Why is this medication prescribed?

Emapalumab-lzsg Injection is prescribed for the treatment of primary hemophagocytic lymphohistiocytosis (HLH) in pediatric and adult patients with refractory, recurrent, or progressive disease or intolerance with conventional HLH therapy. HLH is a life-threatening condition characterized by severe inflammation and tissue damage, particularly affecting the liver, spleen, and bone marrow.

Emapalumab-lzsg is a monoclonal antibody that works by blocking interferon-gamma (IFN-γ), a protein that plays a key role in the immune response. By inhibiting IFN-γ, emapalumab-lzsg helps to reduce the excessive inflammation and immune activation seen in HLH.

How should this medicine be used?

Emapalumab-lzsg Injection is typically administered under the supervision of a healthcare professional, such as a doctor or nurse, in a clinical setting like a hospital or outpatient clinic. Here are general guidelines on how it is used:

• Dosage: The dosage of emapalumab-lzsg Injection is determined by your healthcare provider based on factors such as your age, weight, medical condition, and response to treatment.
• Administration: Emapalumab-lzsg is administered as an intravenous infusion, which means it is injected directly into a vein. The infusion is usually given over a specified period of time, which can vary depending on factors like the dosage and individual patient needs.
• Preparation: The medication will be prepared by a healthcare professional prior to administration. They will follow specific guidelines for diluting the medication and ensuring proper handling to maintain its stability and effectiveness.
• Monitoring: While receiving emapalumab-lzsg Injection, you will be closely monitored by healthcare providers for any adverse reactions or changes in your condition. Vital signs such as blood pressure, heart rate, and temperature may be monitored during the infusion.
• Frequency: The frequency of emapalumab-lzsg injections will be determined by your healthcare provider based on your response to treatment and the recommended treatment regimen. It may be administered at regular intervals as part of ongoing therapy.
• Follow-Up: It’s important to attend all scheduled appointments for follow-up and monitoring while receiving emapalumab-lzsg Injection. Your healthcare provider may adjust your dosage or treatment plan based on your progress and any changes in your condition.

Always follow the instructions provided by your healthcare provider regarding the administration of emapalumab-lzsg Injection. Do not attempt to adjust the dosage or frequency of administration without consulting your healthcare provider first. If you have any questions or concerns about your treatment, be sure to discuss them with your healthcare provider.

Other uses for this medicine

Emapalumab-lzsg Injection is primarily used for the treatment of primary hemophagocytic lymphohistiocytosis (HLH). However, it’s essential to note that this medication should only be used under the supervision of a healthcare professional and for the specific condition it is prescribed for. Using it for other conditions without proper medical guidance can be dangerous and ineffective.

What special precautions should I follow?

As for special precautions, here are some important points to consider when using emapalumab-lzsg Injection:

• Allergies: Inform your healthcare provider if you have any allergies to emapalumab-lzsg or any other medications. This medication may contain inactive ingredients that can cause allergic reactions or other problems.
• Medical History: Provide your healthcare provider with your complete medical history, including any past or current medical conditions, especially if you have a history of infections or immune system disorders.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of emapalumab-lzsg during pregnancy or breastfeeding should be carefully weighed against potential risks and benefits.
• Infections: Emapalumab-lzsg works by suppressing the immune system, which can increase the risk of infections. Inform your healthcare provider if you develop any signs of infection, such as fever, chills, sore throat, or cough.
• Vaccinations: Avoid live vaccines while receiving emapalumab-lzsg treatment, as they may not be as effective and can pose a risk of infection. Discuss any vaccination schedules with your healthcare provider.
• Monitoring: Your healthcare provider will monitor your response to treatment and may perform regular blood tests to check for any changes in your condition or potential side effects.
• Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking, as they may interact with emapalumab-lzsg.
• Storage: Store emapalumab-lzsg Injection as directed by your healthcare provider or pharmacist. Follow the instructions provided on the product label regarding storage and disposal.

