Why is this medication prescribed?

Cabenuva is prescribed for the treatment of HIV-1 infection in adults who are virologically suppressed (HIV-1 RNA less than 50 copies per milliliter [mL]) on a stable regimen, with no history of treatment failure, and with no known or suspected resistance to the components of Cabenuva. Cabenuva is a combination of two long-acting injectable drugs: cabotegravir and rilpivirine.

Cabotegravir is an integrase strand transfer inhibitor (INSTI) and rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). The combination of these two drugs provides a convenient treatment option for individuals with HIV-1 infection who prefer a long-acting injectable regimen over daily oral medications.

How should this medicine be used?

Here’s how Cabenuva should be used:

• Administration: Cabenuva is administered as a once-monthly injection by a healthcare professional. Each injection consists of two separate injections given in different muscles: one injection of cabotegravir and one injection of rilpivirine.
• Initiation: Before starting Cabenuva, your healthcare provider will assess your HIV treatment history and current viral load. You must have already achieved viral suppression on a stable antiretroviral regimen before switching to Cabenuva.
• Dosing Schedule: Cabenuva is typically administered once a month, on the same day each month. Your healthcare provider will determine the appropriate dosing schedule for you.
• Injection Site: The injections are typically given in the buttocks (gluteal muscles). Your healthcare provider will rotate injection sites between the left and right buttocks with each dose to reduce the risk of injection site reactions.
• Monitoring: While on Cabenuva, your healthcare provider will monitor your viral load and overall health regularly to ensure that the treatment remains effective and to watch for any potential side effects.
• Missed Doses: It’s important not to miss any scheduled doses of Cabenuva. If you miss an appointment for your injection, contact your healthcare provider to reschedule as soon as possible. In some cases, your healthcare provider may need to provide additional doses or switch to an alternative treatment regimen.
• Combination Therapy: Cabenuva should be used in combination with other antiretroviral medications to effectively control HIV infection. Do not stop taking any of your other HIV medications unless directed by your healthcare provider.
• Patient Education: Make sure you understand how to properly store and dispose of Cabenuva injections. Follow your healthcare provider’s instructions carefully for storing the medication at home.

It’s important to follow your healthcare provider’s instructions closely while using Cabenuva to ensure that you receive the full benefit of the medication and to minimize the risk of complications or treatment failure. If you have any questions or concerns about how to use Cabenuva, don’t hesitate to discuss them with your healthcare provider.

Other uses for this medicine

Cabenuva is primarily indicated for the treatment of HIV-1 infection. It’s specifically designed for individuals who are virologically suppressed and want to switch from their current oral antiretroviral regimen to a long-acting injectable option for convenience and adherence reasons.

What special precautions should I follow?

Special Precautions for Cabenuva:

• Drug Interactions: Cabenuva may interact with other medications, including over-the-counter drugs, prescription medications, and herbal supplements. Inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.
• Hepatitis B Co-infection: If you have HIV-1 and hepatitis B virus (HBV) co-infection, your healthcare provider will closely monitor you during treatment with Cabenuva. Discontinuing treatment with Cabenuva may lead to a flare-up of hepatitis B. Your healthcare provider may need to adjust your treatment regimen accordingly.
• Injection Site Reactions: Injection site reactions, such as pain, swelling, or nodules, are common with Cabenuva. Inform your healthcare provider if you experience any persistent or severe reactions at the injection site.
• Allergic Reactions: Some individuals may experience allergic reactions to Cabenuva, which can be serious. Seek immediate medical attention if you develop signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing.
• Pregnancy and Breastfeeding: The safety of Cabenuva during pregnancy and breastfeeding is not well established. If you are pregnant or breastfeeding, discuss the risks and benefits of Cabenuva with your healthcare provider.
• Liver Function: Cabenuva may affect liver function. Your healthcare provider may perform regular liver function tests to monitor for any abnormalities.
• Mental Health: Some individuals may experience changes in mood or mental health while taking Cabenuva. Inform your healthcare provider if you experience symptoms such as depression, anxiety, or suicidal thoughts.
• Missed Doses: It’s important not to miss any scheduled doses of Cabenuva. Work closely with your healthcare provider to ensure timely administration of injections.

