WARNING

Jadenu, also known by its generic name deferasirox, is a medication used to treat chronic iron overload in patients who receive regular blood transfusions. While Jadenu can be effective in managing iron overload, it is important to be aware of potential risks associated with its use. Here are some key risks:

• Gastrointestinal Effects: Jadenu can cause gastrointestinal side effects such as nausea, vomiting, abdominal pain, and diarrhea. These symptoms are usually mild to moderate but can be severe in some cases. Taking the medication with food or adjusting the dosage may help alleviate these effects.
• Kidney Problems: Rarely, Jadenu can lead to kidney problems, including acute kidney injury or a decline in kidney function. Regular monitoring of kidney function is essential during treatment, especially in patients with pre-existing kidney issues.
• Liver Damage: In rare cases, Jadenu can cause liver problems, including abnormal liver function tests and liver damage. Regular monitoring of liver function is important during treatment.
• Allergic Reactions: Some individuals may experience allergic reactions to Jadenu, which can manifest as rash, itching, swelling, dizziness, or difficulty breathing. If any of these symptoms occur, medical attention should be sought immediately.
• Auditory and Visual Effects: There have been reports of auditory and visual disturbances in some patients taking Jadenu. If any changes in hearing or vision occur, it is important to consult a healthcare professional.
• Pregnancy and Breastfeeding: Jadenu may pose risks to unborn babies, and its use during pregnancy should be carefully considered. It is also not recommended to breastfeed while taking Jadenu, as it can pass into breast milk.

It is crucial to consult with a healthcare professional before starting Jadenu to assess the potential risks and benefits based on your specific medical history and circumstances. Regular monitoring and communication with your healthcare provider throughout treatment can help mitigate risks and ensure safe and effective use of the medication.

Why is this medication prescribed?

Jadenu is prescribed for the treatment of chronic iron overload in patients who have conditions such as thalassemia syndromes and other chronic anemias. These conditions often require frequent blood transfusions, which can lead to an accumulation of excess iron in the body over time.

Iron overload can be harmful because the body has limited ways of eliminating excess iron. If left untreated, it can lead to complications such as liver damage, heart problems, and endocrine disorders.

Jadenu contains the active ingredient deferasirox, which is an iron chelator. It works by binding to the excess iron in the body and helping to remove it through urine and feces. By reducing iron levels, Jadenu helps to prevent or slow down the progression of iron overload-related complications.

How should this medicine be used?

Jadenu should be used according to the instructions provided by the prescribing healthcare professional. It is important to follow these instructions carefully to ensure the safe and effective use of the medication. Here are some general guidelines for using Jadenu:

• Dosage: The dosage of Jadenu can vary depending on factors such as the patient’s age, weight, and the severity of iron overload. The healthcare professional will determine the appropriate dosage for each individual.
• Administration: Jadenu is taken orally as tablets. The tablets should be swallowed whole and not crushed or chewed. It can be taken with or without food. However, taking it with a light meal may help reduce the chances of gastrointestinal side effects.
• Timing: Jadenu is usually taken once a day. It is recommended to take it at the same time each day to maintain a consistent level of the medication in the body.
• Compliance: It is important to take Jadenu regularly and as prescribed by the healthcare professional. Do not skip doses or stop taking the medication without consulting your doctor.
• Monitoring: During treatment with Jadenu, regular monitoring of iron levels and overall health is typically required. This may involve blood tests to assess iron levels, liver function, and kidney function.

It is crucial to consult with a healthcare professional or pharmacist for specific instructions tailored to your individual needs and to address any questions or concerns you may have about using Jadenu. They will provide detailed guidance based on your specific condition and treatment plan.

Other uses for this medicine

While Jadenu is primarily used for iron overload, there are no other approved uses for this medication. However, it’s essential to consult a healthcare professional or refer to the latest prescribing information to obtain the most up-to-date and accurate information regarding any off-label uses.

What special precautions should I follow?

Regarding precautions, it is crucial to follow your healthcare provider’s instructions and the medication’s prescribing information. Here are some general precautions associated with Jadenu:

• Allergies: Inform your doctor if you have any known allergies to deferasirox or any other medications.
• Medical history: Provide your healthcare provider with a comprehensive medical history, including any kidney or liver problems, bleeding disorders, gastrointestinal ulcers, or other significant medical conditions.
• Pregnancy and breastfeeding: Jadenu may have potential risks to a developing fetus or nursing infant. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Medication interactions: Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Some medications may interact with Jadenu, potentially affecting its effectiveness or increasing the risk of side effects.
• Renal and hepatic function monitoring: Regular monitoring of kidney and liver function is typically recommended while taking Jadenu. Your healthcare provider will advise you on the necessary tests and frequency.
• Side effects: Like any medication, Jadenu may cause side effects. Common side effects may include nausea, vomiting, diarrhea, abdominal pain, rash, and elevated liver enzyme levels. Report any persistent or severe side effects to your doctor.

