Why is this medication prescribed?

Ilaris (generic name: canakinumab) is prescribed for its anti-inflammatory properties. It is primarily used to treat several inflammatory conditions that are characterized by excessive activation of a protein called interleukin-1 beta (IL-1β) in the body. IL-1β is involved in the inflammatory response and plays a role in various inflammatory disorders.

Ilaris is prescribed for the following conditions:

• Cryopyrin-associated periodic syndromes (CAPS): CAPS is a group of rare genetic disorders characterized by overproduction of IL-1β, leading to recurrent episodes of inflammation. Ilaris helps inhibit the action of IL-1β, thereby reducing the frequency and severity of symptoms such as fever, rash, joint pain, and systemic inflammation.
• Systemic juvenile idiopathic arthritis (SJIA): SJIA is a form of juvenile arthritis that involves systemic inflammation. Ilaris is used to treat SJIA by targeting the IL-1β pathway, which plays a role in the disease. It helps reduce inflammation, fever, and other symptoms associated with SJIA.
• Tumor necrosis factor receptor-associated periodic syndrome (TRAPS): TRAPS is a rare autoinflammatory disorder caused by mutations in the tumor necrosis factor (TNF) receptor. Ilaris is prescribed to treat TRAPS by inhibiting IL-1β, which is involved in the inflammatory response seen in this condition.

How should this medicine be used?

Ilaris (generic name: canakinumab) is a medication that is used to treat certain inflammatory conditions. It is typically administered as an injection under the skin (subcutaneous injection) by a healthcare professional. The specific dosage and frequency of administration will depend on the condition being treated and the individual’s response to the medication.

Ilaris is primarily used for the treatment of certain autoinflammatory diseases, such as cryopyrin-associated periodic syndromes (CAPS), including familial cold autoinflammatory syndrome (FCAS) and Muckle-Wells syndrome (MWS). It can also be used to treat systemic juvenile idiopathic arthritis (SJIA) in children and adults who have not responded well to other treatments.

It’s important to note that Ilaris should only be used under the supervision of a healthcare professional who has experience with the treatment of these conditions. The dosage and duration of treatment should be determined by the healthcare provider based on the individual patient’s needs.

Other uses for this medicine

Ilaris (canakinumab) is primarily approved for the treatment of cryopyrin-associated periodic syndromes (CAPS), systemic juvenile idiopathic arthritis (SJIA), and tumor necrosis factor receptor-associated periodic syndrome (TRAPS). However, there may be off-label or investigational uses of Ilaris that are not officially approved but are prescribed by healthcare providers based on their clinical judgment and available evidence.

What special precautions should I follow?

Some potential off-label uses of Ilaris that are being explored include the treatment of certain autoinflammatory diseases, such as adult-onset Still’s disease and Schnitzler syndrome. However, it’s important to note that the use of Ilaris for these conditions is not yet fully established and should be discussed with a healthcare professional.

Special precautions associated with the use of Ilaris include:

• Infections: Ilaris can weaken the immune system, increasing the risk of infections. Before starting Ilaris, inform your healthcare provider if you have any active infections or a history of recurrent infections. It is important to promptly report any signs of infection while using Ilaris, such as fever, cough, sore throat, or other symptoms.
• Allergic Reactions: Some individuals may experience allergic reactions to Ilaris. Inform your healthcare provider if you have a known allergy to canakinumab or any other components of the medication. Seek immediate medical attention if you develop signs of an allergic reaction, including difficulty breathing, swelling, rash, or itching.
• Vaccinations: It is recommended to complete all necessary vaccinations before starting Ilaris, as the medication may interfere with the effectiveness of certain vaccines. Discuss with your healthcare provider which vaccinations are appropriate for you.
• Live Vaccines: The use of live vaccines is generally not recommended while on Ilaris due to the potential risk of infection. Consult your healthcare provider for guidance on vaccinations if you are receiving Ilaris.
• Pregnancy and Breastfeeding: The safety of Ilaris during pregnancy and breastfeeding has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Ilaris with your healthcare provider.
• Monitoring: Regular monitoring of your condition and laboratory tests may be necessary while using Ilaris to ensure its effectiveness and to detect any potential side effects.

