Why is this medication prescribed?

Dacomitinib is a medication primarily prescribed for the treatment of non-small cell lung cancer (NSCLC) that has certain genetic mutations, such as EGFR (epidermal growth factor receptor) mutations. It belongs to a class of medications called tyrosine kinase inhibitors (TKIs), which work by blocking specific proteins in cancer cells to slow down or stop their growth. Dacomitinib is often used when other treatments have not been effective or when the cancer has progressed. It’s typically prescribed under the guidance of an oncologist who specializes in treating lung cancer.

How should this medicine be used?

Dacomitinib is typically taken orally in the form of tablets. Here are some general guidelines on how it should be used:

• Dosage: The dosage of Dacomitinib can vary depending on factors such as the patient’s body weight, overall health, and the stage of their cancer. It’s important for patients to follow their healthcare provider’s prescribed dosage exactly.
• Timing: Dacomitinib is usually taken once daily, with or without food. Patients should try to take it at the same time each day to maintain a consistent level of the medication in their body.
• Swallowing tablets: Dacomitinib tablets should be swallowed whole with a glass of water. Patients should not crush, chew, or break the tablets before swallowing them.
• Avoiding missed doses: If a patient misses a dose of Dacomitinib, they should take it as soon as they remember, unless it’s close to the time for their next scheduled dose. In that case, they should skip the missed dose and continue with their regular dosing schedule. Patients should not take extra doses to make up for a missed one.
• Duration of treatment: The duration of Dacomitinib treatment can vary depending on how well the patient responds to the medication and any side effects they may experience. Patients should continue taking Dacomitinib for as long as their healthcare provider recommends, even if they start to feel better.
• Monitoring: Patients taking Dacomitinib will likely need regular check-ups and monitoring by their healthcare provider to assess their response to the medication and monitor for any side effects.

It’s important for patients to follow their healthcare provider’s instructions carefully when taking Dacomitinib and to inform them of any side effects or concerns they may have. Additionally, patients should not adjust their dosage or stop taking Dacomitinib without consulting their healthcare provider first.

Other uses for this medicine

Other uses for Dacomitinib may include its investigation in clinical trials for other types of cancer or conditions. However, its primary approved use is for the treatment of metastatic NSCLC.

What special precautions should I follow?

As with any medication, there are special precautions to be aware of when using Dacomitinib:

• Pregnancy and Breastfeeding: Dacomitinib can cause harm to an unborn baby if used during pregnancy. It is important to use effective birth control while taking this medication and to avoid becoming pregnant during treatment. It is not known if Dacomitinib passes into breast milk, so breastfeeding is not recommended while taking this medication.
• Liver Function: Dacomitinib can affect liver function. Your doctor may perform blood tests to monitor your liver function regularly during treatment.
• Drug Interactions: Dacomitinib may interact with other medications, including over-the-counter drugs and herbal supplements. Inform your doctor about all medications you are taking to avoid potential interactions.
• Side Effects: Like all medications, Dacomitinib can cause side effects. Common side effects may include diarrhea, rash, mouth sores, decreased appetite, and fatigue. Contact your doctor if you experience severe or persistent side effects.
• Allergic Reactions: Some people may be allergic to Dacomitinib. Seek medical attention immediately if you experience symptoms of an allergic reaction, such as rash, itching, swelling, dizziness, or difficulty breathing.

Always discuss any questions or concerns you have about Dacomitinib with your doctor or healthcare provider. They can provide personalized advice based on your medical history and individual circumstances.

What special dietary instructions should I follow?

As for special dietary instructions, there are no specific dietary restrictions associated with Dacomitinib. However, maintaining a healthy and balanced diet is always important during cancer treatment to support overall well-being and optimize treatment outcomes. If you have any concerns about your diet while taking Dacomitinib, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget to take a dose of Dacomitinib, take it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take extra doses to make up for a missed one. If you have questions or concerns about missed doses, consult your healthcare provider for guidance.

What side effects can this medication cause?

Dacomitinib, like many medications, can cause side effects. Not everyone will experience these side effects, and their severity can vary from person to person. Some common side effects of Dacomitinib include:

• Diarrhea: This is one of the most common side effects of Dacomitinib. It can range from mild to severe. Drinking plenty of fluids and avoiding spicy or high-fiber foods may help manage diarrhea.
• Skin rash and acne: Many people develop a rash or acne while taking Dacomitinib. This can vary from a mild rash to more severe skin reactions. Using gentle skincare products and avoiding prolonged sun exposure can help manage these side effects.
• Dry skin: Dacomitinib can cause dryness and itching of the skin. Moisturizing regularly and using mild, fragrance-free skincare products can help alleviate these symptoms.
• Fatigue: Feeling tired or fatigued is a common side effect of Dacomitinib. Getting plenty of rest and conserving energy when needed can help manage fatigue.
• Decreased appetite and weight loss: Some people may experience a decrease in appetite and unintentional weight loss while taking Dacomitinib. Eating smaller, more frequent meals and focusing on nutrient-rich foods can help maintain a healthy weight.
• Mouth sores: Dacomitinib can sometimes cause mouth sores or ulcers. Practicing good oral hygiene and avoiding spicy or acidic foods may help prevent or reduce mouth sores.
• Nail changes: Dacomitinib may cause changes to the nails, such as brittleness or discoloration. Keeping the nails trimmed and moisturized can help minimize discomfort.
• Digestive issues: In addition to diarrhea, Dacomitinib may cause other digestive issues such as nausea, vomiting, and abdominal pain. Eating small, bland meals and avoiding trigger foods may help manage these symptoms.

It’s important to report any side effects you experience while taking Dacomitinib to your healthcare provider. They can provide guidance on managing side effects and may adjust your treatment plan if needed. Additionally, if you experience severe or persistent side effects, seek medical attention promptly.

What should I know about storage and disposal of this medication?

Storage and disposal of Dacomitinib:

Storage:

• Room temperature: Store Dacomitinib tablets at room temperature away from light and moisture.
• Keep out of reach of children: Store the medication in a safe place out of reach of children and pets.
• Original container: Keep Dacomitinib in its original container, tightly closed, to protect it from moisture and air.
• Avoid extreme temperatures: Do not store Dacomitinib in the refrigerator or freezer, and avoid exposing it to extreme heat or cold.

Disposal:

• Do not flush: Do not flush Dacomitinib tablets down the toilet or pour them down the drain unless instructed to do so by your healthcare provider or pharmacist.
• Dispose of properly: Follow any specific disposal instructions provided by your healthcare provider or pharmacist. You can also check with your local pharmacy or waste management authority for guidance on how to dispose of unused medications.

In case of emergency/overdose

• Seek medical help: In case of emergency or suspected overdose, call your local emergency services or go to the nearest emergency room immediately.
• Symptom management: If you or someone else has taken too much Dacomitinib and is experiencing symptoms such as severe diarrhea, vomiting, or dizziness, seek medical attention promptly.

What other information should I know?

• Regular monitoring: Your healthcare provider will likely monitor your condition and perform regular blood tests to check your response to Dacomitinib and monitor for any potential side effects.
• Follow-up appointments: Attend all scheduled follow-up appointments with your healthcare provider to monitor your progress and discuss any concerns or changes in your condition.
• Medication interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Dacomitinib can interact with certain medications.
• Patient support: Consider joining a support group for cancer patients or seeking counseling to help cope with the emotional and psychological aspects of living with cancer and undergoing treatment.

Always follow your healthcare provider’s instructions and guidance regarding the use, storage, and disposal of Dacomitinib, and do not hesitate to reach out if you have any questions or concerns.