WARNING

Taking Vemlidy (tenofovir alafenamide) is generally considered safe and effective for the treatment of chronic hepatitis B virus (HBV) infection. However, like any medication, it is associated with certain risks and potential side effects. Here’s a brief overview of the risks associated with taking Vemlidy:

• Kidney Effects: While Vemlidy is associated with a lower risk of kidney side effects compared to some other medications containing tenofovir, it’s important to monitor kidney function during treatment.
• Bone Density Loss: Long-term use of tenofovir, the active ingredient in Vemlidy, has been associated with potential bone density loss. Regular monitoring and appropriate interventions may be considered.
• Liver Function: Vemlidy may cause changes in liver enzyme levels, but this does not necessarily indicate liver damage. Regular monitoring of liver function is typically part of the treatment plan.
• Common Side Effects: Common side effects include headache, fatigue, nausea, upper respiratory tract infection, abdominal pain, and back pain.
• Allergic Reactions: In rare cases, individuals may experience severe allergic reactions, such as difficulty breathing, swelling of the face, lips, tongue, or throat. Seek immediate medical attention if these symptoms occur.
• Lactic Acidosis: Although rare, tenofovir-containing medications have been associated with lactic acidosis, a serious condition that requires prompt medical attention. Symptoms may include weakness, unusual muscle pain, difficulty breathing, stomach pain with nausea and vomiting, and cold or blue hands and feet.
• Interaction with Other Medications: Vemlidy may interact with other medications, including over-the-counter drugs and herbal supplements. Inform your healthcare provider about all medications you are taking to avoid potential interactions.

It’s important to note that the benefits of Vemlidy in controlling hepatitis B and preventing liver damage generally outweigh the potential risks for most individuals. However, each person’s medical history and condition are unique, so it’s essential to discuss any concerns with your healthcare provider. They can provide personalized guidance based on your specific health status and help monitor for potential adverse effects during treatment.

Why is this medication prescribed?

Vemlidy (tenofovir alafenamide) is prescribed for the treatment of chronic hepatitis B virus (HBV) infection in adults and pediatric patients who are 12 years of age and older. Chronic hepatitis B is a viral infection that attacks the liver and can lead to serious complications, including liver damage, cirrhosis, and an increased risk of liver cancer.

Vemlidy belongs to a class of medications called nucleoside analogs. It works by inhibiting the replication of the hepatitis B virus, helping to reduce the amount of virus in the body and control the progression of the infection. While Vemlidy does not cure hepatitis B, it is an important tool in managing the disease and preventing associated complications.

The decision to prescribe Vemlidy is typically based on various factors, including the severity of the hepatitis B infection, the presence of liver damage, the patient’s overall health, and other individual considerations. Treatment goals include suppressing the virus, improving liver function, and reducing the risk of long-term complications.

How should this medicine be used?

Vemlidy (tenofovir alafenamide) is a prescription medication used to treat chronic hepatitis B virus (HBV) infection in adults and pediatric patients 12 years of age and older. Here are general guidelines on how Vemlidy is typically used, but it’s essential to follow your healthcare provider’s specific instructions:

• Dosage: The recommended dosage of Vemlidy can vary depending on factors such as the patient’s age and weight. Your healthcare provider will determine the appropriate dosage for you.
• Administration: Vemlidy is usually taken orally once daily with food. Taking it with food helps improve the absorption of the medication.
• Consistency: Try to take Vemlidy at the same time every day to maintain a consistent level of the medication in your body.
• Missed Dose: If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
• Monitoring: Regular monitoring of your hepatitis B virus levels and liver function is typically required during treatment. This helps your healthcare provider assess the effectiveness of the medication and adjust the treatment plan if necessary.
• Duration of Treatment: Vemlidy is not a cure for hepatitis B, so it is usually prescribed for a prolonged period to help control the infection and prevent liver damage. Follow your healthcare provider’s recommendations regarding the duration of treatment.
• Follow-up: Attend all scheduled follow-up appointments with your healthcare provider. These appointments are crucial for monitoring your progress, checking for potential side effects, and adjusting the treatment plan if needed.

It’s essential to communicate openly with your healthcare provider about any concerns or side effects you may be experiencing while taking Vemlidy. Do not stop taking the medication without consulting your healthcare provider, as stopping treatment prematurely could lead to a resurgence of the hepatitis B virus.

Always follow the specific instructions provided by your healthcare provider and refer to the medication’s official prescribing information or the patient information leaflet for detailed guidelines. If you have any questions or concerns about your medication, consult with your healthcare provider or pharmacist.

Other uses for this medicine

Vemlidy (tenofovir alafenamide) is primarily used for the treatment of chronic hepatitis B virus (HBV) infection. It is not typically prescribed for other medical conditions. However, medical information can change over time, and new uses for medications may have been identified since then. It’s crucial to consult with a healthcare professional or check the most recent medical literature and prescribing information for any updates.

What special precautions should I follow?

