WARNING

Rybelsus is a brand name for the medication semaglutide, which is used to treat type 2 diabetes. Like any medication, Rybelsus comes with potential risks and side effects. It’s important to note that the information provided here is not exhaustive, and individuals should consult their healthcare professionals for personalized advice. Some potential risks associated with Rybelsus include:

• Hypoglycemia: Rybelsus, when used in combination with other medications that lower blood sugar, may increase the risk of hypoglycemia (low blood sugar). This can lead to symptoms such as shakiness, sweating, irritability, and, in severe cases, unconsciousness.
• Gastrointestinal Effects: Common side effects of Rybelsus include nausea, vomiting, diarrhea, and abdominal pain. These symptoms can be temporary and may improve over time.
• Pancreatitis: There have been reports of pancreatitis (inflammation of the pancreas) with the use of GLP-1 receptor agonists like Rybelsus. Symptoms of pancreatitis include persistent severe abdominal pain, often radiating to the back, and may be accompanied by nausea and vomiting.
• Thyroid C-Cell Tumors: In animal studies, semaglutide has been associated with an increased risk of thyroid C-cell tumors. While the relevance of this finding to humans is not fully established, it’s a potential concern.
• Renal Impairment: Some GLP-1 receptor agonists, including Rybelsus, may have effects on kidney function. Monitoring kidney function is important, especially in individuals with pre-existing renal impairment.
• Allergic Reactions: Allergic reactions, including serious ones, have been reported with the use of semaglutide. Symptoms may include swelling of the face, lips, tongue, or throat, and difficulty breathing.

It’s crucial for individuals prescribed Rybelsus to communicate with their healthcare providers about their medical history, existing conditions, and any other medications they are taking. This helps healthcare professionals assess the overall risk-benefit profile and tailor the treatment plan accordingly. As with any medication, the decision to use Rybelsus should be made after careful consideration of individual health status and potential risks.

Why is this medication prescribed?

Rybelsus (semaglutide) is a prescription medication used to treat type 2 diabetes. It belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. Rybelsus works by increasing the release of insulin and reducing the amount of glucagon produced by the pancreas. These actions help lower blood sugar levels in individuals with type 2 diabetes.

Rybelsus is typically prescribed to improve glycemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise. It is often used when diet and exercise alone do not provide adequate blood sugar control.

How should this medicine be used?

Rybelsus is taken orally and comes in tablet form. Here are general guidelines on how Rybelsus is usually used:

• Dosage: The recommended starting dose is often 7 mg once daily. After 30 days, the dose may be increased to 14 mg once daily if additional blood sugar control is needed.
• Administration: Rybelsus should be taken on an empty stomach, at least 30 minutes before the first food, beverage, or other oral medications of the day. It should be taken with no more than 4 ounces of plain water.
• Swallowing the Tablet: The tablet should be swallowed whole and not crushed, split, or chewed. It’s important to ensure that the tablet is ingested intact.
• Consistency in Timing: It is advisable to take Rybelsus at the same time each day to maintain consistency in blood sugar control.
• Diet and Exercise: Rybelsus is typically used as an adjunct to diet and exercise. Patients are encouraged to continue a healthy diet and exercise routine as recommended by their healthcare provider.
• Monitoring: Regular monitoring of blood sugar levels and other relevant parameters is essential to assess the effectiveness of the treatment and adjust the dosage if needed.

It’s crucial for individuals to follow their healthcare provider’s instructions and attend regular follow-up appointments to monitor their response to Rybelsus and manage any potential side effects or complications. As with any medication, individualized guidance from a healthcare professional is essential, and patients should not adjust their dosage or discontinue the medication without consulting their healthcare provider.

Other uses for this medicine

Rybelsus is primarily indicated for the treatment of type 2 diabetes. It is not approved for use in type 1 diabetes or diabetic ketoacidosis. Consult your healthcare provider for information about the specific uses of Rybelsus.

What special precautions should I follow?

As for special precautions, individuals using Rybelsus should be aware of the following:

• Hypoglycemia: Rybelsus, especially when used in combination with other antidiabetic medications, can increase the risk of hypoglycemia (low blood sugar). It’s important to monitor blood sugar levels regularly and be aware of the signs and symptoms of hypoglycemia.
• Gastrointestinal Effects: Rybelsus may cause gastrointestinal side effects, including nausea, vomiting, diarrhea, and abdominal pain. These symptoms are usually mild and may improve over time.
• Pancreatitis: There have been reports of pancreatitis (inflammation of the pancreas) with the use of GLP-1 receptor agonists like Rybelsus. Patients should be monitored for signs and symptoms of pancreatitis, such as severe abdominal pain, and seek medical attention if they occur.
• Thyroid C-Cell Tumors: There is a potential risk of thyroid C-cell tumors based on animal studies with semaglutide. The relevance of this finding to humans is not fully established.
• Renal Impairment: Rybelsus may have effects on kidney function. Monitoring kidney function is important, especially in individuals with pre-existing renal impairment.
• Allergic Reactions: Allergic reactions, including serious ones, have been reported with the use of semaglutide. Seek medical attention if you experience symptoms such as swelling of the face, lips, tongue, or throat, and difficulty breathing.

