Why is this medication prescribed?

Pralsetinib (brand name Gavreto) is a targeted therapy medication that is primarily prescribed for the treatment of certain types of cancer. It is specifically used in patients with advanced or metastatic non-small cell lung cancer (NSCLC) that has a specific genetic alteration known as a rearranged during transfection (RET) fusion or RET-mutant tumor.

Pralsetinib is a kinase inhibitor that works by blocking abnormal signaling pathways associated with the RET fusion or mutation, which can promote the growth and spread of cancer cells. By inhibiting these pathways, Pralsetinib helps to suppress tumor growth and can potentially lead to tumor shrinkage or stabilization.

How should this medicine be used?

The usage and dosage of Pralsetinib are typically determined by the prescribing healthcare professional, and it’s important to follow their instructions carefully. It is usually taken orally in the form of capsules, and the recommended dose may vary depending on individual factors such as the patient’s overall health, the specific cancer being treated, and other medications they may be taking.

Generally, Pralsetinib is taken once daily, with or without food. The capsules should be swallowed whole and not crushed or opened. If a dose is missed, it should be taken as soon as remembered, unless it is close to the time for the next scheduled dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed. It’s important not to take extra doses to make up for a missed one.

Other uses for this medicine

Pralsetinib (Gavreto) is primarily used for the treatment of advanced or metastatic non-small cell lung cancer (NSCLC) with a specific genetic alteration known as a rearranged during transfection (RET) fusion or RET-mutant tumor. However, it’s important to note that medication uses can evolve over time, and there may be new indications or research findings beyond my knowledge cutoff in September 2021. Therefore, it’s essential to consult with a healthcare professional or refer to the latest medical resources for the most up-to-date information on Pralsetinib’s uses.

What special precautions should I follow?

As for special precautions, it is crucial to follow the instructions provided by the prescribing healthcare professional and adhere to the recommended precautions. Here are some general precautions that may apply:

• Pregnancy and breastfeeding: Pralsetinib may cause harm to the developing fetus, so it is important to inform your doctor if you are pregnant or planning to become pregnant. Additionally, it is not recommended to breastfeed while taking Pralsetinib, as it may pass into breast milk and harm the nursing infant.
• Drug interactions: Pralsetinib may interact with other medications, including over-the-counter drugs, herbal supplements, and prescription medications. Inform your healthcare provider about all the medications you are currently taking to avoid any potential drug interactions.
• Liver and kidney function: Pralsetinib can affect liver and kidney function. Your healthcare provider may perform regular blood tests to monitor these functions. If you have pre-existing liver or kidney problems, it’s important to discuss this with your doctor before starting Pralsetinib.
• Bleeding risk: Pralsetinib may increase the risk of bleeding. Inform your healthcare provider if you have a history of bleeding disorders or are taking blood-thinning medications.
• QT prolongation: Pralsetinib has the potential to prolong the QT interval, which can lead to an irregular heart rhythm. Inform your doctor if you have a history of heart problems or any conditions that may predispose you to QT prolongation.
• Allergies: If you have known allergies or hypersensitivity reactions to Pralsetinib or any of its components, it is important to inform your healthcare provider before starting treatment.

What special dietary instructions should I follow?

When taking any medication, it is important to follow the instructions provided by your healthcare provider or the medication’s prescribing information. If you have been prescribed Pralsetinib, it’s crucial to consult with your doctor or pharmacist for specific dietary instructions and any potential interactions with food. They will be able to provide you with the most up-to-date and accurate information regarding the medication’s administration.

What should I do if I forget a dose?

In case you forget a dose of any medication, it’s generally recommended to take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, it’s advisable to skip the missed dose and resume your regular dosing schedule. It’s important not to take a double dose to make up for a missed one, as it can increase the risk of side effects.

What side effects can this medication cause?

Like any medication, Pralsetinib can have potential side effects. The specific side effects experienced by an individual may vary, and it’s important to consult with a healthcare professional for personalized information. That being said, here are some commonly reported side effects associated with Pralsetinib:

• High blood pressure (hypertension): Pralsetinib can cause an increase in blood pressure. Regular monitoring of blood pressure is usually recommended during treatment.
• Fatigue: Feeling tired or experiencing a lack of energy is a common side effect of Pralsetinib.
• Constipation: Some individuals may experience difficulty passing stools or have infrequent bowel movements while taking this medication.
• Decreased appetite: Pralsetinib can cause a decrease in appetite, which may lead to weight loss.
• Diarrhea: Some people may experience loose or watery stools while taking Pralsetinib.
• Nausea and vomiting: These gastrointestinal symptoms are possible side effects of the medication.
• Increased liver enzymes: Pralsetinib may lead to temporary elevations in liver enzyme levels, which are typically monitored during treatment.
• Changes in taste: Some individuals may notice alterations in their sense of taste or experience a metallic taste in their mouth.
• Peripheral edema: Swelling in the hands, feet, or ankles may occur as a side effect of Pralsetinib.
• Skin rash: Pralsetinib can cause skin reactions, including rashes or itching.

It’s important to note that not everyone will experience these side effects, and some individuals may experience additional or different reactions. It’s crucial to communicate any concerning symptoms to a healthcare professional who can provide guidance and support.

What should I know about storage and disposal of this medication?

Pralsetinib is a prescription medication used in the treatment of certain types of cancers, such as non-small cell lung cancer (NSCLC) or thyroid cancer, which have specific gene mutations. It is important to follow the specific instructions provided by your healthcare provider and the medication’s packaging. However, here are some general guidelines regarding the storage and disposal of Pralsetinib:

1. Storage:
   • Store Pralsetinib at room temperature, typically between 20°C and 25°C (68°F and 77°F).
   • Keep the medication in its original container, tightly closed to protect it from moisture.
   • Avoid exposing the medication to excessive heat or direct sunlight.
   • Keep it out of reach of children and pets.
2. Disposal:
   • It is important to dispose of Pralsetinib properly to prevent accidental ingestion or environmental contamination.
   • Do not dispose of the medication in household trash or flush it down the toilet unless specifically instructed to do so by local guidelines or a healthcare professional.
   • Contact your pharmacist or local waste disposal authority to inquire about proper medication disposal methods in your area.
   • They may provide specific instructions or direct you to a medication take-back program.

In case of emergency/overdose

In case of an emergency or overdose, it is crucial to seek immediate medical attention. Contact your local emergency services or go to the nearest emergency room. When contacting emergency services, provide them with detailed information about the medication, including its name (Pralsetinib), dosage strength, and the amount taken (if known).

What other information should I know?

Here are some additional points to consider:

• Inform your healthcare provider about any other medications, supplements, or herbal products you are taking, as they may interact with Pralsetinib.
• Inform your healthcare provider about any known allergies or sensitivities you have, especially to similar medications or ingredients.
• Attend regular follow-up appointments with your healthcare provider to monitor your progress and address any concerns or side effects.
• Adhere to the prescribed dosage and schedule. Do not alter or stop the medication without consulting your healthcare provider.
• Pralsetinib may cause certain side effects, such as nausea, fatigue, diarrhea, increased blood pressure, or changes in laboratory test results. Report any unexpected or severe side effects to your healthcare provider.

Please note that the information provided here is for general knowledge and should not replace the specific instructions and advice given by your healthcare provider.