Always follow your healthcare provider’s instructions and guidance regarding the use of Cabenuva, including any special precautions specific to your medical history and condition.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Cabenuva. However, maintaining a healthy and balanced diet is important for overall health and well-being, especially when managing a chronic condition like HIV-1 infection. Be sure to follow any dietary recommendations provided by your healthcare provider or registered dietitian.

What should I do if I forget a dose?

If you forget a dose of Cabenuva, contact your healthcare provider as soon as possible to reschedule the missed dose. It’s crucial to maintain the monthly dosing schedule to ensure continued viral suppression and treatment effectiveness. Do not double the dose to make up for a missed one. Your healthcare provider can advise you on the best course of action based on your individual circumstances.

What side effects can this medication cause?

Cabenuva, which combines cabotegravir and rilpivirine, can cause various side effects. These side effects can vary in severity from person to person. Common side effects of Cabenuva may include:

• Injection site reactions: Pain, swelling, redness, or itching at the injection site.
• Headache
• Fatigue
• Fever
• Nausea
• Diarrhea
• Rash
• Insomnia
• Muscle pain or weakness
• Dizziness

These side effects are typically mild to moderate and tend to improve over time as the body adjusts to the medication. However, if any of these side effects persist or worsen, it’s important to inform your healthcare provider.

In addition to the common side effects listed above, Cabenuva may also cause more serious side effects in some individuals. These can include:

• Allergic reactions: Symptoms may include rash, itching, swelling of the face, lips, or tongue, difficulty breathing, or severe dizziness. Seek immediate medical attention if you experience any signs of an allergic reaction.
• Liver problems: Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, or unexplained fatigue. Contact your healthcare provider if you experience any symptoms of liver problems.
• Changes in mood or behavior: Some people may experience depression, anxiety, or other changes in mood or behavior while taking Cabenuva. It’s important to discuss any concerns with your healthcare provider.
• Worsening of hepatitis B: If you have HIV-1 and hepatitis B virus (HBV) co-infection, discontinuing treatment with Cabenuva may lead to a flare-up of hepatitis B. Your healthcare provider will closely monitor you during treatment.
• Immune reconstitution syndrome: In some individuals with advanced HIV infection, immune reconstitution syndrome may occur after starting antiretroviral therapy, including Cabenuva. This condition involves the rapid recovery of the immune system, leading to inflammatory reactions to previously acquired infections. Notify your healthcare provider if you experience any new or worsening symptoms after starting Cabenuva.

These are not all the possible side effects of Cabenuva. If you experience any other symptoms that are bothersome or concerning, it’s essential to contact your healthcare provider for advice. Always follow your healthcare provider’s instructions for monitoring and managing side effects while taking Cabenuva.

What should I know about storage and disposal of this medication?

Storage and disposal:

Storage:

• Cabenuva injections should be stored in the original packaging at room temperature (between 68°F to 77°F or 20°C to 25°C).
• Keep Cabenuva out of reach of children and pets.
• Protect Cabenuva from light and moisture.
• Do not freeze Cabenuva.
• Do not use Cabenuva if it is discolored or contains particles.

Disposal:

• Dispose of any unused Cabenuva injections properly according to local regulations.
• Do not throw Cabenuva in household trash or flush it down the toilet.
• Ask your healthcare provider or pharmacist about the proper disposal method in your area.

In case of emergency/overdose

• In case of an emergency or overdose, seek immediate medical attention.
• Contact your healthcare provider or local poison control center for guidance on what to do.
• Be prepared to provide information such as the amount of medication taken and any symptoms experienced.

What other information should I know?

• Follow the dosing schedule prescribed by your healthcare provider for Cabenuva.
• Do not miss any scheduled appointments for Cabenuva injections.
• Inform your healthcare provider of any other medications or supplements you are taking, as they may interact with Cabenuva.
• Report any side effects or concerns to your healthcare provider promptly.
• Continue to practice safe sex and take other precautions to prevent the transmission of HIV to others.
• Keep a record of your Cabenuva injections and any side effects experienced.
• Attend regular follow-up appointments with your healthcare provider for monitoring and management of your HIV infection.

It’s crucial to follow your healthcare provider’s instructions carefully and seek help promptly in case of any concerns or emergencies related to Cabenuva.