These precautions are not exhaustive, and it is crucial to consult with your healthcare provider for a comprehensive understanding of the precautions and considerations specific to your individual situation when using Ilaris.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Ilaris. However, it is always advisable to follow a healthy and balanced diet as recommended by your healthcare provider. It’s a good idea to maintain a diet that includes a variety of fruits, vegetables, whole grains, lean proteins, and healthy fats.

What should I do if I forget a dose?

If you forget to take a dose of Ilaris, it is important to contact your healthcare provider or pharmacist for guidance. They will be able to provide you with the best advice based on your specific situation. It’s generally recommended to take the missed dose as soon as you remember, as long as it is not too close to the time of your next scheduled dose. Do not double the dose to make up for a missed one unless directed by your healthcare provider.

What side effects can this medication cause?

Ilaris (canakinumab) is a medication that can have potential side effects. It’s important to note that not everyone experiences side effects, and the severity and frequency of side effects can vary from person to person. Common side effects of Ilaris may include:

• Injection site reactions: This can include redness, swelling, pain, or itching at the site where the medication is injected.
• Upper respiratory tract infections: These may include symptoms such as a runny nose, sore throat, cough, or sinus congestion.
• Diarrhea: Some individuals may experience episodes of loose or watery stools.
• Headache: This is a common side effect reported by some individuals taking Ilaris.
• Nausea: Some people may experience a feeling of discomfort or queasiness in the stomach.
• Abdominal pain: This can range from mild discomfort to more severe pain in the abdominal area.
• Rash or skin reactions: It is possible to experience skin-related side effects, such as a rash or itching.
• Urinary tract infections: Some individuals may be at an increased risk of developing urinary tract infections.
• Increased risk of infections: Ilaris works by suppressing the immune system, which can increase the risk of infections. It is important to report any signs of infection, such as fever, sore throat, or unusual tiredness, to your healthcare provider.

It’s important to remember that this is not an exhaustive list of side effects, and other rare or severe side effects may occur. If you experience any persistent or bothersome side effects while taking Ilaris, it is crucial to inform your healthcare provider as soon as possible. They can provide further guidance and determine the best course of action based on your specific situation.

What should I know about storage and disposal of this medication?

• Storage: Ilaris should be stored in the refrigerator at a temperature between 2°C and 8°C (36°F and 46°F). Do not freeze the medication. Keep it in its original packaging or carton until ready for use to protect it from light. Do not shake the vial.
• Handling: It is important to follow proper handling procedures when preparing and administering Ilaris. If you are not familiar with the proper technique, consult your healthcare provider or pharmacist for instructions.
• Disposal: Dispose of unused or expired Ilaris in accordance with local regulations and guidelines. Do not throw it in the regular trash or flush it down the toilet. Contact your healthcare provider or local waste disposal authority for information on how to safely dispose of the medication.

In case of emergency/overdose

If you believe you have experienced an overdose or are having a severe reaction to Ilaris, it is crucial to seek immediate medical assistance or contact your local emergency services. In such situations, it is helpful to provide healthcare professionals with information about the medication, dosage, and any other relevant details.

What other information should I know?

• Precautions: Inform your healthcare provider about any allergies or medical conditions you have before starting Ilaris. It is also essential to disclose all the medications you are currently taking, including over-the-counter drugs, supplements, and herbal products.
• Monitoring: Regular monitoring and follow-up visits with your healthcare provider are necessary to assess the effectiveness of the medication and monitor for any potential side effects.
• Vaccinations: It is generally recommended to complete all recommended vaccinations before starting treatment with Ilaris. However, live vaccines should be avoided while on Ilaris due to the potential risk of infection.
• Pregnancy and breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of Ilaris during pregnancy or breastfeeding should be discussed with your healthcare provider, weighing the potential benefits against the risks.
• Medication interactions: Ilaris may interact with certain medications, including immunosuppressive drugs. Inform your healthcare provider about all the medications you are taking to avoid any potential interactions.

Remember, it is important to follow your healthcare provider’s instructions and guidelines for the safe and effective use of Ilaris. They will provide you with personalized advice and information based on your specific medical condition and treatment plan.