Why is this medication prescribed?

Darolutamide is a medication used to treat prostate cancer. It belongs to a class of drugs known as androgen receptor inhibitors. Prostate cancer cells depend on androgens (male hormones) to grow and spread. Darolutamide works by blocking the effects of androgens, thereby slowing down the growth and spread of prostate cancer cells.

It is typically prescribed for the treatment of non-metastatic castration-resistant prostate cancer (NM-CRPC). This means it’s used for prostate cancer that has not spread to other parts of the body and is no longer responding to hormone therapy (castration-resistant).

How should this medicine be used?

Darolutamide is typically taken orally in the form of tablets. Here’s a general guideline on how Darolutamide should be used:

• Dosage: The dosage of Darolutamide will be prescribed by your doctor based on factors such as your medical condition, response to treatment, and any other medications you may be taking.
• Frequency: Darolutamide is usually taken twice daily, approximately every 12 hours. It’s important to take it consistently at the same times each day to maintain steady levels of the medication in your body.
• Administration: Take Darolutamide with food. This helps improve its absorption and reduces the risk of gastrointestinal side effects. Swallow the tablets whole with a glass of water; do not crush, chew, or break them.
• Duration: Continue taking Darolutamide for as long as your doctor prescribes it, even if you feel well. Do not stop taking the medication without consulting your doctor first, as stopping suddenly may worsen your condition.
• Missed Dose: If you miss a dose of Darolutamide, take it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
• Storage: Store Darolutamide tablets at room temperature away from light and moisture. Keep them out of reach of children and pets.

Always follow your doctor’s instructions and any guidance provided on the medication label or by your pharmacist. If you have any questions or concerns about how to use Darolutamide, don’t hesitate to consult your healthcare provider or pharmacist for personalized advice.

Other uses for this medicine

Darolutamide is primarily used for the treatment of non-metastatic castration-resistant prostate cancer (NM-CRPC). However, there are no other approved medical uses for Darolutamide beyond this indication.

What special precautions should I follow?

As for special precautions, here are some important considerations to keep in mind when taking Darolutamide:

• Pregnancy and breastfeeding: Darolutamide may cause harm to an unborn baby if used during pregnancy. Therefore, it is essential to avoid becoming pregnant while taking Darolutamide. Additionally, it is not known whether Darolutamide passes into breast milk, so breastfeeding is not recommended during treatment.
• Liver function: Darolutamide can affect liver function. Your doctor may perform blood tests to monitor your liver function regularly while you are taking Darolutamide. Inform your doctor immediately if you experience symptoms of liver problems, such as yellowing of the skin or eyes, dark urine, or persistent nausea or vomiting.
• Allergies: Inform your doctor about any allergies you have, especially if you have a known allergy to Darolutamide or any of its ingredients.
• Drug interactions: Before taking Darolutamide, inform your doctor about all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Darolutamide may interact with certain medications, potentially increasing the risk of side effects or affecting the effectiveness of either medication.
• Driving and operating machinery: Darolutamide may cause dizziness or fatigue, which could impair your ability to drive or operate machinery safely. Exercise caution until you know how Darolutamide affects you.
• Other medical conditions: Inform your doctor about any other medical conditions you have, especially if you have a history of liver problems, seizures, or any other serious medical conditions.

Always follow your doctor’s instructions and advice regarding the use of Darolutamide. If you have any questions or concerns about special precautions or any aspect of your treatment, don’t hesitate to discuss them with your healthcare provider.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Darolutamide. However, it is generally recommended to take Darolutamide with food to improve its absorption and reduce the risk of gastrointestinal side effects.

What should I do if I forget a dose?

If you forget to take a dose of Darolutamide, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up. If you have any concerns about missed doses or need further guidance, consult your healthcare provider or pharmacist.

What side effects can this medication cause?

Darolutamide, like any medication, can cause side effects. Here are some potential side effects associated with Darolutamide:

• Fatigue: Feeling tired or weak is a common side effect of Darolutamide.
• Back pain: Some individuals may experience back pain while taking Darolutamide.
• Bone fractures: There is a risk of bone fractures, particularly in individuals with pre-existing osteoporosis or osteopenia.
• Hot flashes: Fluctuations in body temperature, often manifesting as sudden feelings of warmth, can occur.
• High blood pressure: Darolutamide may lead to elevated blood pressure in some individuals.
• Decreased appetite: Some people may experience a reduced desire to eat while taking Darolutamide.
• Rash: Skin reactions such as rashes or itching can occur.
• Nausea: Feeling sick to your stomach or experiencing stomach discomfort is possible.
• Diarrhea: Some individuals may develop diarrhea while taking Darolutamide.
• Peripheral edema: Swelling in the extremities, such as the hands or feet, can occur.
• Urinary tract infections: There is a risk of developing urinary tract infections while taking Darolutamide.
• Liver problems: Darolutamide can affect liver function, leading to liver problems in some individuals. Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, or persistent nausea or vomiting.
• Seizures: Although rare, Darolutamide may increase the risk of seizures in susceptible individuals.

It’s essential to report any side effects you experience while taking Darolutamide to your healthcare provider. They can provide guidance on managing side effects and may adjust your treatment plan if necessary. Additionally, some side effects may require immediate medical attention, so it’s crucial to seek help if you experience severe or concerning symptoms.

What should I know about storage and disposal of this medication?

Storage and disposal of Darifenacin:

• Storage:
  • Store Darolutamide tablets at room temperature, away from light and moisture.
  • Keep Darolutamide out of reach of children and pets.
  • Do not store Darolutamide in the bathroom, as moisture and humidity can affect its stability.
  • Follow any specific storage instructions provided by your pharmacist or on the medication label.
• Disposal:
  • Dispose of Darolutamide tablets properly as per local regulations or guidelines.
  • Do not flush Darolutamide down the toilet or pour it into a drain unless instructed to do so.
  • Consult your pharmacist or local waste disposal authority for information on how to safely dispose of unused or expired Darolutamide tablets.

In case of emergency/overdose

• In case of an overdose of Darolutamide, seek emergency medical attention or contact your local poison control center immediately.
• Symptoms of overdose may include severe dizziness, fainting, or difficulty breathing.
• Be prepared to provide information about the amount of Darolutamide ingested, as well as any other relevant details about the situation.

What other information should I know?

• Keep all appointments with your doctor and laboratory while taking Darolutamide. Your doctor will monitor your progress and check for any side effects.
• It’s essential to inform all healthcare providers involved in your care that you are taking Darolutamide, including dentists, surgeons, and emergency room personnel.
• Do not share Darolutamide with others, even if they have a similar condition. It is prescribed specifically for you based on your medical history and current health status.
• If you are scheduled for any surgery or dental procedure, inform your healthcare provider that you are taking Darolutamide.
• Carry a medical identification card or wear a medical alert bracelet to let emergency personnel know that you are taking Darolutamide.
• Continue taking Darolutamide as prescribed by your doctor, even if you feel well. Do not stop taking the medication without consulting your doctor first.
• If you have any questions or concerns about Darolutamide or your treatment plan, don’t hesitate to discuss them with your healthcare provider or pharmacist.

Following these guidelines will help ensure the safe and effective use of Darolutamide and minimize any potential risks associated with the medication.