Why is this medication prescribed?

Cabotegravir and Rilpivirine Injections are prescribed for the treatment of HIV-1 infection in adults who have achieved viral suppression with their current antiretroviral therapy (ART). These injections offer an alternative to daily oral medication, providing convenience and potentially improving medication adherence. They are typically recommended for individuals who have been on a stable regimen of oral ART for at least six months and have no history of treatment failure. The goal of this treatment is to maintain viral suppression, reduce the risk of HIV transmission, and improve the quality of life for people living with HIV.

How should this medicine be used?

Cabotegravir and Rilpivirine Injections are administered as a once-monthly treatment for HIV-1 infection in adults who have already achieved viral suppression with oral antiretroviral therapy (ART). Here’s how they should be used:

• Administration: The injections are typically administered by a healthcare professional into the muscle of the buttocks (gluteal region).
• Dosage: The standard dosage is one injection of Cabotegravir and Rilpivirine once every month. It’s crucial to adhere to the prescribed dosage schedule and not miss any appointments for injections.
• Stable ART: Before initiating treatment with Cabotegravir and Rilpivirine Injections, patients should have been on a stable regimen of oral ART for at least six months and have achieved viral suppression.
• Injection Site: The injection should be given into the muscle and not into a vein. Healthcare providers are trained to administer injections safely and effectively.
• Monitoring: Patients should continue to be monitored by their healthcare provider regularly to assess the effectiveness of the treatment, monitor for any side effects, and ensure viral suppression is maintained.
• Consultation: Patients should consult their healthcare provider for specific instructions tailored to their individual condition, including any adjustments to their treatment regimen or precautions to take.

It’s important for individuals receiving Cabotegravir and Rilpivirine Injections to follow their healthcare provider’s guidance closely and attend all scheduled appointments for injections to ensure the effectiveness of the treatment in maintaining viral suppression and managing HIV infection.

Other uses for this medicine

Cabotegravir and Rilpivirine Injections are primarily used for the treatment of HIV-1 infection in adults who have achieved viral suppression with oral antiretroviral therapy (ART). However, they may also have potential off-label uses or investigational uses in certain situations, though these would need to be discussed with a healthcare provider.

What special precautions should I follow?

Regarding special precautions for Cabotegravir and Rilpivirine Injections, here are some important points to consider:

• Allergies: Patients should inform their healthcare provider about any known allergies, especially if they have had a hypersensitivity reaction to any components of the injections.
• Medical History: Patients should disclose their complete medical history to their healthcare provider, including any history of liver or kidney problems, mental health conditions, or any other significant medical issues.
• Drug Interactions: Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking, as Cabotegravir and Rilpivirine Injections may interact with other drugs.
• Pregnancy and Breastfeeding: It’s important to discuss the risks and benefits of using Cabotegravir and Rilpivirine Injections during pregnancy or while breastfeeding. Healthcare providers can provide guidance based on individual circumstances.
• Injection Site Reactions: Patients should be aware of potential injection site reactions, such as pain, swelling, or redness, and report any concerning symptoms to their healthcare provider.
• Viral Resistance: As with any antiretroviral therapy, there is a risk of developing resistance to Cabotegravir and Rilpivirine if the medication is not taken as prescribed. Patients should adhere to the recommended dosing schedule and follow their healthcare provider’s instructions closely.
• Regular Monitoring: Patients should continue to be monitored regularly by their healthcare provider to assess the effectiveness of the treatment, monitor for any side effects or complications, and ensure viral suppression is maintained.

It’s important for patients to discuss any questions or concerns they have about Cabotegravir and Rilpivirine Injections with their healthcare provider to ensure safe and effective use of the medication.

What special dietary instructions should I follow?

• Food: Cabotegravir and Rilpivirine Injections can typically be taken with or without food. However, follow any specific dietary instructions provided by your healthcare provider.
• Alcohol: Limit alcohol consumption as excessive alcohol intake may exacerbate certain side effects or affect liver function.
• Grapefruit: Avoid consuming large amounts of grapefruit or grapefruit juice as it may interact with the medication.

What should I do if I forget a dose?

• Missed Appointment: If you miss a scheduled injection appointment, contact your healthcare provider as soon as possible to reschedule.
• Follow-up: It’s important to maintain the prescribed dosing schedule. Missing doses can affect treatment effectiveness and increase the risk of viral rebound.
• Next Dose: Resume your regular dosing schedule with the next scheduled injection. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Cabotegravir and rilpivirine injections, like any medication, can cause side effects. Common side effects may include:

• Injection site reactions: Pain, swelling, redness, or bruising at the injection site.
• Headache
• Fatigue
• Fever
• Nausea
• Diarrhea
• Rash
• Insomnia
• Muscle pain or weakness
• Dizziness

These side effects are usually mild to moderate and tend to improve over time as your body adjusts to the medication. However, if any of these side effects persist or worsen, it’s important to inform your healthcare provider.

In addition to the common side effects listed above, cabotegravir and rilpivirine injections may also cause more serious side effects in some individuals. These can include:

• Allergic reactions: Symptoms may include rash, itching, swelling of the face, lips, or tongue, difficulty breathing, or severe dizziness. Seek immediate medical attention if you experience any signs of an allergic reaction.
• Liver problems: Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, or unexplained fatigue. Contact your healthcare provider if you experience any symptoms of liver problems.
• Changes in mood or behavior: Some people may experience depression, anxiety, or other changes in mood or behavior while taking cabotegravir and rilpivirine. It’s important to discuss any concerns with your healthcare provider.

These are not all the possible side effects of cabotegravir and rilpivirine injections. If you experience any other symptoms that are bothersome or concerning, it’s essential to contact your healthcare provider for advice. Additionally, always follow your healthcare provider’s instructions for monitoring and managing side effects while taking this medication.

What should I know about storage and disposal of this medication?

Storage and disposal:

Storage:

• Store the injections in the original packaging at room temperature (between 68°F to 77°F or 20°C to 25°C).
• Keep the injections out of reach of children and pets.
• Protect the injections from light and moisture.
• Do not freeze the injections.
• Do not use the injections if they are discolored or contain particles.

Disposal:

• Dispose of any unused injections properly according to local regulations.
• Do not throw the injections in household trash or flush them down the toilet.
• Ask your healthcare provider or pharmacist about the proper disposal method in your area.

In case of emergency/overdose

• In case of an emergency or overdose, seek medical attention immediately.
• Contact your healthcare provider or local poison control center for guidance on what to do.
• Be prepared to provide information such as the amount of medication taken and any symptoms experienced.

What other information should I know?

• Follow the dosing schedule prescribed by your healthcare provider.
• Do not miss any scheduled appointments for injections.
• Inform your healthcare provider of any other medications or supplements you are taking, as they may interact with cabotegravir and rilpivirine.
• Report any side effects or concerns to your healthcare provider promptly.
• Continue to practice safe sex and take other precautions to prevent the transmission of HIV to others.
• Keep a record of your injections and any side effects experienced.
• Attend regular follow-up appointments with your healthcare provider for monitoring and management of your HIV infection.

It’s crucial to follow your healthcare provider’s instructions carefully and seek help promptly in case of any concerns or emergencies related to cabotegravir and rilpivirine injections.