It’s essential to inform your healthcare provider about your medical history, existing conditions, and any other medications you are taking before starting Rybelsus. This information helps healthcare professionals assess the overall risk-benefit profile and tailor the treatment plan to individual needs. Always follow your healthcare provider’s instructions and attend regular check-ups. If you have specific concerns or questions about Rybelsus, discuss them with your healthcare provider for personalized guidance.

What special dietary instructions should I follow?

Special Dietary Instructions for Rybelsus:

• Timing of Administration: Take Rybelsus on an empty stomach, at least 30 minutes before the first meal, drink, or other oral medications of the day. It should be taken with no more than 4 ounces of plain water.
• Consistent Meal Timing: Try to maintain a consistent meal schedule to help optimize the effects of Rybelsus on blood sugar levels.

What should I do if I forget a dose?

• Within 1 Hour of Forgetting: If you forget to take Rybelsus and remember within 1 hour of the missed dose, take it immediately. You can then resume your normal dosing schedule the next day.
• More Than 1 Hour After Forgetting: If it’s more than 1 hour after the missed dose, skip the missed dose and take the next scheduled dose on the following day. Do not double up on doses to make up for a missed one.
• Consistency is Key: It’s essential to take Rybelsus consistently to maintain stable blood sugar control. If you’re unsure about what to do after missing a dose, consult your healthcare provider for guidance.

What side effects can this medication cause?

Rybelsus (semaglutide), like any medication, may cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects that are not listed here. If you are prescribed Rybelsus, your healthcare provider will closely monitor your response to the medication. Common side effects of Rybelsus include:

• Gastrointestinal Effects: Nausea, vomiting, diarrhea, and abdominal pain are among the most common side effects. These symptoms are usually mild and tend to improve over time.
• Hypoglycemia: Taking Rybelsus in combination with other antidiabetic medications can increase the risk of hypoglycemia (low blood sugar). Symptoms may include shakiness, sweating, irritability, and confusion.
• Allergic Reactions: While uncommon, allergic reactions have been reported. Seek medical attention if you experience symptoms such as swelling of the face, lips, tongue, or throat, and difficulty breathing.
• Pancreatitis: There have been reports of pancreatitis (inflammation of the pancreas). Seek medical attention if you experience persistent severe abdominal pain.
• Thyroid Tumors: In animal studies, semaglutide has been associated with an increased risk of thyroid C-cell tumors. The relevance of this finding to humans is not fully established.
• Renal Impairment: Some GLP-1 receptor agonists, including Rybelsus, may have effects on kidney function. Regular monitoring of kidney function is advisable.

It’s important to report any unusual or severe symptoms to your healthcare provider promptly. Additionally, discuss your medical history, including any pre-existing conditions or medications you are taking, with your healthcare provider before starting Rybelsus.

This list is not exhaustive, and individual responses to medications can vary. Always consult with your healthcare provider for personalized information and guidance. If you experience a medical emergency or severe side effects, seek immediate medical attention.

What should I know about storage and disposal of this medication?

Storage and Disposal of Rybelsus:

• Storage:
  • Store Rybelsus at room temperature between 68°F to 77°F (20°C to 25°C).
  • Keep the medication in its original container and away from moisture and direct sunlight.
  • Do not store Rybelsus in the bathroom.
• Disposal:
  • Dispose of unused or expired Rybelsus properly. Check with your healthcare provider or local pharmacy for information on drug take-back programs in your community.
  • If no take-back program is available, follow the FDA guidelines for disposing of medications. Mix the tablets with an unappealing substance (such as dirt or used coffee grounds) in a sealed plastic bag before throwing it in the trash. Remove any personal information from the medication packaging before disposal.

In case of emergency/overdose

In case of an emergency or suspected overdose of Rybelsus, seek immediate medical attention or contact a poison control center. The National Poison Control Center can be reached at 1-800-222-1222 in the United States. Symptoms of overdose may include severe nausea, vomiting, dehydration, and hypoglycemia (low blood sugar).

What other information should I know?

• Regular Monitoring: Regularly monitor your blood sugar levels as recommended by your healthcare provider. This helps assess the effectiveness of Rybelsus and adjust the dosage if needed.
• Medical and Lab Tests: Attend regular follow-up appointments with your healthcare provider for medical and laboratory tests to evaluate your response to Rybelsus and to detect any potential side effects or complications.
• Missed Dose: If you forget to take a dose, take it within 1 hour of the missed dose. If it’s more than 1 hour after the missed dose, skip it and take the next scheduled dose. Do not double up on doses.
• Inform Healthcare Provider: Keep your healthcare provider informed about any changes in your health status, medications, or if you plan to become pregnant or are breastfeeding.
• Special Precautions: Inform healthcare providers, including dentists and emergency medical personnel, about your use of Rybelsus before any medical procedure or emergency treatment.
• Diet and Exercise: Continue following a healthy diet and exercise plan as recommended by your healthcare provider.

Always follow your healthcare provider’s instructions and guidelines for using Rybelsus. If you have any questions or concerns, consult your healthcare provider for personalized advice.