WARNING

Celebrex (celecoxib) is a medication primarily used to treat pain, inflammation, and stiffness caused by conditions like arthritis. Like all medications, Celebrex carries potential risks and side effects, which include:

• Cardiovascular Risk: Celebrex has been associated with an increased risk of heart attack, stroke, and other cardiovascular problems, especially when used long-term or in high doses.
• Gastrointestinal Issues: It can cause stomach bleeding, ulcers, or perforation of the stomach or intestines, which can be serious and potentially life-threatening.
• Kidney Effects: Celebrex may affect kidney function, particularly in people with pre-existing kidney disease or dehydration.
• Allergic Reactions: Some people may experience allergic reactions such as rash, itching, swelling, dizziness, or trouble breathing.
• Liver Problems: It has been linked to liver damage, although this is rare.
• Interaction with Other Medications: Celebrex can interact with other medications, including certain blood thinners and antidepressants, potentially affecting their effectiveness or increasing the risk of side effects.
• Fluid Retention: It may cause fluid retention, leading to swelling in the legs, ankles, or other parts of the body.
• High Blood Pressure: There is a risk of developing or worsening high blood pressure while taking Celebrex.

It’s important for individuals taking Celebrex to be monitored regularly by their healthcare provider for any signs of these potential risks. The medication should be used at the lowest effective dose for the shortest possible duration to minimize these risks. Always discuss any concerns or questions with a healthcare professional before starting or stopping any medication.

Why is this medication prescribed?

Celebrex (celecoxib) is prescribed primarily for its anti-inflammatory and pain-relieving properties. It is commonly used to treat the following conditions:

• Osteoarthritis: Celebrex helps reduce pain, inflammation, and stiffness associated with osteoarthritis, a degenerative joint disease.
• Rheumatoid Arthritis: It is used to manage the symptoms of rheumatoid arthritis, an autoimmune disorder that causes joint inflammation and pain.
• Ankylosing Spondylitis: Celebrex can relieve symptoms of ankylosing spondylitis, an inflammatory arthritis that primarily affects the spine.
• Acute Pain: It is sometimes prescribed for short-term relief of pain, such as after surgery or due to menstrual cramps.
• Juvenile Rheumatoid Arthritis: In some cases, Celebrex may be used to treat juvenile rheumatoid arthritis in children over the age of 2.

How should this medicine be used?

How Celebrex should be used:

• Dosage: Celebrex is typically taken orally in capsule form. The dosage varies depending on the condition being treated and the severity of symptoms. Your doctor will prescribe the appropriate dosage.
• Administration: It is usually taken once or twice daily with food or milk to help minimize stomach upset.
• Duration: Celebrex should be used at the lowest effective dose for the shortest duration necessary to control symptoms. Long-term use should be under the supervision of a healthcare provider to monitor for potential side effects.
• Special Instructions: Follow your doctor’s instructions carefully. Do not exceed the prescribed dose or take it more frequently than recommended.
• Monitoring: Regular medical check-ups are important to monitor for any signs of adverse effects, especially cardiovascular and gastrointestinal issues.
• Discontinuation: If you need to stop taking Celebrex, your doctor will provide guidance on how to gradually reduce the dosage to minimize withdrawal effects.

It’s crucial to inform your doctor about any other medications you are taking, as well as any medical conditions you have, before starting Celebrex. This helps ensure it is safe and appropriate for you to use.

Other uses for this medicine

In addition to its primary use for arthritis pain, Celebrex may also be prescribed for other conditions, such as:

• • Ankylosing spondylitis: A type of arthritis affecting the spine.

• Menstrual cramps: To relieve pain and discomfort during menstrual periods.
• Acute pain: Such as after surgery or injury, although it is usually used for chronic conditions like arthritis.

What special precautions should I follow?

When taking Celebrex, it’s important to follow specific precautions to minimize risks and ensure safe use:

• Cardiovascular Health: Celebrex may increase the risk of serious cardiovascular events like heart attack or stroke, especially in those with pre-existing cardiovascular conditions. It should be used cautiously in individuals with heart disease or risk factors for heart disease.
• Gastrointestinal Effects: It can cause stomach ulcers, bleeding, or perforation of the stomach or intestines. To reduce this risk, Celebrex is typically prescribed at the lowest effective dose for the shortest duration necessary.
• Kidney Function: Celebrex can affect kidney function, particularly in people with pre-existing kidney disease or those at risk for it. Your doctor may monitor your kidney function regularly if you are on Celebrex.
• Allergic Reactions: Inform your healthcare provider of any allergies you have, as Celebrex can cause allergic reactions such as rash, itching, swelling, dizziness, or trouble breathing.
• Drug Interactions: Celebrex can interact with other medications, including blood thinners, certain antidepressants, and other NSAIDs (non-steroidal anti-inflammatory drugs). Always inform your doctor about all medications you are taking, including over-the-counter drugs and supplements.
• Pregnancy and Breastfeeding: Celebrex should be avoided during the third trimester of pregnancy due to potential risks to the fetus. It may also pass into breast milk, so it’s important to discuss with your doctor if you are breastfeeding.
• Alcohol Use: Limit alcohol consumption while taking Celebrex, as it can increase the risk of stomach bleeding and liver problems.
• Regular Monitoring: Your doctor will likely monitor you regularly while you are taking Celebrex to check for any signs of side effects or complications.

