthcare provider.
• Lifestyle Changes: In addition to taking Tenapanor, your healthcare provider may recommend dietary and lifestyle changes to help manage your symptoms of IBS-C or CIC. This may include increasing fiber intake, staying hydrated, regular exercise, and stress management techniques.

It’s important to follow your healthcare provider’s instructions carefully when taking Tenapanor and to not exceed the prescribed dosage. If you have any questions or concerns about how to use Tenapanor, be sure to discuss them with your healthcare provider or pharmacist.

Other uses for this medicine

Tenapanor (brand name Ibsrela) is primarily prescribed for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). However, there are no other FDA-approved uses for Tenapanor beyond these conditions.

What special precautions should I follow?

Special precautions should be taken when using Tenapanor. Here are some important considerations:

• Bowel Obstruction: Tenapanor is contraindicated in individuals with a history of bowel obstruction. It should not be used if you have a known or suspected bowel obstruction.
• Severe Diarrhea: Tenapanor can cause diarrhea as a common side effect. If you experience severe or persistent diarrhea, contact your healthcare provider. They may need to adjust your dosage or discontinue the medication.
• Medication Interactions: Tenapanor may interact with certain medications, decreasing their absorption when taken orally. This includes antibiotics, birth control pills, and certain vitamins. Inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting Tenapanor.
• Renal Impairment: Tenapanor should be used with caution in individuals with severe renal impairment. Dosage adjustments may be necessary in these cases.
• Pregnancy and Breastfeeding: The safety of Tenapanor during pregnancy and breastfeeding has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Tenapanor with your healthcare provider.
• Allergic Reactions: While rare, allergic reactions to Tenapanor can occur. Seek medical attention immediately if you experience symptoms of an allergic reaction, such as rash, itching, swelling, severe dizziness, or trouble breathing.
• Fluid Intake: Because Tenapanor can cause diarrhea, it is important to maintain adequate fluid intake to prevent dehydration.
• Follow-up Monitoring: Your healthcare provider may monitor your response to Tenapanor and may need to adjust your dosage or treatment plan based on your individual needs.

Always follow your healthcare provider’s instructions and guidance when taking Tenapanor, and do not hesitate to ask any questions or raise concerns about its use and potential side effects.

What special dietary instructions should I follow?

Special Dietary Instructions:

• Fluid Intake: Ensure adequate fluid intake while taking Tenapanor to prevent dehydration, especially due to the risk of diarrhea.
• Fiber Intake: Maintain a balanced diet rich in fiber, unless otherwise directed by your healthcare provider. Fiber can help regulate bowel movements and complement the effects of Tenapanor.

What should I do if I forget a dose?

If you forget to take a dose of Tenapanor, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

What side effects can this medication cause?

Tenapanor (brand name Ibsrela) can cause various side effects, ranging from mild to severe. It’s important to note that not all individuals will experience these side effects, and some may experience none at all. Common side effects of Tenapanor include:

• Diarrhea: Diarrhea is the most common side effect of Tenapanor. It can range from mild to severe and may lead to dehydration if not managed properly.
• Abdominal Pain: Some individuals may experience abdominal discomfort or pain while taking Tenapanor.
• Flatulence: Increased gas production and flatulence are common side effects of Tenapanor.
• Bloating: Bloating or a feeling of fullness in the abdomen may occur as a side effect of Tenapanor.
• Headache: Headaches have been reported as a side effect of Tenapanor in some individuals.
• Nausea: Nausea or feelings of queasiness may occur while taking Tenapanor.
• Vomiting: Some individuals may experience vomiting as a side effect of Tenapanor.
• Dizziness: Dizziness or lightheadedness may occur, particularly if dehydration occurs due to diarrhea.
• Fatigue: Some individuals may experience fatigue or weakness while taking Tenapanor.
• Decreased Appetite: A decrease in appetite may occur as a side effect of Tenapanor.

It’s important to note that these are not all of the possible side effects of Tenapanor. Some individuals may experience other side effects not listed here. If you experience any severe or persistent side effects while taking Tenapanor, it’s important to contact your healthcare provider for further evaluation and guidance. Additionally, if you have any concerns about potential side effects, discuss them with your healthcare provider before starting Tenapanor.

What should I know about storage and disposal of this medication?

Storage and disposal of Tenapanor (Ibsrela):

• Store Tenapanor tablets at room temperature between 20°C to 25°C (68°F to 77°F).
• Keep the medication in its original packaging and away from moisture and heat.
• Keep Tenapanor out of reach of children and pets.
• Do not use Tenapanor beyond its expiration date.
• Dispose of any unused or expired Tenapanor tablets according to local regulations or guidelines. You can consult your pharmacist or healthcare provider for proper disposal instructions.

In case of emergency/overdose

• If you suspect an overdose of Tenapanor or experience severe symptoms such as severe diarrhea, dehydration, or any other unusual symptoms, seek immediate medical attention or contact your local poison control center.
• Be prepared to provide information about the amount of Tenapanor ingested, the time of ingestion, and any symptoms experienced.

What other information should I know?

• Inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting Tenapanor to avoid potential drug interactions.
• Attend all scheduled follow-up appointments with your healthcare provider to monitor your response to Tenapanor and make any necessary adjustments to your treatment plan.
• Follow your healthcare provider’s instructions carefully regarding the dosage and administration of Tenapanor.
• Be aware of the potential side effects of Tenapanor and report any severe or persistent symptoms to your healthcare provider.
• If you have any questions or concerns about Tenapanor or its use, consult your healthcare provider or pharmacist for clarification and guidance.
• Do not share Tenapanor with others, even if they have similar symptoms, as it may not be suitable for their condition.

Following these guidelines will help ensure the safe and effective use of Tenapanor (Ibsrela) and minimize the risk of adverse effects or complications.