It’s important to note that this information may not be exhaustive, and specific precautions may vary based on individual circumstances. Always consult your healthcare provider or refer to the medication’s prescribing information for detailed instructions and precautions related to your situation.

What special dietary instructions should I follow?

Take Jadenu on an empty stomach, at least 30 minutes before a meal. Avoid consuming food or drinks (except for water) for at least 2 hours before and after taking Jadenu. This is because food and certain beverages can affect the absorption of the medication. However, it’s important to follow your healthcare provider’s instructions regarding any specific dietary restrictions or modifications based on your individual needs.

What should I do if I forget a dose?

If you forget to take a dose of Jadenu, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Jadenu (deferasirox) is a medication used for the treatment of chronic iron overload caused by blood transfusions in patients with certain conditions like thalassemia or other anemias. While Jadenu can be effective in managing iron overload, it may also cause some side effects. Common side effects of Jadenu include:

• Gastrointestinal issues: Nausea, vomiting, diarrhea, abdominal pain, and indigestion are common side effects of Jadenu. Taking the medication with food or adjusting the dosage may help alleviate these symptoms.
• Skin rash: Some individuals may develop a rash or experience itching while taking Jadenu. If the rash becomes severe or is accompanied by other symptoms, medical attention should be sought.
• Headache: Jadenu may cause headaches in some people. These headaches are generally mild and go away on their own. If the headaches persist or worsen, it is advisable to consult a healthcare professional.
• Elevated liver enzymes: Jadenu can affect liver function, leading to elevated liver enzyme levels. Regular monitoring of liver function is necessary during treatment with Jadenu to ensure its safe use.
• Kidney problems: In rare cases, Jadenu has been associated with kidney problems, including kidney dysfunction and acute kidney injury. Regular monitoring of kidney function is important while taking this medication.
• Auditory and ocular disturbances: Some individuals may experience auditory disturbances such as hearing loss or ringing in the ears (tinnitus). Visual disturbances such as blurred vision or cataracts have also been reported.

It is important to note that not all individuals will experience these side effects, and some people may experience side effects not listed here. It is recommended to consult a healthcare professional or refer to the medication’s prescribing information for a comprehensive list of side effects and any precautions associated with Jadenu.

What should I know about storage and disposal of this medication?

Storage:

• Keep Jadenu tablets in their original blister pack until you are ready to take them.
• Store Jadenu at room temperature, away from moisture, heat, and direct sunlight.
• Keep the medication out of reach of children and pets.

Disposal:

• Do not dispose of Jadenu tablets in household trash or flush them down the toilet.
• Consult your local waste disposal regulations or community programs to determine the proper disposal method.
• You may also consult a pharmacist or healthcare provider for guidance on safe medication disposal.

In case of emergency/overdose

• If someone has taken an overdose of Jadenu or is experiencing severe symptoms, immediately call emergency services or go to the nearest emergency room.
• If possible, provide the healthcare professionals with information on the medication taken, dosage, and the time of ingestion.
• If you are experiencing mild symptoms or have questions about a possible overdose, contact your local poison control center or seek medical advice.

What other information should I know?

• Follow the dosage instructions provided by your healthcare provider. Do not change the dosage or stop taking Jadenu without consulting your doctor.
• Inform your doctor about any other medications, supplements, or herbal products you are taking, as they may interact with Jadenu.
• Before starting Jadenu, inform your healthcare provider about any pre-existing medical conditions or allergies you may have.
• While taking Jadenu, regular monitoring of blood counts, liver function, and kidney function may be necessary.
• Report any side effects or concerns to your doctor promptly.
• It is important to maintain a balanced diet and follow your doctor’s recommendations for managing iron overload.
• Store Jadenu away from other medications and keep it in a dry place.
• Always keep Jadenu in its original packaging to ensure proper identification and to protect it from moisture.
• If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Remember to consult your healthcare provider or pharmacist for personalized advice and further information specific to your situation.