By following these precautions and guidelines, you can help ensure that Celebrex is used safely and effectively for your specific condition. Always consult with your healthcare provider if you have any questions or concerns about its use.

What special dietary instructions should I follow?

There are no specific dietary restrictions for Celebrex, but following a balanced diet can support overall health and help manage any potential gastrointestinal effects. Some general tips include:

• Take Celebrex with food or milk to reduce the risk of stomach upset or irritation.
• Limit alcohol intake, as it can increase the risk of stomach bleeding and liver problems.
• Stay hydrated by drinking enough water, especially if you are prone to kidney issues.

What should I do if I forget a dose?

• Take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule.
• Do not double the dose to catch up. Taking more than the prescribed amount can increase the risk of side effects without providing additional benefit.
• If you are unsure about what to do, consult your doctor or pharmacist for advice.

What side effects can this medication cause?

Celebrex (celecoxib) can cause a range of side effects, which can vary in severity and frequency. Common side effects include:

• Gastrointestinal Effects: The most common side effects are related to the digestive system, such as:
  • Stomach pain
  • Indigestion
  • Heartburn
  • Nausea
  • Diarrhea
  • Gas or bloating
• Cardiovascular Effects: Celebrex can increase the risk of serious cardiovascular events, especially with long-term use or at higher doses. These effects may include:
  • Heart attack
  • Stroke
  • High blood pressure
• Kidney Effects: Celebrex can affect kidney function, particularly in individuals with pre-existing kidney disease or dehydration. Signs of kidney problems may include:
  • Swelling (edema), especially in the legs or ankles
  • Changes in urine output
  • Blood in the urine
• Allergic Reactions: Some people may experience allergic reactions to Celebrex, which can manifest as:
  • Rash
  • Itching
  • Swelling, especially of the face, throat, or tongue
  • Difficulty breathing
• Liver Problems: Celebrex has been associated with liver damage, although this is rare. Symptoms of liver problems may include:
  • Jaundice (yellowing of the skin or eyes)
  • Dark urine
  • Persistent nausea or vomiting
• Other Potential Side Effects: Less common side effects of Celebrex may include:
  • Dizziness
  • Headache
  • Fatigue
  • Insomnia
  • Peripheral edema (swelling of the hands or feet)

It’s important to note that not everyone experiences these side effects, and some individuals may tolerate Celebrex well. However, if you notice any unusual symptoms or side effects while taking Celebrex, it’s crucial to inform your healthcare provider promptly. They can help assess whether the medication is suitable for you or if adjustments are needed in your treatment plan.

What should I know about storage and disposal of this medication?

Storage of Celebrex:

• Room Temperature: Store Celebrex capsules at room temperature between 68-77°F (20-25°C).
• Protection from Light and Moisture: Keep the medication in its original container tightly closed and protect it from light and moisture.
• Keep Out of Reach of Children: Store Celebrex in a secure place where children and pets cannot access it.
• Avoid Bathroom Storage: Do not store Celebrex in the bathroom, as moisture and humidity can affect the medication.
• Check Expiry Date: Do not use Celebrex if it has expired. Dispose of expired medication properly.

Disposal of Celebrex:

• Unused Medication: If you have unused or expired Celebrex, do not flush it down the toilet or pour it down the drain unless specifically instructed to do so.
• Drug Take-Back Programs: Use authorized drug take-back programs or community disposal programs to safely dispose of unused medications. These programs help prevent environmental contamination and misuse.
• FDA Guidelines: Follow FDA guidelines on safe disposal of medications. If no take-back programs are available, mix Celebrex with an unappealing substance (like dirt, cat litter) in a sealed plastic bag before disposing of it in the trash.

In case of emergency/overdose

• Seek Immediate Medical Attention: If you suspect an overdose of Celebrex (celecoxib), seek emergency medical assistance or call the Poison Help line at 1-800-222-1222 in the United States.
• Symptoms of Overdose: Symptoms of Celebrex overdose may include drowsiness, nausea, vomiting, stomach pain, shallow breathing, fainting, or coma.
• Do Not Delay Treatment: Do not wait for symptoms to worsen before seeking help. Prompt medical attention is essential to manage overdose effectively.

What other information should I know?

• Regular Monitoring: Your doctor will likely monitor you regularly while taking Celebrex to check for any signs of side effects, especially cardiovascular and gastrointestinal issues.
• Avoid Alcohol: Limit alcohol consumption while taking Celebrex, as it can increase the risk of stomach bleeding and liver problems.
• Drug Interactions: Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, as Celebrex can interact with certain medications.
• Pregnancy and Breastfeeding: Celebrex should be avoided during the third trimester of pregnancy due to potential risks to the fetus. Consult with your doctor if you are pregnant or breastfeeding.
• Medical Conditions: Inform your doctor about any medical conditions you have, especially heart disease, kidney problems, or gastrointestinal disorders, before starting Celebrex.

By following these guidelines for storage, disposal, emergency management, and other important considerations, you can ensure safe and effective use of Celebrex under the supervision of your healthcare provider.