It’s essential to follow your healthcare provider’s instructions carefully when using emapalumab-lzsg Injection and to report any unusual symptoms or side effects promptly. Always consult with your healthcare provider if you have any questions or concerns about your treatment.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are no specific dietary restrictions associated with emapalumab-lzsg Injection. However, maintaining a balanced and healthy diet can support overall health and well-being during treatment.

What should I do if I forget a dose?

If you forget a dose of emapalumab-lzsg Injection, contact your healthcare provider or follow their instructions on what to do. It’s essential to adhere to the prescribed dosing schedule to ensure the effectiveness of the treatment. Avoid doubling the dose to make up for a missed one unless instructed to do so by your healthcare provider.

What side effects can this medication cause?

Emapalumab-lzsg Injection, like any medication, can cause side effects, although not everyone may experience them. Common side effects associated with emapalumab-lzsg Injection may include:

• Infusion-related reactions: Such as fever, chills, flushing, headache, nausea, vomiting, rash, itching, or breathing difficulties during or shortly after the infusion. These reactions typically occur during the first few doses and may decrease with subsequent infusions.
• Infections: Emapalumab-lzsg suppresses the immune system, which can increase the risk of infections. Patients may experience respiratory infections, urinary tract infections, or other types of infections.
• Liver function abnormalities: Changes in liver function tests may occur, including elevated liver enzymes (transaminases) or bilirubin levels.
• Decreased blood cell counts: Emapalumab-lzsg may cause decreases in certain types of blood cells, including red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia).
• Hypersensitivity reactions: Rarely, severe allergic reactions may occur, including anaphylaxis, which requires immediate medical attention.
• Other side effects: Additional side effects may include diarrhea, abdominal pain, fatigue, dizziness, or changes in blood pressure.

It’s important to report any side effects or adverse reactions to your healthcare provider promptly. They can provide guidance on managing side effects and may adjust your treatment regimen if necessary. Additionally, if you experience any severe or concerning symptoms, seek medical attention immediately.

This list of side effects is not exhaustive, and other side effects may occur. Always consult with your healthcare provider or pharmacist for more information on the potential side effects of emapalumab-lzsg Injection.

What should I know about storage and disposal of this medication?

Storage and disposal instructions for ElzoEmapalumab-lzsg Injectionnris:

• Storage: Emapalumab-lzsg Injection should be stored as directed by your healthcare provider or pharmacist. Typically, it is stored in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F). Do not freeze. Keep the medication in its original carton to protect it from light. Do not shake the vial.
• Disposal: Dispose of any unused or expired emapalumab-lzsg Injection as instructed by your healthcare provider or pharmacist. Follow any local regulations regarding the disposal of medications.

In case of emergency/overdose

In case of emergency or overdose of Emapalumab-lzsg Injection:

• Seek Medical Attention: If you suspect an overdose or experience severe adverse reactions, such as difficulty breathing, severe allergic reactions, or other serious symptoms, seek immediate medical attention or call emergency services.
• Poison Control: You can also contact your local poison control center for guidance on what to do in case of an overdose.

What other information should I know?

• Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider for monitoring and assessment of your condition.
• Blood Tests: Your healthcare provider may perform regular blood tests to monitor your response to treatment and detect any potential side effects.
• Medication Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with emapalumab-lzsg Injection.
• Pregnancy and Breastfeeding: Discuss the risks and benefits of emapalumab-lzsg Injection if you are pregnant, planning to become pregnant, or breastfeeding.
• Patient Education: It’s important to understand how to properly administer emapalumab-lzsg Injection and any potential side effects or precautions associated with the medication. Ask your healthcare provider or pharmacist if you have any questions or concerns.

Always follow the instructions provided by your healthcare provider or pharmacist regarding the storage, administration, and disposal of emapalumab-lzsg Injection, and contact them if you have any questions or need further information.