Regarding special precautions for Vemlidy, here are some general considerations. However, please note that these are guidelines, and individual circumstances may vary. Always follow the specific instructions provided by your healthcare provider:

• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Vemlidy during pregnancy and breastfeeding should be discussed with your healthcare provider, and they will weigh the potential benefits against any potential risks.
• Kidney Function: Vemlidy is associated with a lower risk of kidney side effects compared to some other medications containing tenofovir, but it is still essential to monitor kidney function regularly. Inform your healthcare provider if you have a history of kidney problems.
• Bone Health: Some antiretroviral medications, including those containing tenofovir, have been associated with bone density loss. Your healthcare provider may monitor your bone health and recommend supplements or lifestyle changes if needed.
• HIV Coinfection: If you have both HIV and HBV infections, discuss your treatment plan with your healthcare provider. Vemlidy is primarily indicated for HBV and may not be sufficient for treating HIV.
• Adherence to Treatment: It’s important to take Vemlidy exactly as prescribed and not to miss doses. This helps maintain effective drug levels in the body and reduces the risk of developing resistance to the medication.
• Regular Monitoring: Regular monitoring of liver function, HBV levels, kidney function, and other relevant parameters may be necessary during treatment. Attend all scheduled follow-up appointments with your healthcare provider.
• Drug Interactions: Inform your healthcare provider about all medications, including over-the-counter drugs, supplements, and herbal products, that you are taking. Some medications may interact with Vemlidy, affecting its efficacy or increasing the risk of side effects.

Always consult with your healthcare provider or pharmacist for personalized advice and to address any specific concerns or questions you may have about Vemlidy and its use in your individual case.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions for Vemlidy. However, taking the medication with food is recommended, as it can help improve its absorption. Follow your healthcare provider’s advice regarding dietary considerations, especially if there are specific concerns related to your overall health or other medical conditions.

What should I do if I forget a dose?

If you forget to take a dose of Vemlidy:

• Take it as soon as you remember.
• If it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to make up for a missed one.

If you have concerns about missed doses or if you are unsure about what to do, contact your healthcare provider for guidance.

What side effects can this medication cause?

Vemlidy (tenofovir alafenamide) may cause side effects, and it’s essential to be aware of these potential reactions. However, not everyone will experience these side effects, and some individuals may experience none at all. Common side effects of Vemlidy include:

• Headache: Mild to moderate headaches are reported by some individuals taking Vemlidy.
• Fatigue: Feeling tired or experiencing fatigue is a common side effect.
• Nausea: Some people may experience nausea or an upset stomach.
• Upper Respiratory Tract Infection: Symptoms such as a cough, sore throat, or nasal congestion may occur.
• Abdominal Pain: Discomfort or pain in the abdominal area may occur in some individuals.
• Back Pain: Some individuals may experience back pain.
• Dizziness: Feeling dizzy or lightheaded is reported in some cases.
• Elevated Liver Enzymes: Blood tests may reveal increased levels of liver enzymes, although this is not necessarily an indication of liver damage.
• Decreased Bone Density: Long-term use of tenofovir, the active ingredient in Vemlidy, has been associated with a potential decrease in bone mineral density.
• Renal (Kidney) Effects: While Vemlidy is associated with a lower risk of kidney side effects compared to some other medications containing tenofovir, kidney function should be monitored.

It’s important to note that this is not an exhaustive list of potential side effects, and individual reactions may vary. Additionally, serious side effects are possible but less common. If you experience any unusual or severe symptoms while taking Vemlidy, it’s crucial to contact your healthcare provider promptly.

Seek immediate medical attention if you experience signs of a serious reaction, such as severe allergic reactions (difficulty breathing, swelling of the face, lips, tongue, or throat) or lactic acidosis (symptoms may include weakness or being more tired than usual, unusual muscle pain, being short of breath or fast breathing, stomach pain with nausea and vomiting, cold or blue hands and feet).

As with any medication, it’s important to discuss any concerns or questions about side effects with your healthcare provider. They can provide personalized information based on your medical history and help determine the most appropriate course of action.

What should I know about storage and disposal of this medication?

Storage and Disposal of Vemlidy:

• Storage:
  • Store Vemlidy at room temperature, away from moisture and heat.
  • Keep the medication in its original container, and ensure that the container is tightly closed.
  • Do not store Vemlidy in the bathroom.
• Disposal:
  • Dispose of unused or expired Vemlidy in accordance with local regulations and guidelines.
  • Do not flush medications down the toilet or pour them into a drain unless specifically instructed to do so.
  • Consult with your pharmacist or local waste disposal facility for information on the proper disposal of medications.

In case of emergency/overdose

In case of an overdose or emergency, contact your local poison control center at 1-800-222-1222 (in the United States). If the person is unconscious, having difficulty breathing, or experiencing severe symptoms, call emergency services immediately.

What other information should I know?

• Regular Follow-Up: Attend all scheduled follow-up appointments with your healthcare provider to monitor your response to the medication and address any concerns.
• Medical and Laboratory Tests: Your healthcare provider may order regular blood tests to monitor liver function, kidney function, and other relevant parameters.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care, including dentists and specialists, that you are taking Vemlidy. This is important for proper coordination of your healthcare.
• Avoid Alcohol and Recreational Drugs: Discuss with your healthcare provider whether alcohol or certain recreational drugs may interact with Vemlidy, and follow their recommendations.
• Patient Assistance Programs: If you have difficulty affording your medication, inquire about patient assistance programs that may be available to provide financial assistance.
• Educate Yourself: Understand the importance of adherence to your prescribed treatment regimen. If you have questions about your medication or its effects, ask your healthcare provider or pharmacist.
• Travel Considerations: If you plan to travel, ensure that you have an adequate supply of medication. It may also be helpful to carry a list of your medications and their dosages.
• Keep a List of Medications: Maintain an up-to-date list of all medications, including prescription and over-the-counter drugs, as well as any supplements, and share this list with your healthcare provider.

Always follow the specific instructions provided by your healthcare provider and refer to the medication’s official prescribing information or the patient information leaflet for detailed guidelines. If you have any questions or concerns about your medication, consult with your healthcare provider or pharmacist.